Human Gene CEBPD (ENST00000408965.4_6) from GENCODE V47lift37
  Description: CCAAT enhancer binding protein delta (from RefSeq NM_005195.4)
Gencode Transcript: ENST00000408965.4_6
Gencode Gene: ENSG00000221869.5_8
Transcript (Including UTRs)
   Position: hg19 chr8:48,649,475-48,650,726 Size: 1,252 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr8:48,649,873-48,650,682 Size: 810 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:48,649,475-48,650,726)mRNA (may differ from genome)Protein (269 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CEBPD_HUMAN
DESCRIPTION: RecName: Full=CCAAT/enhancer-binding protein delta; Short=C/EBP delta; AltName: Full=Nuclear factor NF-IL6-beta; Short=NF-IL6-beta;
FUNCTION: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.
SUBUNIT: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1. Interacts with PRDM16 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the bZIP family. C/EBP subfamily.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CEBPD
Diseases sorted by gene-association score: leukoencephalopathy with vanishing white matter (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 202.93 RPKM in Ovary
Total median expression: 3489.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.8044-0.291 Picture PostScript Text
3' UTR -102.90398-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR016468 - CCAAT/enhancer-binding

Pfam Domains:
PF07716 - Basic region leucine zipper

SCOP Domains:
90257 - Myosin rod fragments
57959 - Leucine zipper domain
144284 - Sec2 N-terminal region

ModBase Predicted Comparative 3D Structure on P49716
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0019221 cytokine-mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  M83667 - Human NF-IL6-beta protein mRNA, complete cds.
BC023510 - Homo sapiens cDNA clone IMAGE:3959384, **** WARNING: chimeric clone ****.
BC094715 - Homo sapiens CCAAT/enhancer binding protein (C/EBP), delta, mRNA (cDNA clone IMAGE:30332178), complete cds.
JD346090 - Sequence 327114 from Patent EP1572962.
E05171 - cDNA sequence coding for IL-6 production stimulating nucleic factor (NF-IL6 beta).
JD244986 - Sequence 226010 from Patent EP1572962.
JD336569 - Sequence 317593 from Patent EP1572962.
JD394690 - Sequence 375714 from Patent EP1572962.
JD021587 - Sequence 2611 from Patent EP1572962.
JD142288 - Sequence 123312 from Patent EP1572962.
JD324346 - Sequence 305370 from Patent EP1572962.
JD441856 - Sequence 422880 from Patent EP1572962.
BC105109 - Homo sapiens CCAAT/enhancer binding protein (C/EBP), delta, mRNA (cDNA clone MGC:132769 IMAGE:8144112), complete cds.
JD031592 - Sequence 12616 from Patent EP1572962.
JD023254 - Sequence 4278 from Patent EP1572962.
JD029835 - Sequence 10859 from Patent EP1572962.
EU831483 - Synthetic construct Homo sapiens clone HAIB:100066512; DKFZo008H0117 CCAAT/enhancer binding protein (C/EBP), delta protein (CEBPD) gene, encodes complete protein.
EU831570 - Synthetic construct Homo sapiens clone HAIB:100066599; DKFZo004H0118 CCAAT/enhancer binding protein (C/EBP), delta protein (CEBPD) gene, encodes complete protein.
JD023967 - Sequence 4991 from Patent EP1572962.
JD033888 - Sequence 14912 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P49716 (Reactome details) participates in the following event(s):

R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-1266738 Developmental Biology
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CEBPD_HUMAN, ENST00000408965.1, ENST00000408965.2, ENST00000408965.3, NM_005195, P49716, Q14937, Q2M2X9, uc319fdf.1, uc319fdf.2
UCSC ID: ENST00000408965.4_6
RefSeq Accession: NM_005195.4
Protein: P49716 (aka CEBPD_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.