Human Gene CFL1 (ENST00000308162.10_9) from GENCODE V47lift37
  Description: cofilin 1 (from RefSeq NM_005507.3)
Gencode Transcript: ENST00000308162.10_9
Gencode Gene: ENSG00000172757.13_11
Transcript (Including UTRs)
   Position: hg19 chr11:65,622,144-65,625,651 Size: 3,508 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr11:65,622,807-65,625,570 Size: 2,764 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:65,622,144-65,625,651)mRNA (may differ from genome)Protein (166 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CFL1
Diseases sorted by gene-association score: corticobasal degeneration (2), autosomal dominant nonsyndromic deafness 20 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 228.89 RPKM in Whole Blood
Total median expression: 5667.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.0081-0.321 Picture PostScript Text
3' UTR -222.30663-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  LF208097 - JP 2014500723-A/15600: Polycomb-Associated Non-Coding RNAs.
BC018256 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:17447 IMAGE:3448134), complete cds.
BC012318 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:15952 IMAGE:3538185), complete cds.
JA482223 - Sequence 206 from Patent WO2011072091.
JE980515 - Sequence 206 from Patent EP2862929.
BC024975 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone IMAGE:4537759).
AK097690 - Homo sapiens cDNA FLJ40371 fis, clone TESTI2034931, highly similar to Cofilin-1.
X95404 - H.sapiens mRNA for non-muscle type cofilin.
BC012265 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:9272 IMAGE:3862540), complete cds.
AK303614 - Homo sapiens cDNA FLJ51435 complete cds, moderately similar to Cofilin-1.
BC011005 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:16554 IMAGE:4079579), complete cds.
U21909 - Homo sapiens cofilin mRNA, partial cds.
JD459014 - Sequence 440038 from Patent EP1572962.
LF372230 - JP 2014500723-A/179733: Polycomb-Associated Non-Coding RNAs.
JD243486 - Sequence 224510 from Patent EP1572962.
JD046698 - Sequence 27722 from Patent EP1572962.
LF372229 - JP 2014500723-A/179732: Polycomb-Associated Non-Coding RNAs.
JD124263 - Sequence 105287 from Patent EP1572962.
JD188514 - Sequence 169538 from Patent EP1572962.
LF372228 - JP 2014500723-A/179731: Polycomb-Associated Non-Coding RNAs.
JD157319 - Sequence 138343 from Patent EP1572962.
JD292751 - Sequence 273775 from Patent EP1572962.
JD537114 - Sequence 518138 from Patent EP1572962.
LF372227 - JP 2014500723-A/179730: Polycomb-Associated Non-Coding RNAs.
JD210544 - Sequence 191568 from Patent EP1572962.
D00682 - Homo sapiens mRNA for cofilin, complete cds.
KJ890901 - Synthetic construct Homo sapiens clone ccsbBroadEn_00295 CFL1 gene, encodes complete protein.
KJ896591 - Synthetic construct Homo sapiens clone ccsbBroadEn_05985 CFL1 gene, encodes complete protein.
BT006846 - Homo sapiens cofilin 1 (non-muscle) mRNA, complete cds.
DQ891769 - Synthetic construct clone IMAGE:100004399; FLH179761.01X; RZPDo839C06132D cofilin 1 (non-muscle) (CFL1) gene, encodes complete protein.
EU176624 - Synthetic construct Homo sapiens clone IMAGE:100011432; FLH179760.01L; RZPDo839C07254D cofilin 1 (non-muscle) (CFL1) gene, encodes complete protein.
EU794603 - Homo sapiens epididymis secretory protein Li 15 (HEL-S-15) mRNA, complete cds.
AB590274 - Synthetic construct DNA, clone: pFN21AE2285, Homo sapiens CFL1 gene for cofilin 1, without stop codon, in Flexi system.
JD025972 - Sequence 6996 from Patent EP1572962.
JD035281 - Sequence 16305 from Patent EP1572962.
LF372225 - JP 2014500723-A/179728: Polycomb-Associated Non-Coding RNAs.
LF372223 - JP 2014500723-A/179726: Polycomb-Associated Non-Coding RNAs.
LF372221 - JP 2014500723-A/179724: Polycomb-Associated Non-Coding RNAs.
HM370399 - Homo sapiens cofilin 1 (CFL1) mRNA, 5' UTR, alternatively spliced.
DQ581881 - Homo sapiens piRNA piR-49993, complete sequence.
D28345 - Homo sapiens mRNA for cofilin, 5'UTR region.
JD261561 - Sequence 242585 from Patent EP1572962.
MA607807 - JP 2018138019-A/179733: Polycomb-Associated Non-Coding RNAs.
MA607806 - JP 2018138019-A/179732: Polycomb-Associated Non-Coding RNAs.
MA607805 - JP 2018138019-A/179731: Polycomb-Associated Non-Coding RNAs.
MA607804 - JP 2018138019-A/179730: Polycomb-Associated Non-Coding RNAs.
MA607802 - JP 2018138019-A/179728: Polycomb-Associated Non-Coding RNAs.
MA607800 - JP 2018138019-A/179726: Polycomb-Associated Non-Coding RNAs.
MA607798 - JP 2018138019-A/179724: Polycomb-Associated Non-Coding RNAs.
MA443674 - JP 2018138019-A/15600: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000308162.1, ENST00000308162.2, ENST00000308162.3, ENST00000308162.4, ENST00000308162.5, ENST00000308162.6, ENST00000308162.7, ENST00000308162.8, ENST00000308162.9, HEL-S-15 , NM_005507, uc317ofy.1, uc317ofy.2, V9HWI5, V9HWI5_HUMAN
UCSC ID: ENST00000308162.10_9
RefSeq Accession: NM_005507.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.