ID:CEBPE_HUMAN DESCRIPTION: RecName: Full=CCAAT/enhancer-binding protein epsilon; Short=C/EBP epsilon; FUNCTION: C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. SUBUNIT: Binds DNA as a dimer and can form stable heterodimers with C/EBP delta. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines. PTM: Phosphorylated. SIMILARITY: Belongs to the bZIP family. C/EBP subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SEQUENCE CAUTION: Sequence=AAC51130.1; Type=Frameshift; Positions=4; WEB RESOURCE: Name=CEBPEbase; Note=CEBPE mutation db; URL="http://bioinf.uta.fi/CEBPEbase/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15744
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006909 phagocytosis GO:0006952 defense response GO:0010628 positive regulation of gene expression GO:0030099 myeloid cell differentiation GO:0030225 macrophage differentiation GO:0030851 granulocyte differentiation GO:0042089 cytokine biosynthetic process GO:0042742 defense response to bacterium GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0071222 cellular response to lipopolysaccharide
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
