Human Gene CEP72 (ENST00000264935.6_4) from GENCODE V47lift37

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Description: centrosomal protein 72, transcript variant 1 (from RefSeq NM_018140.4)
Gencode Transcript: ENST00000264935.6_4
Gencode Gene: ENSG00000112877.8_7
Transcript (Including UTRs)
Position: hg19 chr5:612,455-653,668 Size: 41,214 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr5:612,477-653,268 Size: 40,792 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:612,455-653,668)			mRNA (may differ from genome)		Protein (647 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CEP72_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein of 72 kDa; Short=Cep72; FUNCTION: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). SUBUNIT: Interacts with KIZ/PLK1S1. INTERACTION: O15265:ATXN7; NbExp=2; IntAct=EBI-739498, EBI-708350; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner. SIMILARITY: Belongs to the CEP72 family. SIMILARITY: Contains 3 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SEQUENCE CAUTION: Sequence=BAA91685.1; Type=Erroneous initiation; Sequence=BAA96043.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D000082 Acetaminophen D001151 Arsenic D001564 Benzo(a)pyrene D002117 Calcitriol D011794 Quercetin D013739 Testosterone D013749 Tetrachlorodibenzodioxin C011890 kojic acid C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.82 RPKM in Testis Total median expression: 69.77 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-1.70	22	-0.077	Picture	PostScript	Text
3' UTR	-83.30	400	-0.208	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies
IPR003603 - U2A'_phosphoprotein32A_C

Pfam Domains:
PF14580 - Leucine-rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1
161270 - PspA lactotransferrin-binding region

ModBase Predicted Comparative 3D Structure on Q9P209


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0007051 spindle organization GO:0007099 centriole replication GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0033566 gamma-tubulin complex localization GO:0097711 ciliary basal body docking GO:1904779 regulation of protein localization to centrosome Cellular Component: GO:0005737 cytoplasm GO:0005813 centrosome GO:0005815 microtubule organizing center GO:0005829 cytosol GO:0005856 cytoskeleton GO:0034451 centriolar satellite

Descriptions from all associated GenBank mRNAs


	AK001427 - Homo sapiens cDNA FLJ10565 fis, clone NT2RP2002954. BC000132 - Homo sapiens centrosomal protein 72kDa, mRNA (cDNA clone MGC:5307 IMAGE:2899944), complete cds. AB040952 - Homo sapiens KIAA1519 mRNA for KIAA1519 protein. AK299072 - Homo sapiens cDNA FLJ57567 complete cds, highly similar to Centrosomal protein of 72 kDa. AB384228 - Synthetic construct DNA, clone: pF1KSDA1519, Homo sapiens CEP72 gene for centrosomal protein 72 kDa, complete cds, without stop codon, in Flexi system. CU674056 - Synthetic construct Homo sapiens gateway clone IMAGE:100017441 5' read CEP72 mRNA. KJ894246 - Synthetic construct Homo sapiens clone ccsbBroadEn_03640 CEP72 gene, encodes complete protein. BC001750 - Homo sapiens centrosomal protein 72kDa, mRNA (cDNA clone IMAGE:3533449), partial cds. JD208419 - Sequence 189443 from Patent EP1572962. JD406502 - Sequence 387526 from Patent EP1572962. JD173845 - Sequence 154869 from Patent EP1572962. JD071611 - Sequence 52635 from Patent EP1572962. JD343572 - Sequence 324596 from Patent EP1572962. JD195551 - Sequence 176575 from Patent EP1572962. CU674862 - Synthetic construct Homo sapiens gateway clone IMAGE:100018310 5' read CEP72 mRNA. KJ906241 - Synthetic construct Homo sapiens clone ccsbBroadEn_15911 CEP72 gene, encodes complete protein. JD479720 - Sequence 460744 from Patent EP1572962. JD464783 - Sequence 445807 from Patent EP1572962. JD454227 - Sequence 435251 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9P209 (Reactome details) participates in the following event(s): R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle

Other Names for This Gene


	Alternate Gene Symbols: B4DR26, CEP72_HUMAN, ENST00000264935.1, ENST00000264935.2, ENST00000264935.3, ENST00000264935.4, ENST00000264935.5, KIAA1519, NM_018140, Q9BV03, Q9BWM3, Q9NVR4, Q9P209, uc317hww.1, uc317hww.2 UCSC ID: ENST00000264935.6_4 RefSeq Accession: NM_018140.4 Protein: Q9P209 (aka CEP72_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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