Human Gene CEP85 (ENST00000451429.8_7) from GENCODE V47lift37
  Description: centrosomal protein 85, transcript variant 4 (from RefSeq NM_001319944.2)
Gencode Transcript: ENST00000451429.8_7
Gencode Gene: ENSG00000130695.16_11
Transcript (Including UTRs)
   Position: hg19 chr1:26,560,691-26,605,299 Size: 44,609 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr1:26,566,275-26,603,784 Size: 37,510 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:26,560,691-26,605,299)mRNA (may differ from genome)Protein (761 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CEP85_HUMAN
DESCRIPTION: RecName: Full=Centrosomal protein of 85 kDa; AltName: Full=Coiled-coil domain-containing protein 21;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus, nucleolus. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles.
SIMILARITY: Belongs to the CEP85 family.
SEQUENCE CAUTION: Sequence=BAB15203.1; Type=Erroneous initiation; Sequence=CAH71541.2; Type=Erroneous gene model prediction; Sequence=CAI15849.2; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.94 RPKM in Testis
Total median expression: 202.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.70133-0.321 Picture PostScript Text
3' UTR -542.601515-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q6P2H3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006469 negative regulation of protein kinase activity
GO:0007059 chromosome segregation
GO:0046602 regulation of mitotic centrosome separation

Cellular Component:
GO:0000242 pericentriolar material
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK299312 - Homo sapiens cDNA FLJ55640 complete cds, highly similar to Coiled-coil domain-containing protein 21.
AK024038 - Homo sapiens cDNA FLJ13976 fis, clone Y79AA1001594, weakly similar to HYALURONAN-MEDIATED MOTILITY RECEPTOR.
JD185186 - Sequence 166210 from Patent EP1572962.
BC064528 - Homo sapiens coiled-coil domain containing 21, mRNA (cDNA clone MGC:74928 IMAGE:5585742), complete cds.
JD142927 - Sequence 123951 from Patent EP1572962.
DQ600240 - Homo sapiens piRNA piR-38306, complete sequence.
AL133609 - Homo sapiens mRNA; cDNA DKFZp434L0117 (from clone DKFZp434L0117).
AK025653 - Homo sapiens cDNA: FLJ22000 fis, clone HEP06621.
AL137420 - Homo sapiens mRNA; cDNA DKFZp434P232 (from clone DKFZp434P232).
BC019902 - Homo sapiens coiled-coil domain containing 21, mRNA (cDNA clone IMAGE:4998532), complete cds.
KJ903101 - Synthetic construct Homo sapiens clone ccsbBroadEn_12495 CEP85 gene, encodes complete protein.
JD200731 - Sequence 181755 from Patent EP1572962.
JD272321 - Sequence 253345 from Patent EP1572962.
JD517039 - Sequence 498063 from Patent EP1572962.
JD453730 - Sequence 434754 from Patent EP1572962.
JD199826 - Sequence 180850 from Patent EP1572962.
JD058015 - Sequence 39039 from Patent EP1572962.
JD433387 - Sequence 414411 from Patent EP1572962.
JD316105 - Sequence 297129 from Patent EP1572962.
JD291078 - Sequence 272102 from Patent EP1572962.
JD556613 - Sequence 537637 from Patent EP1572962.
JD508228 - Sequence 489252 from Patent EP1572962.
JD130321 - Sequence 111345 from Patent EP1572962.
JD239632 - Sequence 220656 from Patent EP1572962.
JD120197 - Sequence 101221 from Patent EP1572962.
JD410254 - Sequence 391278 from Patent EP1572962.
JD432918 - Sequence 413942 from Patent EP1572962.
JD261522 - Sequence 242546 from Patent EP1572962.
JD349937 - Sequence 330961 from Patent EP1572962.
JD384235 - Sequence 365259 from Patent EP1572962.
JD162376 - Sequence 143400 from Patent EP1572962.
JD383601 - Sequence 364625 from Patent EP1572962.
JD520132 - Sequence 501156 from Patent EP1572962.
JD369068 - Sequence 350092 from Patent EP1572962.
JD022833 - Sequence 3857 from Patent EP1572962.
JD034759 - Sequence 15783 from Patent EP1572962.
DQ570947 - Homo sapiens piRNA piR-31059, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DRL1, CCDC21, CEP85 , CEP85_HUMAN, D3DPK4, ENST00000451429.1, ENST00000451429.2, ENST00000451429.3, ENST00000451429.4, ENST00000451429.5, ENST00000451429.6, ENST00000451429.7, F8W7K4, NM_001319944, Q5VY68, Q5VY70, Q6P2H3, Q9H6Q1, Q9H828, Q9UF52, uc320sup.1, uc320sup.2
UCSC ID: ENST00000451429.8_7
RefSeq Accession: NM_001319944.2
Protein: Q6P2H3 (aka CEP85_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.