ID:CEPT1_HUMAN DESCRIPTION: RecName: Full=Choline/ethanolaminephosphotransferase 1; Short=hCEPT1; EC=2.7.8.1; EC=2.7.8.2; FUNCTION: Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. CATALYTIC ACTIVITY: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. CATALYTIC ACTIVITY: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. COFACTOR: Magnesium or manganese. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=37 uM for CDP-choline; KM=101 uM for CDP-ethanolamine; Vmax=10.5 nmol/min/mg enzyme with CDP-choline as substrate; Vmax=4.35 nmol/min/mg enzyme with CDP-ethanolamine as substrate; PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I family. SEQUENCE CAUTION: Sequence=AAF61194.1; Type=Frameshift; Positions=276;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6K0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004142 diacylglycerol cholinephosphotransferase activity GO:0004307 ethanolaminephosphotransferase activity GO:0016740 transferase activity GO:0016780 phosphotransferase activity, for other substituted phosphate groups GO:0046872 metal ion binding
Biological Process: GO:0006629 lipid metabolic process GO:0006646 phosphatidylethanolamine biosynthetic process GO:0006656 phosphatidylcholine biosynthetic process GO:0006657 CDP-choline pathway GO:0008654 phospholipid biosynthetic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
