Human Gene COX7A2 (ENST00000684430.2_5) from GENCODE V47lift37
  Description: cytochrome c oxidase subunit 7A2, transcript variant 6 (from RefSeq NR_158784.1)
Gencode Transcript: ENST00000684430.2_5
Gencode Gene: ENSG00000112695.13_16
Transcript (Including UTRs)
   Position: hg19 chr6:75,947,503-75,953,517 Size: 6,015 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr6:75,947,646-75,953,450 Size: 5,805 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:75,947,503-75,953,517)mRNA (may differ from genome)Protein (83 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CX7A2_HUMAN
DESCRIPTION: RecName: Full=Cytochrome c oxidase subunit 7A2, mitochondrial; AltName: Full=Cytochrome c oxidase subunit VIIa-liver/heart; Short=Cytochrome c oxidase subunit VIIa-L; Short=Cytochrome c oxidase subunit VIIaL; Flags: Precursor;
FUNCTION: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
SUBUNIT: Interacts with PET100.
SUBCELLULAR LOCATION: Mitochondrion inner membrane.
SIMILARITY: Belongs to the cytochrome c oxidase VIIa family.
SEQUENCE CAUTION: Sequence=CAI19899.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: COX7A2
Diseases sorted by gene-association score: barrett's adenocarcinoma (17), esophagus adenocarcinoma (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.5067-0.306 Picture PostScript Text
3' UTR -27.90143-0.195 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003177 - Cyt_c_oxidase_su7a

Pfam Domains:
PF02238 - Cytochrome c oxidase subunit VII

SCOP Domains:
81419 - Mitochondrial cytochrome c oxidase subunit VIIa

ModBase Predicted Comparative 3D Structure on P14406
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004129 cytochrome-c oxidase activity
GO:0009055 electron carrier activity

Biological Process:
GO:0022900 electron transport chain
GO:1902600 hydrogen ion transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  HE647861 - Homo sapiens mRNA for cytochrome c oxidase subunit VIIa polypeptide 2 (COX7A2 gene).
LF384578 - JP 2014500723-A/192081: Polycomb-Associated Non-Coding RNAs.
X15822 - Human COX VIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.).
LF377951 - JP 2014500723-A/185454: Polycomb-Associated Non-Coding RNAs.
BC100852 - Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver), mRNA (cDNA clone MGC:118950 IMAGE:40002220), complete cds.
BC100853 - Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver), mRNA (cDNA clone MGC:118951 IMAGE:40002221), complete cds.
BC100854 - Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver), mRNA (cDNA clone MGC:118952 IMAGE:40002222), complete cds.
BC133654 - Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver), mRNA (cDNA clone MGC:118953 IMAGE:40002224), complete cds.
LF377952 - JP 2014500723-A/185455: Polycomb-Associated Non-Coding RNAs.
BC101826 - Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver), mRNA (cDNA clone MGC:126875 IMAGE:8069332), complete cds.
BC101828 - Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver), mRNA (cDNA clone MGC:126877 IMAGE:8069334), complete cds.
JD095930 - Sequence 76954 from Patent EP1572962.
CR542125 - Homo sapiens full open reading frame cDNA clone RZPDo834C0723D for gene COX7A2, cytochrome c oxidase subunit VIIa polypeptide 2 (liver); complete cds, incl. stopcodon.
AK312154 - Homo sapiens cDNA, FLJ92440, Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2(liver) (COX7A2), mRNA.
KJ901352 - Synthetic construct Homo sapiens clone ccsbBroadEn_10746 COX7A2 gene, encodes complete protein.
KJ904442 - Synthetic construct Homo sapiens clone ccsbBroadEn_13836 COX7A2-like gene, encodes complete protein.
CR407646 - Homo sapiens full open reading frame cDNA clone RZPDo834E0116D for gene COX7A2, cytochrome c oxidase subunit VIIa polypeptide 2 (liver) complete cds, without stopcodon.
LF377953 - JP 2014500723-A/185456: Polycomb-Associated Non-Coding RNAs.
JD345021 - Sequence 326045 from Patent EP1572962.
JD211571 - Sequence 192595 from Patent EP1572962.
LF377958 - JP 2014500723-A/185461: Polycomb-Associated Non-Coding RNAs.
MA620155 - JP 2018138019-A/192081: Polycomb-Associated Non-Coding RNAs.
MA613528 - JP 2018138019-A/185454: Polycomb-Associated Non-Coding RNAs.
MA613529 - JP 2018138019-A/185455: Polycomb-Associated Non-Coding RNAs.
MA613530 - JP 2018138019-A/185456: Polycomb-Associated Non-Coding RNAs.
MA613535 - JP 2018138019-A/185461: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-3781 - aerobic respiration I (cytochrome c)

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5E1, COX7AL, CX7A2_HUMAN, ENST00000684430.1, NR_158784, P14406, Q3MIH5, Q5TF59, Q6FGI2, uc330mwc.1, uc330mwc.2
UCSC ID: ENST00000684430.2_5
RefSeq Accession: NM_001366293.2
Protein: P14406 (aka CX7A2_HUMAN or COXJ_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.