Human Gene CORT (ENST00000377049.4_4) from GENCODE V47lift37
  Description: cortistatin (from RefSeq NM_001302.5)
Gencode Transcript: ENST00000377049.4_4
Gencode Gene: ENSG00000241563.4_7
Transcript (Including UTRs)
   Position: hg19 chr1:10,510,088-10,512,055 Size: 1,968 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr1:10,510,281-10,511,652 Size: 1,372 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:10,510,088-10,512,055)mRNA (may differ from genome)Protein (105 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CORT_HUMAN
DESCRIPTION: RecName: Full=Cortistatin; Contains: RecName: Full=Cortistatin-29; Contains: RecName: Full=Cortistatin-17; Flags: Precursor;
FUNCTION: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in a subset of GABAergic cells in the cortex and hippocampus.
SIMILARITY: Belongs to the somatostatin family.
SEQUENCE CAUTION: Sequence=AAI19725.1; Type=Erroneous initiation; Sequence=AAI19726.1; Type=Erroneous initiation; Sequence=AAQ89950.1; Type=Erroneous initiation; Sequence=CAI19195.1; Type=Erroneous initiation; Sequence=EAW71650.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CORT
Diseases sorted by gene-association score: pituitary adenoma, prolactin-secreting (3), intestinal disease (2), neuroblastoma (2), corticosteroid-binding globulin deficiency (2), mental depression (1), separation anxiety disorder (1), kleine-levin hibernation syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.91 RPKM in Brain - Caudate (basal ganglia)
Total median expression: 77.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.80193-0.242 Picture PostScript Text
3' UTR -75.20403-0.187 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018142 - Somatostatin/Cortistatin_C

Pfam Domains:
PF03002 - Somatostatin/Cortistatin family

ModBase Predicted Comparative 3D Structure on O00230
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001664 G-protein coupled receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding

Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0010469 regulation of receptor activity
GO:0000712 resolution of meiotic recombination intermediates
GO:0006312 mitotic recombination
GO:0031297 replication fork processing
GO:0036297 interstrand cross-link repair

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0043240 Fanconi anaemia nuclear complex
GO:0071821 FANCM-MHF complex


-  Descriptions from all associated GenBank mRNAs
  AF521016 - Homo sapiens unknown mRNA.
AF516753 - Homo sapiens unknown mRNA.
AY358561 - Homo sapiens DNA44175 CORT (UNQ307) mRNA, partial cds.
AF086433 - Homo sapiens full length insert cDNA clone ZD80A01.
BC119724 - Homo sapiens cortistatin, mRNA (cDNA clone MGC:149756 IMAGE:40118115), complete cds.
BC119725 - Homo sapiens cortistatin, mRNA (cDNA clone MGC:149757 IMAGE:40118117), complete cds.
AB590589 - Synthetic construct DNA, clone: pFN21AE1641, Homo sapiens CORT gene for cortistatin, without stop codon, in Flexi system.
KJ890953 - Synthetic construct Homo sapiens clone ccsbBroadEn_00347 CORT gene, encodes complete protein.
AF013252 - Homo sapiens preprocortistatin (Cort) mRNA, complete cds.
JD118024 - Sequence 99048 from Patent EP1572962.
BC040034 - Homo sapiens cortistatin, mRNA (cDNA clone IMAGE:5194613), partial cds.
JD464166 - Sequence 445190 from Patent EP1572962.
AB000263 - Homo sapiens mRNA for prepro cortistatin like peptide, complete cds.
JD229046 - Sequence 210070 from Patent EP1572962.
JD267749 - Sequence 248773 from Patent EP1572962.
JD083989 - Sequence 65013 from Patent EP1572962.
JD431273 - Sequence 412297 from Patent EP1572962.
JD266639 - Sequence 247663 from Patent EP1572962.
JD500507 - Sequence 481531 from Patent EP1572962.
JD288592 - Sequence 269616 from Patent EP1572962.
JD357312 - Sequence 338336 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O00230 (Reactome details) participates in the following event(s):

R-HSA-374758 Somatostatin receptors bind somatostatin and cortistatin
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CORT_HUMAN, ENST00000377049.1, ENST00000377049.2, ENST00000377049.3, NM_001302, O00230, Q5T6G0, Q6UX11, uc318nix.1, uc318nix.2, UNQ307/PRO350
UCSC ID: ENST00000377049.4_4
RefSeq Accession: NM_001302.5
Protein: O00230 (aka CORT_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.