ID:CPSF4_HUMAN DESCRIPTION: RecName: Full=Cleavage and polyadenylation specificity factor subunit 4; AltName: Full=Cleavage and polyadenylation specificity factor 30 kDa subunit; Short=CPSF 30 kDa subunit; AltName: Full=NS1 effector domain-binding protein 1; Short=Neb-1; AltName: Full=No arches homolog; FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). SUBUNIT: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1. Association with influenza A virus NS1 blocks processing of pre-mRNAs, thereby preventing nuclear export of host cell mRNAs. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the CPSF4/YTH1 family. SIMILARITY: Contains 5 C3H1-type zinc fingers. SIMILARITY: Contains 1 CCHC-type zinc finger. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cpsf4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95639
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
JC506674 - Sequence 42 from Patent EP2733220. JC737786 - Sequence 42 from Patent WO2014075939. JC506688 - Sequence 56 from Patent EP2733220. JC737800 - Sequence 56 from Patent WO2014075939. BC050738 - Homo sapiens cleavage and polyadenylation specific factor 4, 30kDa, mRNA (cDNA clone MGC:60384 IMAGE:6199123), complete cds. BC003101 - Homo sapiens cleavage and polyadenylation specific factor 4, 30kDa, mRNA (cDNA clone MGC:1870 IMAGE:3356071), complete cds. U79569 - Human no arches (nar) mRNA, complete cds. AB529148 - Synthetic construct DNA, clone: pF1KB5204, Homo sapiens CPSF4 gene for cleavage and polyadenylation specific factor 4, 30kDa, without stop codon, in Flexi system. CU690790 - Synthetic construct Homo sapiens gateway clone IMAGE:100021318 5' read CPSF4 mRNA. HQ448622 - Synthetic construct Homo sapiens clone IMAGE:100072061; CCSB011823_01 cleavage and polyadenylation specific factor 4, 30kDa (CPSF4) gene, encodes complete protein. KJ893157 - Synthetic construct Homo sapiens clone ccsbBroadEn_02551 CPSF4 gene, encodes complete protein. KJ902171 - Synthetic construct Homo sapiens clone ccsbBroadEn_11565 CPSF4 gene, encodes complete protein. CR542161 - Homo sapiens full open reading frame cDNA clone RZPDo834C0424D for gene CPSF4, cleavage and polyadenylation specific factor 4, 30kDa; complete cds, without stopcodon. AK301745 - Homo sapiens cDNA FLJ52791 complete cds, highly similar to Cleavage and polyadenylation specificityfactor 30 kDa subunit. JD210384 - Sequence 191408 from Patent EP1572962. JD229891 - Sequence 210915 from Patent EP1572962. JD103059 - Sequence 84083 from Patent EP1572962. JD247440 - Sequence 228464 from Patent EP1572962. JD227459 - Sequence 208483 from Patent EP1572962. JD399129 - Sequence 380153 from Patent EP1572962. JD131979 - Sequence 113003 from Patent EP1572962. JD343279 - Sequence 324303 from Patent EP1572962. JD384328 - Sequence 365352 from Patent EP1572962. JD209414 - Sequence 190438 from Patent EP1572962. JD519409 - Sequence 500433 from Patent EP1572962. JD392950 - Sequence 373974 from Patent EP1572962. JD230573 - Sequence 211597 from Patent EP1572962. JD515562 - Sequence 496586 from Patent EP1572962. JD178515 - Sequence 159539 from Patent EP1572962. JD224246 - Sequence 205270 from Patent EP1572962. JD332662 - Sequence 313686 from Patent EP1572962. JD051245 - Sequence 32269 from Patent EP1572962. JD161399 - Sequence 142423 from Patent EP1572962. JD150929 - Sequence 131953 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cpsfPathway - Polyadenylation of mRNA
Reactome (by CSHL, EBI, and GO)
Protein O95639 (Reactome details) participates in the following event(s):
R-HSA-168859 Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) R-HSA-72231 Cleavage and Polyadenylation R-HSA-77589 Recognition of AAUAAA sequence by CPSF R-HSA-72185 mRNA polyadenylation R-HSA-77594 Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA R-HSA-77592 Cleavage of Intronless Pre-mRNA at 3'-end R-HSA-77593 Cleavage and polyadenylation of Intronless Pre-mRNA R-HSA-5696813 TSEN complex cleaves the intron from pre-tRNA R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-156661 Formation of Exon Junction Complex R-HSA-77591 Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex R-HSA-168315 Inhibition of Host mRNA Processing and RNA Silencing R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-77595 Processing of Intronless Pre-mRNAs R-HSA-72187 mRNA 3'-end processing R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-75067 Processing of Capped Intronless Pre-mRNA R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-6784531 tRNA processing in the nucleus R-HSA-168253 Host Interactions with Influenza Factors R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72306 tRNA processing R-HSA-168254 Influenza Infection R-HSA-73857 RNA Polymerase II Transcription R-HSA-5663205 Infectious disease R-HSA-74160 Gene expression (Transcription) R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
