Human Gene COA7 (ENST00000371538.5_7) from GENCODE V47lift37
  Description: cytochrome c oxidase assembly factor 7 (from RefSeq NM_023077.3)
Gencode Transcript: ENST00000371538.5_7
Gencode Gene: ENSG00000162377.6_11
Transcript (Including UTRs)
   Position: hg19 chr1:53,150,121-53,164,019 Size: 13,899 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr1:53,153,392-53,163,998 Size: 10,607 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:53,150,121-53,164,019)mRNA (may differ from genome)Protein (231 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SELR1_HUMAN
DESCRIPTION: RecName: Full=Sel1 repeat-containing protein 1; AltName: Full=Beta-lactamase hcp-like protein;
SIMILARITY: Belongs to the hcp beta-lactamase family.
SIMILARITY: Contains 5 Sel1-like repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: COA7
Diseases sorted by gene-association score: mitochondrial complex iv deficiency* (274)
* = Manually curated disease association

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.19 RPKM in Cells - Cultured fibroblasts
Total median expression: 159.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.6021-0.076 Picture PostScript Text
3' UTR -982.003271-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006597 - Sel1-like
IPR011990 - TPR-like_helical

Pfam Domains:
PF08238 - Sel1 repeat

SCOP Domains:
81901 - HCP-like

ModBase Predicted Comparative 3D Structure on Q96BR5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space


-  Descriptions from all associated GenBank mRNAs
  AK023237 - Homo sapiens cDNA FLJ13175 fis, clone NT2RP3003842.
JD137124 - Sequence 118148 from Patent EP1572962.
JD097711 - Sequence 78735 from Patent EP1572962.
JD450885 - Sequence 431909 from Patent EP1572962.
JD100005 - Sequence 81029 from Patent EP1572962.
JD212796 - Sequence 193820 from Patent EP1572962.
JD142553 - Sequence 123577 from Patent EP1572962.
JD266227 - Sequence 247251 from Patent EP1572962.
JD199240 - Sequence 180264 from Patent EP1572962.
JD249912 - Sequence 230936 from Patent EP1572962.
JD148344 - Sequence 129368 from Patent EP1572962.
JD463855 - Sequence 444879 from Patent EP1572962.
JD478604 - Sequence 459628 from Patent EP1572962.
JD543291 - Sequence 524315 from Patent EP1572962.
JD366560 - Sequence 347584 from Patent EP1572962.
JD105962 - Sequence 86986 from Patent EP1572962.
JD517733 - Sequence 498757 from Patent EP1572962.
JD149422 - Sequence 130446 from Patent EP1572962.
AK022501 - Homo sapiens cDNA FLJ12439 fis, clone NT2RM1000127.
AK225041 - Homo sapiens mRNA for hypothetical protein LOC65260 variant, clone: adSE00629.
JD358633 - Sequence 339657 from Patent EP1572962.
JD385844 - Sequence 366868 from Patent EP1572962.
AK225087 - Homo sapiens mRNA for hypothetical protein LOC65260 variant, clone: CAS04236.
BC005992 - Homo sapiens chromosome 1 open reading frame 163, mRNA (cDNA clone IMAGE:4048738), containing frame-shift errors.
JD158410 - Sequence 139434 from Patent EP1572962.
BC015313 - Homo sapiens chromosome 1 open reading frame 163, mRNA (cDNA clone MGC:21050 IMAGE:4430419), complete cds.
GQ901023 - Homo sapiens clone HEL-T-135 epididymis secretory sperm binding protein mRNA, complete cds.
JD563148 - Sequence 544172 from Patent EP1572962.
JD244208 - Sequence 225232 from Patent EP1572962.
KJ899499 - Synthetic construct Homo sapiens clone ccsbBroadEn_08893 SELRC1 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: C1orf163, COA7_HUMAN, ENST00000371538.1, ENST00000371538.2, ENST00000371538.3, ENST00000371538.4, NM_023077, Q0P6I7, Q96BR5, Q9H9Z9, RESA1, SELRC1, uc318jfk.1, uc318jfk.2
UCSC ID: ENST00000371538.5_7
RefSeq Accession: NM_023077.3
Protein: Q96BR5 (aka SELR1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.