Human Gene CDCA7 (ENST00000306721.8_9) from GENCODE V47lift37
  Description: cell division cycle associated 7, transcript variant 1 (from RefSeq NM_031942.5)
Gencode Transcript: ENST00000306721.8_9
Gencode Gene: ENSG00000144354.15_15
Transcript (Including UTRs)
   Position: hg19 chr2:174,219,600-174,233,725 Size: 14,126 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr2:174,219,692-174,232,392 Size: 12,701 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:174,219,600-174,233,725)mRNA (may differ from genome)Protein (450 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDCA7_HUMAN
DESCRIPTION: RecName: Full=Cell division cycle-associated protein 7; AltName: Full=Protein JPO1;
FUNCTION: Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis.
INDUCTION: Activated by MYC and possibly E2F1.
MISCELLANEOUS: CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines.
SEQUENCE CAUTION: Sequence=CAH56357.1; Type=Frameshift; Positions=260;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CDCA7
Diseases sorted by gene-association score: immunodeficiency-centromeric instability-facial anomalies syndrome 3* (1231), immunodeficiency-centromeric instability-facial anomalies syndrome* (230)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.13 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 110.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.0092-0.293 Picture PostScript Text
3' UTR -284.501333-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018866 - Znf-4CXXC_R1

Pfam Domains:
PF10497 - Zinc-finger domain of monoamine-oxidase A repressor R1

ModBase Predicted Comparative 3D Structure on Q9BWT1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0042127 regulation of cell proliferation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AY029179 - Homo sapiens c-Myc target JPO1 (JPO1) mRNA, complete cds.
AK027642 - Homo sapiens cDNA FLJ14736 fis, clone NT2RP3002181.
AK027628 - Homo sapiens cDNA FLJ14722 fis, clone NT2RP3001621.
BC027966 - Homo sapiens cell division cycle associated 7, mRNA (cDNA clone MGC:34109 IMAGE:5227112), complete cds.
AK300949 - Homo sapiens cDNA FLJ54758 complete cds, highly similar to Homo sapiens cell division cycle associated 7 (CDCA7), transcript variant 1, mRNA.
AK297097 - Homo sapiens cDNA FLJ55101 complete cds, highly similar to Homo sapiens cell division cycle associated 7 (CDCA7), transcript variant 2, mRNA.
AK075134 - Homo sapiens cDNA FLJ90653 fis, clone PLACE1004519.
AK297245 - Homo sapiens cDNA FLJ52932 complete cds, highly similar to Homo sapiens cell division cycle associated 7 (CDCA7), transcript variant 2, mRNA.
AK223524 - Homo sapiens mRNA for cell division cycle associated protein 7 isoform 2 variant, clone: FCC123E09.
AL834186 - Homo sapiens mRNA; cDNA DKFZp667L165 (from clone DKFZp667L165).
JD310529 - Sequence 291553 from Patent EP1572962.
CU693352 - Synthetic construct Homo sapiens gateway clone IMAGE:100019116 5' read CDCA7 mRNA.
HQ447803 - Synthetic construct Homo sapiens clone IMAGE:100071146; CCSB008287_02 cell division cycle associated 7 (CDCA7) gene, encodes complete protein.
KJ894909 - Synthetic construct Homo sapiens clone ccsbBroadEn_04303 CDCA7 gene, encodes complete protein.
AB527763 - Synthetic construct DNA, clone: pF1KB5801, Homo sapiens CDCA7 gene for cell division cycle associated 7, without stop codon, in Flexi system.
AL833728 - Homo sapiens mRNA; cDNA DKFZp666F035 (from clone DKFZp666F035).
BC015124 - Homo sapiens, clone IMAGE:3829029, mRNA, partial cds.
JD186137 - Sequence 167161 from Patent EP1572962.
JD460402 - Sequence 441426 from Patent EP1572962.
JD110399 - Sequence 91423 from Patent EP1572962.
JD418056 - Sequence 399080 from Patent EP1572962.
JD230926 - Sequence 211950 from Patent EP1572962.
JD235401 - Sequence 216425 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DLP8, B4DV66, CDCA7_HUMAN, ENST00000306721.1, ENST00000306721.2, ENST00000306721.3, ENST00000306721.4, ENST00000306721.5, ENST00000306721.6, ENST00000306721.7, JPO1, NM_031942, Q53EW5, Q580W9, Q658K4, Q658N4, Q8NBY9, Q96BV8, Q96SP5, Q9BWT1, uc317nxh.1, uc317nxh.2
UCSC ID: ENST00000306721.8_9
RefSeq Accession: NM_031942.5
Protein: Q9BWT1 (aka CDCA7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.