Human Gene CEP170B (ENST00000414716.8_6) from GENCODE V47lift37
  Description: centrosomal protein 170B, transcript variant 1 (from RefSeq NM_001112726.3)
Gencode Transcript: ENST00000414716.8_6
Gencode Gene: ENSG00000099814.17_10
Transcript (Including UTRs)
   Position: hg19 chr14:105,331,605-105,363,084 Size: 31,480 Total Exon Count: 19 Strand: +
Coding Region
   Position: hg19 chr14:105,334,788-105,361,295 Size: 26,508 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:105,331,605-105,363,084)mRNA (may differ from genome)Protein (1554 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K0284_HUMAN
DESCRIPTION: RecName: Full=Protein KIAA0284;
FUNCTION: Plays a role in microtubule organization (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
SIMILARITY: Belongs to the CEP170 family.
SIMILARITY: Contains 1 FHA domain.
SEQUENCE CAUTION: Sequence=AAH47913.1; Type=Frameshift; Positions=1379; Sequence=BAA22953.3; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 39.22 RPKM in Brain - Cerebellum
Total median expression: 738.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.40273-0.544 Picture PostScript Text
3' UTR -795.801789-0.445 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000253 - FHA_dom
IPR008984 - SMAD_FHA_domain

Pfam Domains:
PF00498 - FHA domain
PF15308 - CEP170 C-terminus
PF16697 - Inner membrane component of T3SS, cytoplasmic domain

SCOP Domains:
49879 - SMAD/FHA domain

ModBase Predicted Comparative 3D Structure on Q9Y4F5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  BC172394 - Synthetic construct Homo sapiens clone IMAGE:100069088, MGC:199099 inverted formin, FH2 and WH2 domain containing (INF2) mRNA, encodes complete protein.
AB006622 - Homo sapiens KIAA0284 mRNA for KIAA0284 protein.
AM422012 - Homo sapiens partial mRNA for MLL-KIAA0284 fusion protein (MLL-KIAA0284 gene).
JD215302 - Sequence 196326 from Patent EP1572962.
AB384454 - Synthetic construct DNA, clone: pF1KA0284, Homo sapiens KIAA0284 gene for KIAA0284 protein, complete cds, without stop codon, in Flexi system.
AK091980 - Homo sapiens cDNA FLJ34661 fis, clone KIDNE2018989, weakly similar to Homo sapiens centrosomal protein 170 kDa (CEP170), transcript variant alpha, mRNA.
AX747288 - Sequence 813 from Patent EP1308459.
AK300834 - Homo sapiens cDNA FLJ54165 complete cds.
BC047913 - Homo sapiens KIAA0284, mRNA (cDNA clone IMAGE:6187045), complete cds.
AK025023 - Homo sapiens cDNA: FLJ21370 fis, clone COL03092.
CU690534 - Synthetic construct Homo sapiens gateway clone IMAGE:100021235 5' read KIAA0284 mRNA.
KJ904109 - Synthetic construct Homo sapiens clone ccsbBroadEn_13503 KIAA0284 gene, encodes complete protein.
JD066334 - Sequence 47358 from Patent EP1572962.
JD500424 - Sequence 481448 from Patent EP1572962.
JD134443 - Sequence 115467 from Patent EP1572962.
JD386924 - Sequence 367948 from Patent EP1572962.
JD458194 - Sequence 439218 from Patent EP1572962.
JD051051 - Sequence 32075 from Patent EP1572962.
JD365836 - Sequence 346860 from Patent EP1572962.
JD055043 - Sequence 36067 from Patent EP1572962.
JD133705 - Sequence 114729 from Patent EP1572962.
JD123298 - Sequence 104322 from Patent EP1572962.
JD390283 - Sequence 371307 from Patent EP1572962.
JD338154 - Sequence 319178 from Patent EP1572962.
JD222012 - Sequence 203036 from Patent EP1572962.
JD389436 - Sequence 370460 from Patent EP1572962.
JD417012 - Sequence 398036 from Patent EP1572962.
JD538126 - Sequence 519150 from Patent EP1572962.
JD219525 - Sequence 200549 from Patent EP1572962.
JD341565 - Sequence 322589 from Patent EP1572962.
JD452751 - Sequence 433775 from Patent EP1572962.
JD373033 - Sequence 354057 from Patent EP1572962.
JD339799 - Sequence 320823 from Patent EP1572962.
JD205757 - Sequence 186781 from Patent EP1572962.
JD443126 - Sequence 424150 from Patent EP1572962.
JD424420 - Sequence 405444 from Patent EP1572962.
JD234005 - Sequence 215029 from Patent EP1572962.
JD360517 - Sequence 341541 from Patent EP1572962.
JD439232 - Sequence 420256 from Patent EP1572962.
JD338588 - Sequence 319612 from Patent EP1572962.
JD223160 - Sequence 204184 from Patent EP1572962.
JD362295 - Sequence 343319 from Patent EP1572962.
JD111106 - Sequence 92130 from Patent EP1572962.
JD210018 - Sequence 191042 from Patent EP1572962.
JD387920 - Sequence 368944 from Patent EP1572962.
JD074254 - Sequence 55278 from Patent EP1572962.
JD443268 - Sequence 424292 from Patent EP1572962.
JD470348 - Sequence 451372 from Patent EP1572962.
JD319020 - Sequence 300044 from Patent EP1572962.
JD157693 - Sequence 138717 from Patent EP1572962.
JD273034 - Sequence 254058 from Patent EP1572962.
JD174625 - Sequence 155649 from Patent EP1572962.
JD158162 - Sequence 139186 from Patent EP1572962.
JD219096 - Sequence 200120 from Patent EP1572962.
JD124076 - Sequence 105100 from Patent EP1572962.
JD059355 - Sequence 40379 from Patent EP1572962.
JD151572 - Sequence 132596 from Patent EP1572962.
JD397616 - Sequence 378640 from Patent EP1572962.
JD415932 - Sequence 396956 from Patent EP1572962.
JD195696 - Sequence 176720 from Patent EP1572962.
JD403986 - Sequence 385010 from Patent EP1572962.
JD408678 - Sequence 389702 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C170B_HUMAN, ENST00000414716.1, ENST00000414716.2, ENST00000414716.3, ENST00000414716.4, ENST00000414716.5, ENST00000414716.6, ENST00000414716.7, FAM68C, KIAA0284, NM_001112726, Q2KHR7, Q86TI7, Q9Y4F5, uc319kod.1, uc319kod.2
UCSC ID: ENST00000414716.8_6
RefSeq Accession: NM_001112726.3
Protein: Q9Y4F5 (aka K0284_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.