ID:CDX2_HUMAN DESCRIPTION: RecName: Full=Homeobox protein CDX-2; AltName: Full=CDX-3; AltName: Full=Caudal-type homeobox protein 2; FUNCTION: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylation of Ser-60 mediates the transactivation capacity (By similarity). SIMILARITY: Belongs to the Caudal homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDX2ID326.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99626
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0008327 methyl-CpG binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001568 blood vessel development GO:0001824 blastocyst development GO:0001829 trophectodermal cell differentiation GO:0001890 placenta development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0008284 positive regulation of cell proliferation GO:0008333 endosome to lysosome transport GO:0009887 animal organ morphogenesis GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0014807 regulation of somitogenesis GO:0030154 cell differentiation GO:0035019 somatic stem cell population maintenance GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity GO:0045597 positive regulation of cell differentiation GO:0045893 positive regulation of transcription, DNA-templated GO:0060575 intestinal epithelial cell differentiation GO:0060711 labyrinthine layer development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
