ID:CDS1_HUMAN DESCRIPTION: RecName: Full=Phosphatidate cytidylyltransferase 1; EC=2.7.7.41; AltName: Full=CDP-DAG synthase 1; AltName: Full=CDP-DG synthase 1; AltName: Full=CDP-diacylglycerol synthase 1; Short=CDS 1; AltName: Full=CDP-diglyceride pyrophosphorylase 1; AltName: Full=CDP-diglyceride synthase 1; AltName: Full=CTP:phosphatidate cytidylyltransferase 1; FUNCTION: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells. CATALYTIC ACTIVITY: CTP + phosphatidate = diphosphate + CDP- diacylglycerol. COFACTOR: Magnesium (By similarity). PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Cytoplasmic aspect of the endoplasmic reticulum (By similarity). TISSUE SPECIFICITY: Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver. SIMILARITY: Belongs to the CDS family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01148 - Cytidylyltransferase family
ModBase Predicted Comparative 3D Structure on Q92903
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006655 phosphatidylglycerol biosynthetic process GO:0006657 CDP-choline pathway GO:0006661 phosphatidylinositol biosynthetic process GO:0007165 signal transduction GO:0007602 phototransduction GO:0008654 phospholipid biosynthetic process GO:0016024 CDP-diacylglycerol biosynthetic process
BioCarta from NCI Cancer Genome Anatomy Project h_atrbrcaPathway - Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility h_g2Pathway - Cell Cycle: G2/M Checkpoint h_atmPathway - ATM Signaling Pathway h_plk3Pathway - Regulation of cell cycle progression by Plk3
Reactome (by CSHL, EBI, and GO)
Protein Q92903 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
