ID:CNDP2_HUMAN DESCRIPTION: RecName: Full=Cytosolic non-specific dipeptidase; EC=3.4.13.18; AltName: Full=CNDP dipeptidase 2; AltName: Full=Glutamate carboxypeptidase-like protein 1; AltName: Full=Peptidase A; FUNCTION: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. CATALYTIC ACTIVITY: Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. COFACTOR: Binds 2 manganese ions per subunit (By similarity). ENZYME REGULATION: Inhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC(50)) is 13 uM. Inhibited by bestatin. The inhibitory concentration 50% (IC(50)) is 7 nM at pH 9.5. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM manganese ions); KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 uM manganese ions); KM=15 mM for carnosine (at pH 9.5 and in the presence of 0.1 mM manganese ions); SUBUNIT: Homodimer. INTERACTION: Q92597:NDRG1; NbExp=1; IntAct=EBI-1190734, EBI-716486; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. SIMILARITY: Belongs to the peptidase M20A family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96KP4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
