Human Gene CRAMP1 (ENST00000293925.9_2) from GENCODE V47lift37
  Description: Nucleus (from UniProt Q96RY5)
Gencode Transcript: ENST00000293925.9_2
Gencode Gene: ENSG00000007545.16_9
Transcript (Including UTRs)
   Position: hg19 chr16:1,664,641-1,727,907 Size: 63,267 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr16:1,664,641-1,724,046 Size: 59,406 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:1,664,641-1,727,907)mRNA (may differ from genome)Protein (1269 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: CRML_HUMAN
DESCRIPTION: RecName: Full=Protein cramped-like; AltName: Full=Hematological and neurological expressed 1-like protein;
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the cramped family.
SIMILARITY: Contains 1 SANT domain.
SEQUENCE CAUTION: Sequence=AAK61288.1; Type=Erroneous gene model prediction; Sequence=CAD38692.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.07 RPKM in Testis
Total median expression: 51.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -1384.203861-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001005 - SANT/Myb
IPR017884 - SANT_dom

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q96RY5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC137172 - Homo sapiens Crm, cramped-like (Drosophila), mRNA (cDNA clone MGC:168792 IMAGE:9021169), complete cds.
BC137173 - Homo sapiens Crm, cramped-like (Drosophila), mRNA (cDNA clone MGC:168793 IMAGE:9021170), complete cds.
AL833832 - Homo sapiens mRNA; cDNA DKFZp434O1216 (from clone DKFZp434O1216).
AB037847 - Homo sapiens mRNA for KIAA1426 protein, partial cds.
BC152477 - Homo sapiens Crm, cramped-like (Drosophila), mRNA (cDNA clone MGC:176736 IMAGE:8862615), complete cds.
AB385466 - Synthetic construct DNA, clone: pF1KA1426, Homo sapiens HN1L gene for cramped-like protein, complete cds, without stop codon, in Flexi system.
KJ902975 - Synthetic construct Homo sapiens clone ccsbBroadEn_12369 CRAMP1L gene, encodes complete protein.
JD095912 - Sequence 76936 from Patent EP1572962.
JD467285 - Sequence 448309 from Patent EP1572962.
JD065212 - Sequence 46236 from Patent EP1572962.
JD337146 - Sequence 318170 from Patent EP1572962.
JD522063 - Sequence 503087 from Patent EP1572962.
JD045913 - Sequence 26937 from Patent EP1572962.
JD488076 - Sequence 469100 from Patent EP1572962.
JD148394 - Sequence 129418 from Patent EP1572962.
AK095591 - Homo sapiens cDNA FLJ38272 fis, clone FCBBF3002818.
JD507673 - Sequence 488697 from Patent EP1572962.
JD065082 - Sequence 46106 from Patent EP1572962.
JD425670 - Sequence 406694 from Patent EP1572962.
JD447897 - Sequence 428921 from Patent EP1572962.
JD120218 - Sequence 101242 from Patent EP1572962.
JD273674 - Sequence 254698 from Patent EP1572962.
JD408338 - Sequence 389362 from Patent EP1572962.
JD249738 - Sequence 230762 from Patent EP1572962.
JD216781 - Sequence 197805 from Patent EP1572962.
JD563898 - Sequence 544922 from Patent EP1572962.
JD328866 - Sequence 309890 from Patent EP1572962.
JD402527 - Sequence 383551 from Patent EP1572962.
JD258117 - Sequence 239141 from Patent EP1572962.
JD325298 - Sequence 306322 from Patent EP1572962.
JD174887 - Sequence 155911 from Patent EP1572962.
JD265807 - Sequence 246831 from Patent EP1572962.
DQ573037 - Homo sapiens piRNA piR-41149, complete sequence.
JD057685 - Sequence 38709 from Patent EP1572962.
JD142202 - Sequence 123226 from Patent EP1572962.
AK056087 - Homo sapiens cDNA FLJ31525 fis, clone NT2RI2000294.
JD271265 - Sequence 252289 from Patent EP1572962.
JD458307 - Sequence 439331 from Patent EP1572962.
JD376868 - Sequence 357892 from Patent EP1572962.
JD416875 - Sequence 397899 from Patent EP1572962.
JD539849 - Sequence 520873 from Patent EP1572962.
JD397510 - Sequence 378534 from Patent EP1572962.
JD401081 - Sequence 382105 from Patent EP1572962.
JD276248 - Sequence 257272 from Patent EP1572962.
JD149036 - Sequence 130060 from Patent EP1572962.
JD313866 - Sequence 294890 from Patent EP1572962.
JD263295 - Sequence 244319 from Patent EP1572962.
JD328972 - Sequence 309996 from Patent EP1572962.
JD425033 - Sequence 406057 from Patent EP1572962.
JD173735 - Sequence 154759 from Patent EP1572962.
JD101577 - Sequence 82601 from Patent EP1572962.
JD044390 - Sequence 25414 from Patent EP1572962.
JD448639 - Sequence 429663 from Patent EP1572962.
JD067873 - Sequence 48897 from Patent EP1572962.
JD467458 - Sequence 448482 from Patent EP1572962.
JD295142 - Sequence 276166 from Patent EP1572962.
JD498638 - Sequence 479662 from Patent EP1572962.
JD250696 - Sequence 231720 from Patent EP1572962.
JD261578 - Sequence 242602 from Patent EP1572962.
JD046460 - Sequence 27484 from Patent EP1572962.
JD195111 - Sequence 176135 from Patent EP1572962.
JD429350 - Sequence 410374 from Patent EP1572962.
JD231727 - Sequence 212751 from Patent EP1572962.
JD487421 - Sequence 468445 from Patent EP1572962.
JD518562 - Sequence 499586 from Patent EP1572962.
JD518674 - Sequence 499698 from Patent EP1572962.
JD445019 - Sequence 426043 from Patent EP1572962.
JD402994 - Sequence 384018 from Patent EP1572962.
JD328984 - Sequence 310008 from Patent EP1572962.
JD365995 - Sequence 347019 from Patent EP1572962.
JD548163 - Sequence 529187 from Patent EP1572962.
JD258490 - Sequence 239514 from Patent EP1572962.
JD144593 - Sequence 125617 from Patent EP1572962.
JD455012 - Sequence 436036 from Patent EP1572962.
JD122433 - Sequence 103457 from Patent EP1572962.
JD047693 - Sequence 28717 from Patent EP1572962.
JD446255 - Sequence 427279 from Patent EP1572962.
JD430407 - Sequence 411431 from Patent EP1572962.
JD529591 - Sequence 510615 from Patent EP1572962.
JD170020 - Sequence 151044 from Patent EP1572962.
JD306767 - Sequence 287791 from Patent EP1572962.
JD321560 - Sequence 302584 from Patent EP1572962.
JD447276 - Sequence 428300 from Patent EP1572962.
JD138298 - Sequence 119322 from Patent EP1572962.
JD175906 - Sequence 156930 from Patent EP1572962.
JD332339 - Sequence 313363 from Patent EP1572962.
JD448323 - Sequence 429347 from Patent EP1572962.
JD351726 - Sequence 332750 from Patent EP1572962.
JD523404 - Sequence 504428 from Patent EP1572962.
JD406739 - Sequence 387763 from Patent EP1572962.
JD461401 - Sequence 442425 from Patent EP1572962.
JD405408 - Sequence 386432 from Patent EP1572962.
JD229462 - Sequence 210486 from Patent EP1572962.
JD218971 - Sequence 199995 from Patent EP1572962.
JD484007 - Sequence 465031 from Patent EP1572962.
JD335246 - Sequence 316270 from Patent EP1572962.
JD393201 - Sequence 374225 from Patent EP1572962.
JD406782 - Sequence 387806 from Patent EP1572962.
JD089912 - Sequence 70936 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MZL1, AB037847, B1AJY1, C16orf34, CRAMP1 , CRAMP1L, CRML_HUMAN, ENST00000293925.1, ENST00000293925.2, ENST00000293925.3, ENST00000293925.4, ENST00000293925.5, ENST00000293925.6, ENST00000293925.7, ENST00000293925.8, HN1L, KIAA1426, Q8NDN1, Q96RY5, Q9P2C1, uc317lfm.1, uc317lfm.2
UCSC ID: ENST00000293925.9_2
RefSeq Accession: NM_020825.4
Protein: Q96RY5 (aka CRML_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.