ID:NEUA_HUMAN DESCRIPTION: RecName: Full=N-acylneuraminate cytidylyltransferase; EC=2.7.7.43; AltName: Full=CMP-N-acetylneuraminic acid synthase; Short=CMP-NeuNAc synthase; FUNCTION: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). CATALYTIC ACTIVITY: CTP + N-acylneuraminate = diphosphate + CMP-N- acylneuraminate. PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism. SUBUNIT: Homotetramer; the active enzyme is formed by a dimer of dimers. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus and spleen. DOMAIN: The BC2 (basic cluster 2) motif is necessary and sufficient for the nuclear localization and contains the catalytic active site. The localization in the nucleus is however not required for the enzyme activity (By similarity). SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NFW8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
JF432877 - Synthetic construct Homo sapiens clone IMAGE:100074200 cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS) gene, encodes complete protein. KJ904820 - Synthetic construct Homo sapiens clone ccsbBroadEn_14214 CMAS-like gene, encodes complete protein. BC016609 - Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase, mRNA (cDNA clone MGC:5424 IMAGE:3448277), complete cds. AL832975 - Homo sapiens mRNA; cDNA DKFZp666I142 (from clone DKFZp666I142). JD257155 - Sequence 238179 from Patent EP1572962. JD445423 - Sequence 426447 from Patent EP1572962. AK022927 - Homo sapiens cDNA FLJ12865 fis, clone NT2RP2003643, moderately similar to Mus musculus mRNA for CMP-N-acetylneuraminic acid synthetase. JD282592 - Sequence 263616 from Patent EP1572962. AK222981 - Homo sapiens mRNA for cytidine 5'-monophosphate N-acetylneuraminic acid synthetase variant, clone: HSI02232. AF271388 - Homo sapiens CMP-N-acetylneuraminic acid synthase mRNA, complete cds. JD211709 - Sequence 192733 from Patent EP1572962. JD332977 - Sequence 314001 from Patent EP1572962. AF397212 - Homo sapiens cytidine monophospho-sialic acid synthase mRNA, complete cds. AK124990 - Homo sapiens cDNA FLJ43000 fis, clone BRTHA2012555, moderately similar to Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS). JD313284 - Sequence 294308 from Patent EP1572962. JD314896 - Sequence 295920 from Patent EP1572962. JD183318 - Sequence 164342 from Patent EP1572962. JD347609 - Sequence 328633 from Patent EP1572962. JD164537 - Sequence 145561 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-6138 - CMP-N-acetylneuraminate biosynthesis I (eukaryotes)
Reactome (by CSHL, EBI, and GO)
Protein Q8NFW8 (Reactome details) participates in the following event(s):
R-HSA-4084982 CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac R-HSA-4085001 Sialic acid metabolism R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
