ID:CHM4C_HUMAN DESCRIPTION: RecName: Full=Charged multivesicular body protein 4c; AltName: Full=Chromatin-modifying protein 4c; Short=CHMP4c; AltName: Full=SNF7 homolog associated with Alix 3; AltName: Full=SNF7-3; Short=hSnf7-3; AltName: Full=Vacuolar protein sorting-associated protein 32-3; Short=Vps32-3; Short=hVps32-3; FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV- 1 p6- and p9-dependent virus release. SUBUNIT: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates. Interacts with CHMP2A. Interacts with CHMP4A. Interacts with CHMP4B. Interacts with CHMP6. Interacts with VPS4A. Interacts with PDCD6IP; the interaction is direct. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein (Probable). TISSUE SPECIFICITY: Expressed in heart, spleen and kidney. DOMAIN: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity). MISCELLANEOUS: Its overexpression strongly inhibits HIV-1 release. SIMILARITY: Belongs to the SNF7 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96CF2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042803 protein homodimerization activity
Biological Process: GO:0000920 cell separation after cytokinesis GO:0006997 nucleus organization GO:0007034 vacuolar transport GO:0007080 mitotic metaphase plate congression GO:0009838 abscission GO:0010824 regulation of centrosome duplication GO:0015031 protein transport GO:0016197 endosomal transport GO:0016236 macroautophagy GO:0019058 viral life cycle GO:0032466 negative regulation of cytokinesis GO:0036258 multivesicular body assembly GO:0039702 viral budding via host ESCRT complex GO:0044878 mitotic cytokinesis checkpoint GO:0050792 regulation of viral process GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway GO:1901673 regulation of mitotic spindle assembly GO:1902188 positive regulation of viral release from host cell
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
