ID:CEP76_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein of 76 kDa; Short=Cep76; FUNCTION: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. SUBUNIT: Interacts with CEP110/CP110 and CEP97. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, centrosome, centriole. Note=Does not localize along the ciliary axoneme. DEVELOPMENTAL STAGE: Expressed at low level in G1 and is induced in S and G2 phase, during which point centrioles have already commenced duplication (at protein level). SIMILARITY: Belongs to the CEP76 family. SEQUENCE CAUTION: Sequence=BAG64223.1; Type=Erroneous termination; Positions=648; Note=Translated as Trp;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TAP6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK301964 - Homo sapiens cDNA FLJ60938 complete cds, highly similar to Centrosomal protein of 76 kDa. BC033026 - Homo sapiens centrosomal protein 76kDa, mRNA (cDNA clone IMAGE:5267551). BC026307 - Homo sapiens centrosomal protein 76kDa, mRNA (cDNA clone MGC:26034 IMAGE:4792211), complete cds. LF385255 - JP 2014500723-A/192758: Polycomb-Associated Non-Coding RNAs. JD469645 - Sequence 450669 from Patent EP1572962. AK022604 - Homo sapiens cDNA FLJ12542 fis, clone NT2RM4000534. AK303117 - Homo sapiens cDNA FLJ54339 complete cds, highly similar to Centrosomal protein of 76 kDa. LF343831 - JP 2014500723-A/151334: Polycomb-Associated Non-Coding RNAs. KJ894758 - Synthetic construct Homo sapiens clone ccsbBroadEn_04152 CEP76 gene, encodes complete protein. LF343832 - JP 2014500723-A/151335: Polycomb-Associated Non-Coding RNAs. AL833727 - Homo sapiens mRNA; cDNA DKFZp666F025 (from clone DKFZp666F025). DQ591816 - Homo sapiens piRNA piR-58928, complete sequence. AK298223 - Homo sapiens cDNA FLJ61148 complete cds, moderately similar to Centrosomal protein of 76 kDa. JD533323 - Sequence 514347 from Patent EP1572962. JD410548 - Sequence 391572 from Patent EP1572962. JD462627 - Sequence 443651 from Patent EP1572962. JD057765 - Sequence 38789 from Patent EP1572962. JD479861 - Sequence 460885 from Patent EP1572962. MA620832 - JP 2018138019-A/192758: Polycomb-Associated Non-Coding RNAs. MA579408 - JP 2018138019-A/151334: Polycomb-Associated Non-Coding RNAs. MA579409 - JP 2018138019-A/151335: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8TAP6 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
