Human Gene CKS1B (ENST00000308987.6_4) from GENCODE V47lift37
  Description: CDC28 protein kinase regulatory subunit 1B, transcript variant 1 (from RefSeq NM_001826.3)
Gencode Transcript: ENST00000308987.6_4
Gencode Gene: ENSG00000173207.13_7
Transcript (Including UTRs)
   Position: hg19 chr1:154,947,157-154,951,727 Size: 4,571 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:154,947,222-154,951,253 Size: 4,032 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:154,947,157-154,951,727)mRNA (may differ from genome)Protein (79 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CKS1B
Diseases sorted by gene-association score: clear cell adenofibroma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.97 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 162.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.4065-0.329 Picture PostScript Text
3' UTR -129.40474-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000789 - Cyclin-dep_kinase_reg-sub

Pfam Domains:
PF01111 - Cyclin-dependent kinase regulatory subunit

SCOP Domains:
55637 - Cell cycle regulatory proteins

ModBase Predicted Comparative 3D Structure on Q5T178
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity

Biological Process:
GO:0007049 cell cycle
GO:0016310 phosphorylation
GO:0045859 regulation of protein kinase activity
GO:0051301 cell division


-  Descriptions from all associated GenBank mRNAs
  AK311769 - Homo sapiens cDNA, FLJ92030, Homo sapiens CDC28 protein kinase regulatory subunit 1B (CKS1B),mRNA.
BC070319 - Homo sapiens CDC28 protein kinase regulatory subunit 1B, mRNA (cDNA clone MGC:88322 IMAGE:4738841), complete cds.
BC070320 - Homo sapiens CDC28 protein kinase regulatory subunit 1B, mRNA (cDNA clone MGC:88323 IMAGE:6494754), complete cds.
AK307066 - Homo sapiens cDNA, FLJ97014.
BC007751 - Homo sapiens CDC28 protein kinase regulatory subunit 1B, mRNA (cDNA clone MGC:12835 IMAGE:4110344), complete cds.
AF279897 - Homo sapiens PNAS-143 mRNA, complete cds.
AF274941 - Homo sapiens PNAS-16 mRNA, complete cds.
BC015629 - Homo sapiens CDC28 protein kinase regulatory subunit 1B, mRNA (cDNA clone MGC:23080 IMAGE:3162564), complete cds.
X54941 - H.sapiens ckshs1 mRNA for Cks1 protein homologue.
JD019481 - Sequence 505 from Patent EP1572962.
JD035462 - Sequence 16486 from Patent EP1572962.
AB590248 - Synthetic construct DNA, clone: pFN21AB6711, Homo sapiens CKS1B gene for CDC28 protein kinase regulatory subunit 1B, without stop codon, in Flexi system.
DQ890700 - Synthetic construct clone IMAGE:100003330; FLH165272.01X; RZPDo839A04160D CDC28 protein kinase regulatory subunit 1B (CKS1B) gene, encodes complete protein.
DQ892972 - Synthetic construct Homo sapiens clone IMAGE:100005602; FLH263534.01X; RZPDo839B0977D CDC28 protein kinase regulatory subunit 1B (CKS1B) gene, encodes complete protein.
DQ893884 - Synthetic construct Homo sapiens clone IMAGE:100008344; FLH165268.01L; RZPDo839A04159D CDC28 protein kinase regulatory subunit 1B (CKS1B) gene, encodes complete protein.
DQ895958 - Synthetic construct Homo sapiens clone IMAGE:100010418; FLH188974.01L; RZPDo839A0464D CDC28 protein kinase regulatory subunit 1B (CKS1B) gene, encodes complete protein.
EU176486 - Synthetic construct Homo sapiens clone IMAGE:100011650; FLH264072.01L; RZPDo839F06257D CDC28 protein kinase regulatory subunit 1B (CKS1B) gene, encodes complete protein.
EU176487 - Synthetic construct Homo sapiens clone IMAGE:100011596; FLH263667.01L; RZPDo839C05159D CDC28 protein kinase regulatory subunit 1B (CKS1B) gene, encodes complete protein.
BT007196 - Homo sapiens CDC28 protein kinase regulatory subunit 1B mRNA, complete cds.
AF274943 - Homo sapiens PNAS-18 mRNA, complete cds.
JD024976 - Sequence 6000 from Patent EP1572962.
JD035727 - Sequence 16751 from Patent EP1572962.
JD297084 - Sequence 278108 from Patent EP1572962.
JD161468 - Sequence 142492 from Patent EP1572962.
JD025869 - Sequence 6893 from Patent EP1572962.
JD035967 - Sequence 16991 from Patent EP1572962.
JD201216 - Sequence 182240 from Patent EP1572962.
JD073792 - Sequence 54816 from Patent EP1572962.
JD235483 - Sequence 216507 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_p27Pathway - Regulation of p27 Phosphorylation during Cell Cycle Progression

-  Other Names for This Gene
  Alternate Gene Symbols: CKS1B , ENST00000308987.1, ENST00000308987.2, ENST00000308987.3, ENST00000308987.4, ENST00000308987.5, hCG_1739274 , NM_001826, Q5T178, Q5T178_HUMAN, uc317okt.1, uc317okt.2
UCSC ID: ENST00000308987.6_4
RefSeq Accession: NM_001826.3
Protein: Q5T178

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.