Human Gene CHRNG (ENST00000651502.1_4) from GENCODE V47lift37
  Description: cholinergic receptor nicotinic gamma subunit (from RefSeq NM_005199.5)
Gencode Transcript: ENST00000651502.1_4
Gencode Gene: ENSG00000196811.13_9
Transcript (Including UTRs)
   Position: hg19 chr2:233,404,402-233,412,825 Size: 8,424 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr2:233,404,458-233,410,426 Size: 5,969 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:233,404,402-233,412,825)mRNA (may differ from genome)Protein (517 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ACHG_HUMAN
DESCRIPTION: RecName: Full=Acetylcholine receptor subunit gamma; Flags: Precursor;
FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
SUBUNIT: Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
DISEASE: Defects in CHRNG are a cause of multiple pterygium syndrome lethal type (MUPSL) [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
DISEASE: Defects in CHRNG are a cause of multiple pterygium syndrome Escobar variant (MUPSE) [MIM:265000]; also known as nonlethal type multiple pterygium syndrome. Escobar syndrome is a non-lethal form of arthrogryposis multiplex congenita. It is an autosomal recessive condition characterized by excessive webbing (pterygia), congenital contractures (arthrogryposis), and scoliosis. Variable other features include intrauterine death, congenital respiratory distress, short stature, faciocranial dysmorphism, ptosis, low-set ears, arachnodactyly and cryptorchism in males. Congenital contractures are common and may be caused by reduced fetal movements at sensitive times of development. Possible causes of decreased fetal mobility include space constraints such as oligohydramnion, drugs, metabolic conditions or neuromuscular disorders including myasthenia gravis. is a.
SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
SEQUENCE CAUTION: Sequence=AAY24103.1; Type=Erroneous gene model prediction; Sequence=CAA25861.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CHRNG";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CHRNG
Diseases sorted by gene-association score: escobar syndrome* (1594), multiple pterygium syndrome, lethal type* (1117), chrng-related disorders* (100), myasthenia gravis (21), neonatal myasthenia gravis (18), congenital contractures (11), fetal akinesia deformation sequence (8), oligohydramnios (8), degenerative myopia (7), microphthalmia, isolated 1 (7), cystic lymphangioma (7), refractive error (2), distal arthrogryposis (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.2056-0.254 Picture PostScript Text
3' UTR -957.002399-0.399 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006202 - Neur_chan_lig-bd
IPR006201 - Neur_channel
IPR006029 - Neurotrans-gated_channel_TM
IPR018000 - Neurotransmitter_ion_chnl_CS
IPR002394 - Nicotinic_acetylcholine_rcpt

Pfam Domains:
PF02931 - Neurotransmitter-gated ion-channel ligand binding domain
PF02932 - Neurotransmitter-gated ion-channel transmembrane region

SCOP Domains:
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore

ModBase Predicted Comparative 3D Structure on P07510
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity
GO:0005216 ion channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005515 protein binding
GO:0015267 channel activity
GO:0015276 ligand-gated ion channel activity
GO:0015464 acetylcholine receptor activity
GO:0022848 acetylcholine-gated cation-selective channel activity
GO:0042166 acetylcholine binding

Biological Process:
GO:0006811 ion transport
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007271 synaptic transmission, cholinergic
GO:0007274 neuromuscular synaptic transmission
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0098655 cation transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045202 synapse
GO:0045211 postsynaptic membrane


-  Descriptions from all associated GenBank mRNAs
  AK309340 - Homo sapiens cDNA, FLJ99381.
AK125362 - Homo sapiens cDNA FLJ43372 fis, clone NTONG2006324, highly similar to Acetylcholine receptor protein subunit gamma precursor.
KJ901340 - Synthetic construct Homo sapiens clone ccsbBroadEn_10734 CHRNG gene, encodes complete protein.
KR711878 - Synthetic construct Homo sapiens clone CCSBHm_00031615 CHRNG (CHRNG) mRNA, encodes complete protein.
KR711879 - Synthetic construct Homo sapiens clone CCSBHm_00031616 CHRNG (CHRNG) mRNA, encodes complete protein.
KR711880 - Synthetic construct Homo sapiens clone CCSBHm_00031617 CHRNG (CHRNG) mRNA, encodes complete protein.
BC111802 - Homo sapiens cholinergic receptor, nicotinic, gamma, mRNA (cDNA clone MGC:133376 IMAGE:40069605), complete cds.
JD082156 - Sequence 63180 from Patent EP1572962.
JD083315 - Sequence 64339 from Patent EP1572962.
JD136275 - Sequence 117299 from Patent EP1572962.
JD136276 - Sequence 117300 from Patent EP1572962.
JD139892 - Sequence 120916 from Patent EP1572962.
JD247807 - Sequence 228831 from Patent EP1572962.
JD326919 - Sequence 307943 from Patent EP1572962.
JD430944 - Sequence 411968 from Patent EP1572962.
JD558765 - Sequence 539789 from Patent EP1572962.
JD532258 - Sequence 513282 from Patent EP1572962.
JD442954 - Sequence 423978 from Patent EP1572962.
JD335360 - Sequence 316384 from Patent EP1572962.
JD335361 - Sequence 316385 from Patent EP1572962.
JD457164 - Sequence 438188 from Patent EP1572962.
JD388337 - Sequence 369361 from Patent EP1572962.
JD118440 - Sequence 99464 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_achPathway - Role of nicotinic acetylcholine receptors in the regulation of apoptosis

Reactome (by CSHL, EBI, and GO)

Protein P07510 (Reactome details) participates in the following event(s):

R-HSA-622325 Activation of highly sodium permeable nicotinic acetylcholine receptors
R-HSA-629588 Binding of acetylcholine to highly sodium permeable acetylcholine receptors
R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors
R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629602 Activation of Nicotinic Acetylcholine Receptors
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: ACHG_HUMAN, ACHRG, B3KWM8, NM_005199, P07510, Q14DU4, Q53RG2, uc328tau.1, uc328tau.2
UCSC ID: ENST00000651502.1_4
RefSeq Accession: NM_005199.5
Protein: P07510 (aka ACHG_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.