Human Gene COQ5 (ENST00000288532.11_7) from GENCODE V47lift37

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Description: coenzyme Q5, methyltransferase (from RefSeq NM_032314.4)
Gencode Transcript: ENST00000288532.11_7
Gencode Gene: ENSG00000110871.15_11
Transcript (Including UTRs)
Position: hg19 chr12:120,941,082-120,966,961 Size: 25,880 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr12:120,941,587-120,966,944 Size: 25,358 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:120,941,082-120,966,961)			mRNA (may differ from genome)		Protein (327 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: COQ5_HUMAN DESCRIPTION: RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; EC=2.1.1.201; AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5; Flags: Precursor; FUNCTION: Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity). CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all- trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6- methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. SUBCELLULAR LOCATION: Mitochondrion (By similarity). SIMILARITY: Belongs to the methyltransferase superfamily. UbiE family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D016572 Cyclosporine D000082 Acetaminophen D016604 Aflatoxin B1 D002259 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone D002794 Choline D019327 Copper Sulfate D004997 Ethinyl Estradiol D005485 Flutamide D005492 Folic Acid more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 26.13 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 634.33 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-1.70	17	-0.100	Picture	PostScript	Text
3' UTR	-132.20	505	-0.262	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004033 - UbiE/COQ5_MeTrFase
IPR023576 - UbiE/COQ5_MeTrFase_CS
IPR025765 - UbiE/COQ5_MeTrFase_dom

Pfam Domains:
PF01209 - ubiE/COQ5 methyltransferase family
PF08241 - Methyltransferase domain
PF08242 - Methyltransferase domain
PF13489 - Methyltransferase domain
PF13649 - Methyltransferase domain
PF13847 - Methyltransferase domain

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q5HYK3


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0008168 methyltransferase activity GO:0016740 transferase activity GO:0102005 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Biological Process: GO:0006744 ubiquinone biosynthetic process GO:0032259 methylation Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix GO:0016020 membrane GO:0032991 macromolecular complex

Descriptions from all associated GenBank mRNAs


	AK293656 - Homo sapiens cDNA FLJ50117 complete cds, highly similar to Ubiquinone biosynthesis methyltransferase COQ5, mitochondrial precursor (EC 2.1.1.-). BC004916 - Homo sapiens coenzyme Q5 homolog, methyltransferase (S. cerevisiae), mRNA (cDNA clone IMAGE:3538702), partial cds. AK222610 - Homo sapiens mRNA for hypothetical protein MGC4767 variant, clone: CAS10422. BC107874 - Homo sapiens coenzyme Q5 homolog, methyltransferase (S. cerevisiae), mRNA (cDNA clone MGC:104303 IMAGE:6452052), complete cds. AK057777 - Homo sapiens cDNA FLJ25048 fis, clone CBL03993. EU700459 - Homo sapiens COQ5 mRNA, complete cds. BX647562 - Homo sapiens mRNA; cDNA DKFZp313K0719 (from clone DKFZp313K0719). AK225242 - Homo sapiens mRNA for hypothetical protein LOC84274 variant, clone: DMC02742. JD444512 - Sequence 425536 from Patent EP1572962. JD540692 - Sequence 521716 from Patent EP1572962. AK298214 - Homo sapiens cDNA FLJ55122 complete cds, highly similar to Ubiquinone biosynthesis methyltransferaseCOQ5, mitochondrial precursor (EC 2.1.1.-). JD064924 - Sequence 45948 from Patent EP1572962. JD068225 - Sequence 49249 from Patent EP1572962. JD205608 - Sequence 186632 from Patent EP1572962. AK315681 - Homo sapiens cDNA, FLJ96775. KJ899777 - Synthetic construct Homo sapiens clone ccsbBroadEn_09171 COQ5 gene, encodes complete protein. AB590926 - Synthetic construct DNA, clone: pFN21AE1810, Homo sapiens COQ5 gene for coenzyme Q5 homolog, methyltransferase, without stop codon, in Flexi system. JD197560 - Sequence 178584 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-5872 - ubiquinol-10 biosynthesis Reactome (by CSHL, EBI, and GO) Protein Q5HYK3 (Reactome details) participates in the following event(s): R-HSA-2162188 MDMQ10H2 is methylated to DMQ10H2 by COQ5 R-HSA-2142789 Ubiquinol biosynthesis R-HSA-8978934 Metabolism of cofactors R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: B2RDU9, B3GK62, B4DEJ4, COQ5 , COQ5_HUMAN, ENST00000288532.1, ENST00000288532.10, ENST00000288532.2, ENST00000288532.3, ENST00000288532.4, ENST00000288532.5, ENST00000288532.6, ENST00000288532.7, ENST00000288532.8, ENST00000288532.9, NM_032314, Q32Q28, Q53HH0, Q5HYK3, Q96LV1, Q9BSP8, uc317kqb.1, uc317kqb.2 UCSC ID: ENST00000288532.11_7 RefSeq Accession: NM_032314.4 Protein: Q5HYK3 (aka COQ5_HUMAN)

GeneReviews for This Gene


	GeneReviews article(s) related to gene COQ5: coq10-def (Primary Coenzyme Q10 Deficiency Overview)

Gene Model Information


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Methods, Credits, and Use Restrictions


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