Human Gene CRADD (ENST00000332896.8_4) from GENCODE V47lift37

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Description: CASP2 and RIPK1 domain containing adaptor with death domain, transcript variant 1 (from RefSeq NM_003805.5)
Gencode Transcript: ENST00000332896.8_4
Gencode Gene: ENSG00000169372.13_8
Transcript (Including UTRs)
Position: hg19 chr12:94,071,151-94,244,532 Size: 173,382 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr12:94,072,551-94,244,047 Size: 171,497 Coding Exon Count: 2

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:94,071,151-94,244,532)			mRNA (may differ from genome)		Protein (199 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CRADD Diseases sorted by gene-association score: mental retardation, autosomal recessive 34, with variant lissencephaly* (1230), autosomal recessive non-syndromic intellectual disability* (76), lissencephaly (13), megalencephaly (4) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C006780 bisphenol A C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D015124 8-Bromo Cyclic Adenosine Monophosphate D000082 Acetaminophen D000111 Acetylcysteine D016604 Aflatoxin B1 D001554 Benzene D020111 Chlorodiphenyl (54% Chlorine) more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.87 RPKM in Testis Total median expression: 115.30 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-25.30	104	-0.243	Picture	PostScript	Text
3' UTR	-117.50	485	-0.242	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001315 - CARD
IPR000488 - Death
IPR011029 - DEATH-like

Pfam Domains:
PF00531 - Death domain
PF00619 - Caspase recruitment domain

SCOP Domains:
47986 - DEATH domain

ModBase Predicted Comparative 3D Structure on Q53XL1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0002020 protease binding GO:0070513 death domain binding Biological Process: GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007165 signal transduction GO:0042981 regulation of apoptotic process GO:2001235 positive regulation of apoptotic signaling pathway Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AK296225 - Homo sapiens cDNA FLJ59911 complete cds, moderately similar to Death domain-containing protein CRADD. AK294986 - Homo sapiens cDNA FLJ50762 complete cds, highly similar to Death domain-containing protein CRADD. AK314861 - Homo sapiens cDNA, FLJ95760, Homo sapiens CASP2 and RIPK1 domain containing adaptor with deathdomain (CRADD), mRNA. U79115 - Human death adaptor molecule RAIDD (RAIDD) mRNA, complete cds. BC017042 - Homo sapiens CASP2 and RIPK1 domain containing adaptor with death domain, mRNA (cDNA clone MGC:9163 IMAGE:3849848), complete cds. U84388 - Human death domain containing protein CRADD mRNA, complete cds. BC037905 - Homo sapiens CASP2 and RIPK1 domain containing adaptor with death domain, mRNA (cDNA clone MGC:43958 IMAGE:5276510), complete cds. AB451412 - Homo sapiens CRADD mRNA for CASP2 and RIPK1 domain containing adaptor with death domain, partial cds, clone: FLJ08117AAAF. AB590262 - Synthetic construct DNA, clone: pFN21AE1411, Homo sapiens CRADD gene for CASP2 and RIPK1 domain containing adaptor with death domain, without stop codon, in Flexi system. CR407643 - Homo sapiens full open reading frame cDNA clone RZPDo834F122D for gene CRADD, CASP2 and RIPK1 domain containing adaptor with death domain complete cds, without stopcodon. AB451280 - Homo sapiens CRADD mRNA for CASP2 and RIPK1 domain containing adaptor with death domain, complete cds, clone: FLJ08117AAAN. BT009837 - Homo sapiens CASP2 and RIPK1 domain containing adaptor with death domain mRNA, complete cds. DQ891780 - Synthetic construct clone IMAGE:100004410; FLH179856.01X; RZPDo839D04132D CASP2 and RIPK1 domain containing adaptor with death domain (CRADD) gene, encodes complete protein. DQ894964 - Synthetic construct Homo sapiens clone IMAGE:100009424; FLH179852.01L; RZPDo839D04131D CASP2 and RIPK1 domain containing adaptor with death domain (CRADD) gene, encodes complete protein. KJ905972 - Synthetic construct Homo sapiens clone ccsbBroadEn_15642 CRADD gene, encodes complete protein. CU691520 - Synthetic construct Homo sapiens gateway clone IMAGE:100020817 5' read CRADD mRNA. LF208868 - JP 2014500723-A/16371: Polycomb-Associated Non-Coding RNAs. JD316146 - Sequence 297170 from Patent EP1572962. JD292811 - Sequence 273835 from Patent EP1572962. JD279670 - Sequence 260694 from Patent EP1572962. LF323568 - JP 2014500723-A/131071: Polycomb-Associated Non-Coding RNAs. KY966269 - Homo sapiens cell line 95T1000 CRADD/LYZ fusion mRNA, partial sequence. LF323567 - JP 2014500723-A/131070: Polycomb-Associated Non-Coding RNAs. MA559145 - JP 2018138019-A/131071: Polycomb-Associated Non-Coding RNAs. MA559144 - JP 2018138019-A/131070: Polycomb-Associated Non-Coding RNAs. MA444445 - JP 2018138019-A/16371: Polycomb-Associated Non-Coding RNAs. JD271747 - Sequence 252771 from Patent EP1572962. JD134597 - Sequence 115621 from Patent EP1572962. JD506543 - Sequence 487567 from Patent EP1572962. JD550533 - Sequence 531557 from Patent EP1572962. JD303698 - Sequence 284722 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: CRADD , ENST00000332896.1, ENST00000332896.2, ENST00000332896.3, ENST00000332896.4, ENST00000332896.5, ENST00000332896.6, ENST00000332896.7, hCG_40089 , NM_003805, Q53XL1, Q53XL1_HUMAN, uc317toa.1, uc317toa.2 UCSC ID: ENST00000332896.8_4 RefSeq Accession: NM_003805.5 Protein: Q53XL1

Gene Model Information


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Methods, Credits, and Use Restrictions


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