Human Gene CDK19 (ENST00000368911.8_7) from GENCODE V47lift37
  Description: cyclin dependent kinase 19, transcript variant 1 (from RefSeq NM_015076.5)
Gencode Transcript: ENST00000368911.8_7
Gencode Gene: ENSG00000155111.15_14
Transcript (Including UTRs)
   Position: hg19 chr6:110,931,181-111,136,672 Size: 205,492 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr6:110,935,738-111,136,339 Size: 200,602 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:110,931,181-111,136,672)mRNA (may differ from genome)Protein (502 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDK19_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase 19; EC=2.7.11.22; AltName: Full=CDC2-related protein kinase 6; AltName: Full=Cell division cycle 2-like protein kinase 6; AltName: Full=Cell division protein kinase 19; AltName: Full=Cyclin-dependent kinase 11; AltName: Full=Death-preventing kinase;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=AAH24247.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.57 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 254.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -156.60333-0.470 Picture PostScript Text
3' UTR -1192.604557-0.262 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9BWU1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007346 regulation of mitotic cell cycle
GO:0016310 phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0050729 positive regulation of inflammatory response
GO:0071222 cellular response to lipopolysaccharide

Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016592 mediator complex


-  Descriptions from all associated GenBank mRNAs
  AB028951 - Homo sapiens mRNA for KIAA1028 protein, partial cds.
LF384628 - JP 2014500723-A/192131: Polycomb-Associated Non-Coding RNAs.
BC037289 - Homo sapiens cell division cycle 2-like 6 (CDK8-like), mRNA (cDNA clone MGC:33263 IMAGE:5266531), complete cds.
AY028424 - Homo sapiens death-preventing kinase mRNA, complete cds.
BC024247 - Homo sapiens cell division cycle 2-like 6 (CDK8-like), mRNA (cDNA clone IMAGE:4823354), partial cds.
AK292360 - Homo sapiens cDNA FLJ76437 complete cds, highly similar to Homo sapiens cell division cycle 2-like 6 (CDK8-like) (CDC2L6), mRNA.
JX028238 - Homo sapiens cell-line HeLa cyclin dependent kinase 19 variant 2 (CDK19) mRNA, complete cds, alternatively spliced.
AB384086 - Synthetic construct DNA, clone: pF1KSDA1028, Homo sapiens CDC2L6 gene for cell division cycle 2-like protein kinase 6, complete cds, without stop codon, in Flexi system.
MA620205 - JP 2018138019-A/192131: Polycomb-Associated Non-Coding RNAs.
AL122055 - Homo sapiens mRNA; cDNA DKFZp434M058 (from clone DKFZp434M058).
JD348474 - Sequence 329498 from Patent EP1572962.
JD372756 - Sequence 353780 from Patent EP1572962.
JD174765 - Sequence 155789 from Patent EP1572962.
JD488937 - Sequence 469961 from Patent EP1572962.
JD288165 - Sequence 269189 from Patent EP1572962.
JD174394 - Sequence 155418 from Patent EP1572962.
JD427638 - Sequence 408662 from Patent EP1572962.
JD080662 - Sequence 61686 from Patent EP1572962.
JD146992 - Sequence 128016 from Patent EP1572962.
JD530405 - Sequence 511429 from Patent EP1572962.
JD147142 - Sequence 128166 from Patent EP1572962.
JD285899 - Sequence 266923 from Patent EP1572962.
JD539061 - Sequence 520085 from Patent EP1572962.
JD083008 - Sequence 64032 from Patent EP1572962.
JD315802 - Sequence 296826 from Patent EP1572962.
JD267769 - Sequence 248793 from Patent EP1572962.
JD166029 - Sequence 147053 from Patent EP1572962.
JD263371 - Sequence 244395 from Patent EP1572962.
JD512113 - Sequence 493137 from Patent EP1572962.
JD298643 - Sequence 279667 from Patent EP1572962.
JD202185 - Sequence 183209 from Patent EP1572962.
JD509678 - Sequence 490702 from Patent EP1572962.
JD476936 - Sequence 457960 from Patent EP1572962.
JD256632 - Sequence 237656 from Patent EP1572962.
JD219120 - Sequence 200144 from Patent EP1572962.
JD064590 - Sequence 45614 from Patent EP1572962.
JD242875 - Sequence 223899 from Patent EP1572962.
JD333284 - Sequence 314308 from Patent EP1572962.
JD072084 - Sequence 53108 from Patent EP1572962.
JD240410 - Sequence 221434 from Patent EP1572962.
JD397824 - Sequence 378848 from Patent EP1572962.
JD095258 - Sequence 76282 from Patent EP1572962.
JD212861 - Sequence 193885 from Patent EP1572962.
JD542848 - Sequence 523872 from Patent EP1572962.
JD560912 - Sequence 541936 from Patent EP1572962.
JD262033 - Sequence 243057 from Patent EP1572962.
JD160720 - Sequence 141744 from Patent EP1572962.
JD152934 - Sequence 133958 from Patent EP1572962.
JD198300 - Sequence 179324 from Patent EP1572962.
JD271993 - Sequence 253017 from Patent EP1572962.
JD152935 - Sequence 133959 from Patent EP1572962.
JD325840 - Sequence 306864 from Patent EP1572962.
JD367185 - Sequence 348209 from Patent EP1572962.
JD140581 - Sequence 121605 from Patent EP1572962.
JD198301 - Sequence 179325 from Patent EP1572962.
JD160719 - Sequence 141743 from Patent EP1572962.
JD152933 - Sequence 133957 from Patent EP1572962.
JD266155 - Sequence 247179 from Patent EP1572962.
JD543653 - Sequence 524677 from Patent EP1572962.
JD426878 - Sequence 407902 from Patent EP1572962.
JD137172 - Sequence 118196 from Patent EP1572962.
JD379221 - Sequence 360245 from Patent EP1572962.
JD280718 - Sequence 261742 from Patent EP1572962.
JD521797 - Sequence 502821 from Patent EP1572962.
JD375688 - Sequence 356712 from Patent EP1572962.
JD286103 - Sequence 267127 from Patent EP1572962.
JD268397 - Sequence 249421 from Patent EP1572962.
JD267712 - Sequence 248736 from Patent EP1572962.
JD424224 - Sequence 405248 from Patent EP1572962.
JD400204 - Sequence 381228 from Patent EP1572962.
JD487263 - Sequence 468287 from Patent EP1572962.
JD282123 - Sequence 263147 from Patent EP1572962.
JD509901 - Sequence 490925 from Patent EP1572962.
JD305772 - Sequence 286796 from Patent EP1572962.
JD044555 - Sequence 25579 from Patent EP1572962.
JD412079 - Sequence 393103 from Patent EP1572962.
JD095695 - Sequence 76719 from Patent EP1572962.
JD435621 - Sequence 416645 from Patent EP1572962.
JD266993 - Sequence 248017 from Patent EP1572962.
JD245118 - Sequence 226142 from Patent EP1572962.
JD378504 - Sequence 359528 from Patent EP1572962.
JD313140 - Sequence 294164 from Patent EP1572962.
JD067957 - Sequence 48981 from Patent EP1572962.
JD067956 - Sequence 48980 from Patent EP1572962.
JD310607 - Sequence 291631 from Patent EP1572962.
AK300567 - Homo sapiens cDNA FLJ50029 complete cds, highly similar to Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22).
JD120186 - Sequence 101210 from Patent EP1572962.
JD118838 - Sequence 99862 from Patent EP1572962.
JD099243 - Sequence 80267 from Patent EP1572962.
JD560886 - Sequence 541910 from Patent EP1572962.
JD097936 - Sequence 78960 from Patent EP1572962.
JD206893 - Sequence 187917 from Patent EP1572962.
JD187489 - Sequence 168513 from Patent EP1572962.
JD309685 - Sequence 290709 from Patent EP1572962.
JD239389 - Sequence 220413 from Patent EP1572962.
JD118158 - Sequence 99182 from Patent EP1572962.
JD292684 - Sequence 273708 from Patent EP1572962.
JD364183 - Sequence 345207 from Patent EP1572962.
JD123222 - Sequence 104246 from Patent EP1572962.
JD516261 - Sequence 497285 from Patent EP1572962.
JD148843 - Sequence 129867 from Patent EP1572962.
JD370467 - Sequence 351491 from Patent EP1572962.
JD187156 - Sequence 168180 from Patent EP1572962.
LF322269 - JP 2014500723-A/129772: Polycomb-Associated Non-Coding RNAs.
LF322266 - JP 2014500723-A/129769: Polycomb-Associated Non-Coding RNAs.
MA557846 - JP 2018138019-A/129772: Polycomb-Associated Non-Coding RNAs.
MA557843 - JP 2018138019-A/129769: Polycomb-Associated Non-Coding RNAs.
LF322249 - JP 2014500723-A/129752: Polycomb-Associated Non-Coding RNAs.
AJ420571 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1628928.
JD436447 - Sequence 417471 from Patent EP1572962.
JD468610 - Sequence 449634 from Patent EP1572962.
JD445050 - Sequence 426074 from Patent EP1572962.
JD471169 - Sequence 452193 from Patent EP1572962.
JD178362 - Sequence 159386 from Patent EP1572962.
JD222586 - Sequence 203610 from Patent EP1572962.
JD340088 - Sequence 321112 from Patent EP1572962.
JD471421 - Sequence 452445 from Patent EP1572962.
JD496663 - Sequence 477687 from Patent EP1572962.
JD540786 - Sequence 521810 from Patent EP1572962.
MA557826 - JP 2018138019-A/129752: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BWU1 (Reactome details) participates in the following event(s):

R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: CDC2L6, CDK11, CDK19_HUMAN, ENST00000368911.1, ENST00000368911.2, ENST00000368911.3, ENST00000368911.4, ENST00000368911.5, ENST00000368911.6, ENST00000368911.7, KIAA1028, NM_015076, Q5JQZ7, Q5JR00, Q8TC78, Q9BWU1, Q9UPX2, uc318heh.1, uc318heh.2
UCSC ID: ENST00000368911.8_7
RefSeq Accession: NM_015076.5
Protein: Q9BWU1 (aka CDK19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.