Human Gene CEBPZ (ENST00000234170.10_7) from GENCODE V47lift37
  Description: CCAAT enhancer binding protein zeta (from RefSeq NM_005760.3)
Gencode Transcript: ENST00000234170.10_7
Gencode Gene: ENSG00000115816.15_12
Transcript (Including UTRs)
   Position: hg19 chr2:37,428,755-37,458,739 Size: 29,985 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr2:37,428,907-37,458,710 Size: 29,804 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:37,428,755-37,458,739)mRNA (may differ from genome)Protein (1054 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CEBPZ_HUMAN
DESCRIPTION: RecName: Full=CCAAT/enhancer-binding protein zeta; AltName: Full=CCAAT-box-binding transcription factor; Short=CBF; Short=CCAAT-binding factor;
FUNCTION: Stimulates transcription from the HSP70 promoter.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the CBF/MAK21 family.
SEQUENCE CAUTION: Sequence=AAA51924.1; Type=Frameshift; Positions=998;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.64 RPKM in Testis
Total median expression: 614.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.4029-0.186 Picture PostScript Text
3' UTR -16.00152-0.105 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR005612 - CCAAT-binding_factor

Pfam Domains:
PF03914 - CBF/Mak21 family

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q03701
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003723 RNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF210928 - JP 2014500723-A/18431: Polycomb-Associated Non-Coding RNAs.
LF210930 - JP 2014500723-A/18433: Polycomb-Associated Non-Coding RNAs.
BC034475 - Homo sapiens CCAAT/enhancer binding protein (C/EBP), zeta, mRNA (cDNA clone MGC:26288 IMAGE:4822708), complete cds.
LF342160 - JP 2014500723-A/149663: Polycomb-Associated Non-Coding RNAs.
M37197 - Human CCAAT-box-binding factor (CBF) mRNA, complete cds.
LF342161 - JP 2014500723-A/149664: Polycomb-Associated Non-Coding RNAs.
JD060560 - Sequence 41584 from Patent EP1572962.
LF342163 - JP 2014500723-A/149666: Polycomb-Associated Non-Coding RNAs.
AK312322 - Homo sapiens cDNA, FLJ92633, highly similar to Homo sapiens CCAAT-box-binding transcription factor (CBF2), mRNA.
LF342164 - JP 2014500723-A/149667: Polycomb-Associated Non-Coding RNAs.
LF342165 - JP 2014500723-A/149668: Polycomb-Associated Non-Coding RNAs.
LF342166 - JP 2014500723-A/149669: Polycomb-Associated Non-Coding RNAs.
LF342167 - JP 2014500723-A/149670: Polycomb-Associated Non-Coding RNAs.
LF342169 - JP 2014500723-A/149672: Polycomb-Associated Non-Coding RNAs.
LF342170 - JP 2014500723-A/149673: Polycomb-Associated Non-Coding RNAs.
LF342171 - JP 2014500723-A/149674: Polycomb-Associated Non-Coding RNAs.
LF342173 - JP 2014500723-A/149676: Polycomb-Associated Non-Coding RNAs.
LF342175 - JP 2014500723-A/149678: Polycomb-Associated Non-Coding RNAs.
LF342177 - JP 2014500723-A/149680: Polycomb-Associated Non-Coding RNAs.
LF342178 - JP 2014500723-A/149681: Polycomb-Associated Non-Coding RNAs.
LF342180 - JP 2014500723-A/149683: Polycomb-Associated Non-Coding RNAs.
LF342181 - JP 2014500723-A/149684: Polycomb-Associated Non-Coding RNAs.
LF342182 - JP 2014500723-A/149685: Polycomb-Associated Non-Coding RNAs.
MA577737 - JP 2018138019-A/149663: Polycomb-Associated Non-Coding RNAs.
MA577738 - JP 2018138019-A/149664: Polycomb-Associated Non-Coding RNAs.
MA577740 - JP 2018138019-A/149666: Polycomb-Associated Non-Coding RNAs.
MA577741 - JP 2018138019-A/149667: Polycomb-Associated Non-Coding RNAs.
MA577742 - JP 2018138019-A/149668: Polycomb-Associated Non-Coding RNAs.
MA577743 - JP 2018138019-A/149669: Polycomb-Associated Non-Coding RNAs.
MA577744 - JP 2018138019-A/149670: Polycomb-Associated Non-Coding RNAs.
MA577746 - JP 2018138019-A/149672: Polycomb-Associated Non-Coding RNAs.
MA577747 - JP 2018138019-A/149673: Polycomb-Associated Non-Coding RNAs.
MA577748 - JP 2018138019-A/149674: Polycomb-Associated Non-Coding RNAs.
MA577750 - JP 2018138019-A/149676: Polycomb-Associated Non-Coding RNAs.
MA577752 - JP 2018138019-A/149678: Polycomb-Associated Non-Coding RNAs.
MA577754 - JP 2018138019-A/149680: Polycomb-Associated Non-Coding RNAs.
MA577755 - JP 2018138019-A/149681: Polycomb-Associated Non-Coding RNAs.
MA577757 - JP 2018138019-A/149683: Polycomb-Associated Non-Coding RNAs.
MA577758 - JP 2018138019-A/149684: Polycomb-Associated Non-Coding RNAs.
MA577759 - JP 2018138019-A/149685: Polycomb-Associated Non-Coding RNAs.
MA446505 - JP 2018138019-A/18431: Polycomb-Associated Non-Coding RNAs.
MA446507 - JP 2018138019-A/18433: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CBF2, CEBPZ_HUMAN, ENST00000234170.1, ENST00000234170.2, ENST00000234170.3, ENST00000234170.4, ENST00000234170.5, ENST00000234170.6, ENST00000234170.7, ENST00000234170.8, ENST00000234170.9, NM_005760, Q03701, Q8NE75, uc317dyr.1, uc317dyr.2
UCSC ID: ENST00000234170.10_7
RefSeq Accession: NM_005760.3
Protein: Q03701 (aka CEBPZ_HUMAN or CBF_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.