Human Gene COQ10B (ENST00000263960.7_6) from GENCODE V47lift37
  Description: coenzyme Q10B, transcript variant 1 (from RefSeq NM_025147.5)
Gencode Transcript: ENST00000263960.7_6
Gencode Gene: ENSG00000115520.9_10
Transcript (Including UTRs)
   Position: hg19 chr2:198,318,276-198,340,034 Size: 21,759 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr2:198,318,285-198,338,648 Size: 20,364 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:198,318,276-198,340,034)mRNA (may differ from genome)Protein (238 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CQ10B_HUMAN
DESCRIPTION: RecName: Full=Coenzyme Q-binding protein COQ10 homolog B, mitochondrial; Flags: Precursor;
FUNCTION: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
SUBUNIT: Interacts with coenzyme Q (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the COQ10 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.80 RPKM in Adrenal Gland
Total median expression: 443.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -342.601386-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005031 - Polyket_cyc
IPR023393 - START-like_dom

Pfam Domains:
PF03364 - Polyketide cyclase / dehydrase and lipid transport

SCOP Domains:
55961 - Bet v1-like

ModBase Predicted Comparative 3D Structure on Q9H8M1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0048039 ubiquinone binding

Biological Process:
GO:0006744 ubiquinone biosynthetic process
GO:0045333 cellular respiration

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF205207 - JP 2014500723-A/12710: Polycomb-Associated Non-Coding RNAs.
BC022453 - Homo sapiens coenzyme Q10 homolog B (S. cerevisiae), mRNA (cDNA clone MGC:26023 IMAGE:4796819), complete cds.
AK023510 - Homo sapiens cDNA FLJ13448 fis, clone PLACE1002993.
CU692626 - Synthetic construct Homo sapiens gateway clone IMAGE:100023261 5' read COQ10B mRNA.
HQ448168 - Synthetic construct Homo sapiens clone IMAGE:100071558; CCSB001127_01 coenzyme Q10 homolog B (S. cerevisiae) (COQ10B) gene, encodes complete protein.
KJ894798 - Synthetic construct Homo sapiens clone ccsbBroadEn_04192 COQ10B gene, encodes complete protein.
LF317758 - JP 2014500723-A/125261: Polycomb-Associated Non-Coding RNAs.
AK294093 - Homo sapiens cDNA FLJ52258 complete cds, highly similar to Protein COQ10 B, mitochondrial precursor.
AK308977 - Homo sapiens cDNA, FLJ99018.
JD292345 - Sequence 273369 from Patent EP1572962.
JD313261 - Sequence 294285 from Patent EP1572962.
JD110965 - Sequence 91989 from Patent EP1572962.
JD212393 - Sequence 193417 from Patent EP1572962.
JD412748 - Sequence 393772 from Patent EP1572962.
JD512704 - Sequence 493728 from Patent EP1572962.
JD491218 - Sequence 472242 from Patent EP1572962.
JD101651 - Sequence 82675 from Patent EP1572962.
JD422035 - Sequence 403059 from Patent EP1572962.
JD344158 - Sequence 325182 from Patent EP1572962.
JD291766 - Sequence 272790 from Patent EP1572962.
JD291767 - Sequence 272791 from Patent EP1572962.
JD421938 - Sequence 402962 from Patent EP1572962.
JD340932 - Sequence 321956 from Patent EP1572962.
JD097199 - Sequence 78223 from Patent EP1572962.
JD050346 - Sequence 31370 from Patent EP1572962.
JD373692 - Sequence 354716 from Patent EP1572962.
JD074559 - Sequence 55583 from Patent EP1572962.
JD238501 - Sequence 219525 from Patent EP1572962.
JD238503 - Sequence 219527 from Patent EP1572962.
JD238502 - Sequence 219526 from Patent EP1572962.
JD055233 - Sequence 36257 from Patent EP1572962.
JD125699 - Sequence 106723 from Patent EP1572962.
JD096421 - Sequence 77445 from Patent EP1572962.
JD308893 - Sequence 289917 from Patent EP1572962.
JD138272 - Sequence 119296 from Patent EP1572962.
JD175862 - Sequence 156886 from Patent EP1572962.
JD332278 - Sequence 313302 from Patent EP1572962.
JD332277 - Sequence 313301 from Patent EP1572962.
JD448254 - Sequence 429278 from Patent EP1572962.
JD351644 - Sequence 332668 from Patent EP1572962.
JD392958 - Sequence 373982 from Patent EP1572962.
JD295155 - Sequence 276179 from Patent EP1572962.
JD547932 - Sequence 528956 from Patent EP1572962.
JD047112 - Sequence 28136 from Patent EP1572962.
MA440784 - JP 2018138019-A/12710: Polycomb-Associated Non-Coding RNAs.
MA553335 - JP 2018138019-A/125261: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B7Z1Y4, CQ10B_HUMAN, ENST00000263960.1, ENST00000263960.2, ENST00000263960.3, ENST00000263960.4, ENST00000263960.5, ENST00000263960.6, NM_025147, Q9H8M1, uc317hns.1, uc317hns.2
UCSC ID: ENST00000263960.7_6
RefSeq Accession: NM_025147.5
Protein: Q9H8M1 (aka CQ10B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.