ID:CLPP_HUMAN DESCRIPTION: RecName: Full=Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial; EC=3.4.21.92; AltName: Full=Endopeptidase Clp; Flags: Precursor; FUNCTION: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. CATALYTIC ACTIVITY: Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). SUBUNIT: Tetradecamer that assembles into a two heptameric rings with a central cavity. SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. SIMILARITY: Belongs to the peptidase S14 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16740
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006508 proteolysis GO:0051260 protein homooligomerization GO:0051603 proteolysis involved in cellular protein catabolic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
