ID:CLCA2_HUMAN DESCRIPTION: RecName: Full=Calcium-activated chloride channel regulator 2; AltName: Full=Calcium-activated chloride channel family member 2; Short=hCLCA2; AltName: Full=Calcium-activated chloride channel protein 3; Short=CaCC-3; Short=hCaCC-3; Contains: RecName: Full=Calcium-activated chloride channel regulator 2, 109 kDa form; Contains: RecName: Full=Calcium-activated chloride channel regulator 2, 35 kDa form; Flags: Precursor; FUNCTION: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction. SUBCELLULAR LOCATION: Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release. TISSUE SPECIFICITY: Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules. INDUCTION: Significantly down-regulated in breast and colorectal cancer. PTM: The 141 kDa mature form is shedded, producing a 109 kDa form and a 35 kDa form. PTM: N-glycosylated. SIMILARITY: Belongs to the CLCR family. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UQC9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
