ID:COG5_HUMAN DESCRIPTION: RecName: Full=Conserved oligomeric Golgi complex subunit 5; Short=COG complex subunit 5; AltName: Full=13S Golgi transport complex 90 kDa subunit; Short=GTC-90; AltName: Full=Component of oligomeric Golgi complex 5; AltName: Full=Golgi transport complex 1; FUNCTION: Required for normal Golgi function (By similarity). SUBUNIT: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization (By similarity). INTERACTION: Q9H9E3:COG4; NbExp=2; IntAct=EBI-389502, EBI-368382; P83436:COG7; NbExp=2; IntAct=EBI-389502, EBI-389534; SUBCELLULAR LOCATION: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. DISEASE: Defects in COG5 are the cause of congenital disorder of glycosylation type 2I (CDG2I) [MIM:613612]. A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Congenital disorder of glycosylation type 2I is characterized by mild neurological impairments. SIMILARITY: Belongs to the COG5 family. CAUTION: It is uncertain whether Met-1 or Met-32 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48334 - DNA repair protein MutS, domain III 58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain
ModBase Predicted Comparative 3D Structure on Q9UP83
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK022835 - Homo sapiens cDNA FLJ12773 fis, clone NT2RP2001660, highly similar to Conserved oligomeric Golgi complex component 5. AF058718 - Homo sapiens putative 13 S Golgi transport complex 90kD subunit brain-specific isoform mRNA, complete cds. AK314270 - Homo sapiens cDNA, FLJ95023. BC068540 - Homo sapiens component of oligomeric golgi complex 5, mRNA (cDNA clone MGC:87389 IMAGE:4374289), complete cds. HQ258000 - Synthetic construct Homo sapiens clone IMAGE:100072309 component of oligomeric golgi complex 5 (COG5), transcript variant 3 (COG5) gene, encodes complete protein. KJ898221 - Synthetic construct Homo sapiens clone ccsbBroadEn_07615 COG5 gene, encodes complete protein. LF209511 - JP 2014500723-A/17014: Polycomb-Associated Non-Coding RNAs. LF213998 - JP 2014500723-A/21501: Polycomb-Associated Non-Coding RNAs. MA449575 - JP 2018138019-A/21501: Polycomb-Associated Non-Coding RNAs. MA445088 - JP 2018138019-A/17014: Polycomb-Associated Non-Coding RNAs. CU692563 - Synthetic construct Homo sapiens gateway clone IMAGE:100022320 3' read HBP1 mRNA. CU677822 - Synthetic construct Homo sapiens gateway clone IMAGE:100017382 3' read HBP1 mRNA. AK123726 - Homo sapiens cDNA FLJ41732 fis, clone HLUNG2017546. JD090183 - Sequence 71207 from Patent EP1572962. JD235501 - Sequence 216525 from Patent EP1572962. JD309860 - Sequence 290884 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UP83 (Reactome details) participates in the following event(s):
R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane R-HSA-8847544 The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering R-HSA-8849748 The COG complex binds RABs at the Golgi membrane R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811438 Intra-Golgi traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
