ID:CDO1_HUMAN DESCRIPTION: RecName: Full=Cysteine dioxygenase type 1; EC=1.13.11.20; AltName: Full=Cysteine dioxygenase type I; Short=CDO; Short=CDO-I; FUNCTION: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. CATALYTIC ACTIVITY: L-cysteine + O(2) = 3-sulfinoalanine. COFACTOR: Binds 1 iron ion per subunit. Zinc to a much lesser extent. PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. SUBUNIT: Monomer. TISSUE SPECIFICITY: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells. INDUCTION: In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA). PTM: The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. SIMILARITY: Belongs to the cysteine dioxygenase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16878
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005506 iron ion binding GO:0008198 ferrous iron binding GO:0016491 oxidoreductase activity GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0017172 cysteine dioxygenase activity GO:0046872 metal ion binding GO:0051213 dioxygenase activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
