ID:COF2_HUMAN DESCRIPTION: RecName: Full=Cofilin-2; AltName: Full=Cofilin, muscle isoform; FUNCTION: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity). INTERACTION: P60709:ACTB; NbExp=2; IntAct=EBI-351218, EBI-353944; P63261:ACTG1; NbExp=2; IntAct=EBI-351218, EBI-351292; SUBCELLULAR LOCATION: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (By similarity). TISSUE SPECIFICITY: Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues. PTM: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. DISEASE: Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 7 presents at birth with hypotonia and generalized weakness. Major motor milestones are delayed, but independent ambulation is achieved. SIMILARITY: Belongs to the actin-binding proteins ADF family. SIMILARITY: Contains 1 ADF-H domain. WEB RESOURCE: Name=Wikipedia; Note=Cofilin entry; URL="http://en.wikipedia.org/wiki/Cofilin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y281
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
