Human Gene CEP68 (ENST00000377990.7_10) from GENCODE V47lift37
  Description: centrosomal protein 68, transcript variant 1 (from RefSeq NM_015147.3)
Gencode Transcript: ENST00000377990.7_10
Gencode Gene: ENSG00000011523.15_14
Transcript (Including UTRs)
   Position: hg19 chr2:65,283,550-65,314,138 Size: 30,589 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr2:65,296,579-65,309,839 Size: 13,261 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:65,283,550-65,314,138)mRNA (may differ from genome)Protein (757 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CEP68_HUMAN
DESCRIPTION: RecName: Full=Centrosomal protein of 68 kDa; Short=Cep68;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome.
SEQUENCE CAUTION: Sequence=BAA25508.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CEP68
Diseases sorted by gene-association score: retinitis pigmentosa 28 (12)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.78 RPKM in Adipose - Subcutaneous
Total median expression: 131.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.00159-0.421 Picture PostScript Text
3' UTR -890.403370-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026696 - AKAP6/CEP68

SCOP Domains:
46966 - Spectrin repeat

ModBase Predicted Comparative 3D Structure on Q76N32
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding

Biological Process:
GO:0007098 centrosome cycle
GO:0010457 centriole-centriole cohesion
GO:0033365 protein localization to organelle

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  AB011154 - Homo sapiens KIAA0582 mRNA for KIAA0582 protein.
AK093846 - Homo sapiens cDNA FLJ36527 fis, clone TRACH2003941.
AK304110 - Homo sapiens cDNA FLJ61540 complete cds, highly similar to Centrosomal protein of 68 kDa.
AK000856 - Homo sapiens cDNA FLJ20849 fis, clone ADKA01706, highly similar to AB011154 Homo sapiens mRNA for KIAA0582 protein.
AK299373 - Homo sapiens cDNA FLJ58321 complete cds, highly similar to Centrosomal protein of 68 kDa.
AK301173 - Homo sapiens cDNA FLJ53411 partial cds, highly similar to Centrosomal protein of 68 kDa.
AK098786 - Homo sapiens cDNA FLJ25920 fis, clone CBR05013.
BX648774 - Homo sapiens mRNA; cDNA DKFZp686H16130 (from clone DKFZp686H16130).
BC030534 - Homo sapiens centrosomal protein 68kDa, mRNA (cDNA clone IMAGE:5219052), partial cds.
BC002982 - Homo sapiens centrosomal protein 68kDa, mRNA (cDNA clone MGC:2514 IMAGE:3543243), complete cds.
BC004873 - Homo sapiens centrosomal protein 68kDa, mRNA (cDNA clone MGC:11041 IMAGE:3678131), complete cds.
JD242104 - Sequence 223128 from Patent EP1572962.
AB383912 - Synthetic construct DNA, clone: pF1KSDA0582, Homo sapiens CEP68 gene for centrosomal protein 68 kDa, complete cds, without stop codon, in Flexi system.
AK094069 - Homo sapiens cDNA FLJ36750 fis, clone UTERU2017303.
AX748439 - Sequence 1964 from Patent EP1308459.
JD275415 - Sequence 256439 from Patent EP1572962.
JD475662 - Sequence 456686 from Patent EP1572962.
JD302957 - Sequence 283981 from Patent EP1572962.
DQ570865 - Homo sapiens piRNA piR-30977, complete sequence.
JD444835 - Sequence 425859 from Patent EP1572962.
JD444834 - Sequence 425858 from Patent EP1572962.
JD431525 - Sequence 412549 from Patent EP1572962.
JD233963 - Sequence 214987 from Patent EP1572962.
JD532685 - Sequence 513709 from Patent EP1572962.
JD532684 - Sequence 513708 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DRQ1, CEP68_HUMAN, D6W5F1, D6W5F2, ENST00000377990.1, ENST00000377990.2, ENST00000377990.3, ENST00000377990.4, ENST00000377990.5, ENST00000377990.6, KIAA0582, NM_015147, O60326, Q76N32, Q9BQ18, Q9UDM9, uc318nzt.1, uc318nzt.2
UCSC ID: ENST00000377990.7_10
RefSeq Accession: NM_015147.3
Protein: Q76N32 (aka CEP68_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.