ID:CHCH3_HUMAN DESCRIPTION: RecName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial; FUNCTION: Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. SUBUNIT: Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form (By similarity). Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Interacts with CHCHD6. INTERACTION: Q15834:CCDC85B; NbExp=2; IntAct=EBI-743375, EBI-739674; P62136:PPP1CA; NbExp=2; IntAct=EBI-743375, EBI-357253; SUBCELLULAR LOCATION: Mitochondrion inner membrane; Lipid-anchor; Intermembrane side (By similarity). Cytoplasm. Nucleus. TISSUE SPECIFICITY: Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue. SIMILARITY: Contains 1 CHCH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NX63
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.