ID:CING_HUMAN DESCRIPTION: RecName: Full=Cingulin; FUNCTION: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. SUBUNIT: Homodimer (By similarity). Interacts with TJP1/ZO-1. SUBCELLULAR LOCATION: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex composed of tight and adherens junctions (By similarity). TISSUE SPECIFICITY: Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart. DOMAIN: Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1. SIMILARITY: Belongs to the cingulin family. SEQUENCE CAUTION: Sequence=AAF74498.1; Type=Erroneous initiation; Sequence=AAI52446.1; Type=Erroneous initiation; Sequence=BAA92557.1; Type=Erroneous initiation; Sequence=BAF82696.1; Type=Erroneous initiation; Sequence=CAI16590.1; Type=Erroneous initiation; Sequence=EAW53434.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2M7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ894434 - Synthetic construct Homo sapiens clone ccsbBroadEn_03828 CGN gene, encodes complete protein. DQ656045 - Homo sapiens clone UGL004-A-B1, mRNA sequence. DQ656046 - Homo sapiens clone UGL004-A-C1, mRNA sequence. AF263462 - Homo sapiens cingulin mRNA, complete cds. JD173344 - Sequence 154368 from Patent EP1572962. AK290007 - Homo sapiens cDNA FLJ77968 complete cds, highly similar to Homo sapiens cingulin (CGN), mRNA. AB037740 - Homo sapiens KIAA1319 mRNA for KIAA1319 protein. BC152445 - Homo sapiens cingulin, mRNA (cDNA clone MGC:176694 IMAGE:8862573), complete cds. BC146657 - Homo sapiens cingulin, mRNA (cDNA clone MGC:164854 IMAGE:40147940), complete cds. JD450211 - Sequence 431235 from Patent EP1572962. BC150604 - Homo sapiens cingulin, mRNA (cDNA clone MGC:183514 IMAGE:9056974), complete cds. AB385447 - Synthetic construct DNA, clone: pF1KA1319, Homo sapiens CGN gene for cingulin, complete cds, without stop codon, in Flexi system. AK096600 - Homo sapiens cDNA FLJ39281 fis, clone OCBBF2011067, highly similar to Homo sapiens cingulin mRNA. BX647343 - Homo sapiens mRNA; cDNA DKFZp779N1112 (from clone DKFZp779N1112). JD324311 - Sequence 305335 from Patent EP1572962. JD085841 - Sequence 66865 from Patent EP1572962. JD244580 - Sequence 225604 from Patent EP1572962. JD297811 - Sequence 278835 from Patent EP1572962. JD074103 - Sequence 55127 from Patent EP1572962. JD356091 - Sequence 337115 from Patent EP1572962. JD551870 - Sequence 532894 from Patent EP1572962. JD533528 - Sequence 514552 from Patent EP1572962. JD214803 - Sequence 195827 from Patent EP1572962. JD521138 - Sequence 502162 from Patent EP1572962. JD552811 - Sequence 533835 from Patent EP1572962. JD113288 - Sequence 94312 from Patent EP1572962. JD132594 - Sequence 113618 from Patent EP1572962. JD148663 - Sequence 129687 from Patent EP1572962. JD439694 - Sequence 420718 from Patent EP1572962. JD227207 - Sequence 208231 from Patent EP1572962. JD299884 - Sequence 280908 from Patent EP1572962. JD303891 - Sequence 284915 from Patent EP1572962. JD497450 - Sequence 478474 from Patent EP1572962. JD379004 - Sequence 360028 from Patent EP1572962. JD338516 - Sequence 319540 from Patent EP1572962. JD521941 - Sequence 502965 from Patent EP1572962. JD482269 - Sequence 463293 from Patent EP1572962. JD297542 - Sequence 278566 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9P2M7 (Reactome details) participates in the following event(s):
R-HSA-2134506 TGFBR1 is recruited to tight junctions by PARD6A R-NUL-2161147 TGFBR1 is recruited to tight junction by binding Pard6a R-HSA-2134519 TGFBR2 is recruited to tight junctions after TGF-beta stimulation R-HSA-2134532 TGFBR2 phosphorylates TGFBR1 and PARD6A R-HSA-2160932 SMURF1 binds phosphorylated PARD6A R-NUL-2161165 TGFBR2 phosphorylates Pard6a R-NUL-2161160 TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation R-HSA-2160935 SMURF1 ubiquitinates RHOA R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-9006936 Signaling by TGF-beta family members R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
