Human Gene CNTF (ENST00000361987.6_4) from GENCODE V47lift37
  Description: ciliary neurotrophic factor (from RefSeq NM_000614.4)
Gencode Transcript: ENST00000361987.6_4
Gencode Gene: ENSG00000242689.3_8
Transcript (Including UTRs)
   Position: hg19 chr11:58,390,138-58,393,206 Size: 3,069 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr11:58,390,226-58,391,995 Size: 1,770 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:58,390,138-58,393,206)mRNA (may differ from genome)Protein (200 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CNTF_HUMAN
DESCRIPTION: RecName: Full=Ciliary neurotrophic factor; Short=CNTF;
FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
SUBUNIT: Homodimer.
INTERACTION: P60228:EIF3E; NbExp=1; IntAct=EBI-1050897, EBI-347740; Q16394:EXT1; NbExp=1; IntAct=EBI-1050897, EBI-1046007; Q93063:EXT2; NbExp=1; IntAct=EBI-1050897, EBI-1047761; Q05084:ICA1; NbExp=1; IntAct=EBI-1050897, EBI-1046751; O75716:STK16; NbExp=1; IntAct=EBI-1050897, EBI-749295; P40337:VHL; NbExp=1; IntAct=EBI-1050897, EBI-301246;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Nervous system.
SIMILARITY: Belongs to the CNTF family.
WEB RESOURCE: Name=Wikipedia; Note=Ciliary neurotrophic factor entry; URL="http://en.wikipedia.org/wiki/Ciliary_neurotrophic_factor";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CNTF
Diseases sorted by gene-association score: motor neuron disease (11), epilepsy, familial temporal lobe, 2 (9), amyotrophic lateral sclerosis 19 (8), cerebral artery occlusion (7), diabetic neuropathy (7), cold-induced sweating syndrome (6), optic neuritis (6), learning disability (5), amyotrophic lateral sclerosis 1 (5), tetanus neonatorum (5), wallerian degeneration (4), huntington disease (3), central nervous system disease (2), retinitis pigmentosa (2), obesity (1), achromatopsia (1), parkinson disease, late-onset (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.2088-0.207 Picture PostScript Text
3' UTR -337.601211-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR000151 - Ciliary_neurotrophic_fac_CNTF

Pfam Domains:
PF01110 - Ciliary neurotrophic factor

SCOP Domains:
47266 - 4-helical cytokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1CNT - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P26441
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005138 interleukin-6 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity

Biological Process:
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0030154 cell differentiation
GO:0040007 growth
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043524 negative regulation of neuron apoptotic process
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0046668 regulation of retinal cell programmed cell death
GO:0048143 astrocyte activation
GO:0048644 muscle organ morphogenesis
GO:0048666 neuron development
GO:0048680 positive regulation of axon regeneration
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0030424 axon
GO:0097058 CRLF-CLCF1 complex


-  Descriptions from all associated GenBank mRNAs
  AB057443 - Homo sapiens ZFP91-CNTF mRNA for testis specific ZFP91, complete cds.
BC069167 - Homo sapiens ciliary neurotrophic factor, mRNA (cDNA clone MGC:95441 IMAGE:7217016), complete cds.
BC068030 - Homo sapiens ciliary neurotrophic factor, mRNA (cDNA clone MGC:75418 IMAGE:30407481), complete cds.
AK314118 - Homo sapiens cDNA, FLJ94809, Homo sapiens ciliary neurotrophic factor (CNTF), mRNA.
JD384923 - Sequence 365947 from Patent EP1572962.
BC074963 - Homo sapiens ciliary neurotrophic factor, mRNA (cDNA clone MGC:104058 IMAGE:30915506), complete cds.
BC074964 - Homo sapiens ciliary neurotrophic factor, mRNA (cDNA clone MGC:103900 IMAGE:30915287), complete cds.
JD276940 - Sequence 257964 from Patent EP1572962.
JD348505 - Sequence 329529 from Patent EP1572962.
CU686605 - Synthetic construct Homo sapiens gateway clone IMAGE:100022795 5' read CNTF mRNA.
KJ890946 - Synthetic construct Homo sapiens clone ccsbBroadEn_00340 CNTF gene, encodes complete protein.
S72921 - CNTF=ciliary neurotrophic factor [human, mRNA Partial Mutant, 607 nt].
JD057532 - Sequence 38556 from Patent EP1572962.
JD084827 - Sequence 65851 from Patent EP1572962.
JD515906 - Sequence 496930 from Patent EP1572962.
JD180891 - Sequence 161915 from Patent EP1572962.
JD221500 - Sequence 202524 from Patent EP1572962.
JD231771 - Sequence 212795 from Patent EP1572962.
JD073203 - Sequence 54227 from Patent EP1572962.
JD084488 - Sequence 65512 from Patent EP1572962.
JD109451 - Sequence 90475 from Patent EP1572962.
JD556103 - Sequence 537127 from Patent EP1572962.
JD258161 - Sequence 239185 from Patent EP1572962.
JD300295 - Sequence 281319 from Patent EP1572962.
JD491484 - Sequence 472508 from Patent EP1572962.
JD508557 - Sequence 489581 from Patent EP1572962.
JD359145 - Sequence 340169 from Patent EP1572962.
JD231193 - Sequence 212217 from Patent EP1572962.
JD103827 - Sequence 84851 from Patent EP1572962.
JD327456 - Sequence 308480 from Patent EP1572962.
JD087703 - Sequence 68727 from Patent EP1572962.
JD427992 - Sequence 409016 from Patent EP1572962.
JD506590 - Sequence 487614 from Patent EP1572962.
JD327142 - Sequence 308166 from Patent EP1572962.
JD532887 - Sequence 513911 from Patent EP1572962.
JD367283 - Sequence 348307 from Patent EP1572962.
JD175496 - Sequence 156520 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P26441 (Reactome details) participates in the following event(s):

R-HSA-5696491 CNTF binds CNTFR complex
R-HSA-6783530 gp130:JAKs bind CNTFR
R-HSA-6783556 LIFR:JAKs bind gp130:JAKs:CNTFR
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-6783589 Interleukin-6 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B2RAB2, CNTF_HUMAN, ENST00000361987.1, ENST00000361987.2, ENST00000361987.3, ENST00000361987.4, ENST00000361987.5, NM_000614, P26441, uc318clq.1, uc318clq.2
UCSC ID: ENST00000361987.6_4
RefSeq Accession: NM_000614.4
Protein: P26441 (aka CNTF_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.