Human Gene CDK15 (ENST00000652192.3_7) from GENCODE V47lift37
  Description: cyclin dependent kinase 15, transcript variant 4 (from RefSeq NM_001366386.2)
Gencode Transcript: ENST00000652192.3_7
Gencode Gene: ENSG00000138395.17_11
Transcript (Including UTRs)
   Position: hg19 chr2:202,671,260-202,760,273 Size: 89,014 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr2:202,671,388-202,755,617 Size: 84,230 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:202,671,260-202,760,273)mRNA (may differ from genome)Protein (435 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDK15_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase 15; EC=2.7.11.22; AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein; AltName: Full=Cell division protein kinase 15; AltName: Full=Serine/threonine-protein kinase ALS2CR7; AltName: Full=Serine/threonine-protein kinase PFTAIRE-2;
FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=BAD18656.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.90128-0.320 Picture PostScript Text
3' UTR -571.602283-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q96Q40
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030332 cyclin binding
GO:0046872 metal ion binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK292434 - Homo sapiens cDNA FLJ77382 complete cds, highly similar to Homo sapiens amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 (ALS2CR7), mRNA.
AK310050 - Homo sapiens cDNA, FLJ17092.
AB053308 - Homo sapiens ALS2CR7 mRNA, complete cds.
AX772791 - Sequence 1 from Patent WO03046167.
AK131512 - Homo sapiens cDNA FLJ16732 fis, clone BNGH42005017, moderately similar to SERINE/THREONINE-PROTEIN KINASE PCTAIRE-1 (EC 2.7.1.-).
BX647394 - Homo sapiens mRNA; cDNA DKFZp686K20144 (from clone DKFZp686K20144).
BC038807 - Homo sapiens PFTAIRE protein kinase 2, mRNA (cDNA clone MGC:46456 IMAGE:5200755), complete cds.
EU831828 - Synthetic construct Homo sapiens clone HAIB:100066857; DKFZo004A0522 PFTAIRE protein kinase 2 protein (PFTK2) gene, encodes complete protein.
EU831752 - Synthetic construct Homo sapiens clone HAIB:100066781; DKFZo008A0521 PFTAIRE protein kinase 2 protein (PFTK2) gene, encodes complete protein.
EU831827 - Synthetic construct Homo sapiens clone HAIB:100066856; DKFZo004A0422 PFTAIRE protein kinase 2 protein (PFTK2) gene, encodes complete protein.
EU831751 - Synthetic construct Homo sapiens clone HAIB:100066780; DKFZo008A0421 PFTAIRE protein kinase 2 protein (PFTK2) gene, encodes complete protein.
KJ903116 - Synthetic construct Homo sapiens clone ccsbBroadEn_12510 CDK15 gene, encodes complete protein.
KJ905528 - Synthetic construct Homo sapiens clone ccsbBroadEn_15139 CDK15 gene, encodes complete protein.
AK091710 - Homo sapiens cDNA FLJ34391 fis, clone HCHON2000199.
JD358664 - Sequence 339688 from Patent EP1572962.
JD298546 - Sequence 279570 from Patent EP1572962.
JD142750 - Sequence 123774 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8R9, ALS2CR7, B8ZZX0, C9J1N8, C9K003, CDK15_HUMAN, ENST00000652192.1, ENST00000652192.2, F8W6H8, NM_001366386, PFTK2, Q4ZG86, Q53TV1, Q6ZMR9, Q8IUP1, Q96Q40, uc328tzk.1, uc328tzk.2
UCSC ID: ENST00000652192.3_7
RefSeq Accession: NM_001366386.2
Protein: Q96Q40 (aka CDK15_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.