Human Gene CREB1 (ENST00000353267.8_7) from GENCODE V47lift37
  Description: cAMP responsive element binding protein 1, transcript variant 9 (from RefSeq NR_163947.1)
Gencode Transcript: ENST00000353267.8_7
Gencode Gene: ENSG00000118260.15_16
Transcript (Including UTRs)
   Position: hg19 chr2:208,394,686-208,470,712 Size: 76,027 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr2:208,420,360-208,461,782 Size: 41,423 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:208,394,686-208,470,712)mRNA (may differ from genome)Protein (327 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CREB1
Diseases sorted by gene-association score: histiocytoma, angiomatoid fibrous, somatic* (500), melanoma of soft tissue* (247), diabetic encephalopathy (21), fibrous histiocytoma (18), drug addiction (16), coffin-lowry syndrome (16), histiocytoma (15), opiate dependence (13), charcot-marie-tooth disease, type 4c (13), clear cell sarcoma (12), human t-cell leukemia virus type 1 (11), rett syndrome (10), huntington disease (10), t-cell leukemia (9), mood disorder (9), chromosome 16p13.3 deletion syndrome, proximal (8), human t-cell leukemia virus type 2 (6), bipolar disorder (5), hypoxia (5), acrodysostosis (5), amnestic disorder (5), lung sarcoma (5), arrhythmogenic right ventricular dysplasia 1 (4), dyschromatosis universalis hereditaria (4), cerebral hypoxia (4), spinocerebellar ataxia 12 (4), pheochromocytoma (2), prostate cancer (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.15 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 215.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.50181-0.351 Picture PostScript Text
3' UTR -2194.508930-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR003102 - Coactivator_CBP_pKID
IPR001630 - Leuzip_CREB

Pfam Domains:
PF00170 - bZIP transcription factor
PF02173 - pKID domain
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain

ModBase Predicted Comparative 3D Structure on Q53X93
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  AK312747 - Homo sapiens cDNA, FLJ93156, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant B, mRNA.
LF205222 - JP 2014500723-A/12725: Polycomb-Associated Non-Coding RNAs.
LF213835 - JP 2014500723-A/21338: Polycomb-Associated Non-Coding RNAs.
BC095407 - Homo sapiens cAMP responsive element binding protein 1, mRNA (cDNA clone MGC:110900 IMAGE:30344522), complete cds.
X55545 - Homo sapiens mRNA for CREB protein.
M27691 - Human transactivator protein (CREB) mRNA, complete cds.
BC010636 - Homo sapiens cAMP responsive element binding protein 1, mRNA (cDNA clone MGC:9284 IMAGE:3872792), complete cds.
AK298740 - Homo sapiens cDNA FLJ56700 complete cds, highly similar to cAMP response element-binding protein.
AY347527 - Homo sapiens CREB mRNA, complete cds.
AK315226 - Homo sapiens cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA.
MA440799 - JP 2018138019-A/12725: Polycomb-Associated Non-Coding RNAs.
MA449412 - JP 2018138019-A/21338: Polycomb-Associated Non-Coding RNAs.
JD136829 - Sequence 117853 from Patent EP1572962.
JD180853 - Sequence 161877 from Patent EP1572962.
LF212826 - JP 2014500723-A/20329: Polycomb-Associated Non-Coding RNAs.
JD240487 - Sequence 221511 from Patent EP1572962.
LF318185 - JP 2014500723-A/125688: Polycomb-Associated Non-Coding RNAs.
MA448403 - JP 2018138019-A/20329: Polycomb-Associated Non-Coding RNAs.
MA553762 - JP 2018138019-A/125688: Polycomb-Associated Non-Coding RNAs.
CU679771 - Synthetic construct Homo sapiens gateway clone IMAGE:100019015 5' read CREB1 mRNA.
AB385549 - Synthetic construct DNA, clone: pF1KB5414, Homo sapiens CREB1 gene for cAMP response element-binding protein, complete cds, without stop codon, in Flexi system.
CR407617 - Homo sapiens full open reading frame cDNA clone RZPDo834B062D for gene CREB1, cAMP responsive element binding protein 1 complete cds, without stopcodon.
DQ894336 - Synthetic construct Homo sapiens clone IMAGE:100008796; FLH169826.01L; RZPDo839G0895D cAMP responsive element binding protein 1 (CREB1) gene, encodes complete protein.
BT019509 - Homo sapiens cAMP responsive element binding protein 1 mRNA, complete cds.
DQ891157 - Synthetic construct clone IMAGE:100003787; FLH169830.01X; RZPDo839G0896D cAMP responsive element binding protein 1 (CREB1) gene, encodes complete protein.
KJ890966 - Synthetic construct Homo sapiens clone ccsbBroadEn_00360 CREB1 gene, encodes complete protein.
M34356 - Human active transcription factor CREB mRNA, complete cds.
X60003 - Human delta CREB mRNA for cAMP-responsive element (CRE) binding protein.
LF318199 - JP 2014500723-A/125702: Polycomb-Associated Non-Coding RNAs.
AK302333 - Homo sapiens cDNA FLJ57667 complete cds, highly similar to cAMP response element-binding protein.
LF318200 - JP 2014500723-A/125703: Polycomb-Associated Non-Coding RNAs.
S78693 - alpha CREB-1=cyclic AMP response element-binding protein-1 alpha isoform {alternatively spliced, internal fragment} [human, placenta, mRNA Partial, 64 nt].
S78695 - alpha beta CREB-1=cyclic AMP response element-binding protein-1 alpha beta isoform {alternatively spliced, internal fragment} [human, placenta, mRNA Partial, 81 nt].
JD286222 - Sequence 267246 from Patent EP1572962.
JD297313 - Sequence 278337 from Patent EP1572962.
LF318204 - JP 2014500723-A/125707: Polycomb-Associated Non-Coding RNAs.
JD429537 - Sequence 410561 from Patent EP1572962.
LF318205 - JP 2014500723-A/125708: Polycomb-Associated Non-Coding RNAs.
JD183919 - Sequence 164943 from Patent EP1572962.
JD334025 - Sequence 315049 from Patent EP1572962.
JD528338 - Sequence 509362 from Patent EP1572962.
JD562697 - Sequence 543721 from Patent EP1572962.
JD093428 - Sequence 74452 from Patent EP1572962.
LF318206 - JP 2014500723-A/125709: Polycomb-Associated Non-Coding RNAs.
JD235366 - Sequence 216390 from Patent EP1572962.
JD160403 - Sequence 141427 from Patent EP1572962.
JD561872 - Sequence 542896 from Patent EP1572962.
JD148622 - Sequence 129646 from Patent EP1572962.
JD179378 - Sequence 160402 from Patent EP1572962.
JD381259 - Sequence 362283 from Patent EP1572962.
JD044023 - Sequence 25047 from Patent EP1572962.
JD482036 - Sequence 463060 from Patent EP1572962.
JD499659 - Sequence 480683 from Patent EP1572962.
JD286713 - Sequence 267737 from Patent EP1572962.
JD511545 - Sequence 492569 from Patent EP1572962.
JD319539 - Sequence 300563 from Patent EP1572962.
JD319540 - Sequence 300564 from Patent EP1572962.
JD105752 - Sequence 86776 from Patent EP1572962.
JD071050 - Sequence 52074 from Patent EP1572962.
JD119120 - Sequence 100144 from Patent EP1572962.
JD278366 - Sequence 259390 from Patent EP1572962.
JD144694 - Sequence 125718 from Patent EP1572962.
JD085874 - Sequence 66898 from Patent EP1572962.
JD337206 - Sequence 318230 from Patent EP1572962.
JD205971 - Sequence 186995 from Patent EP1572962.
JD344625 - Sequence 325649 from Patent EP1572962.
JD443377 - Sequence 424401 from Patent EP1572962.
AK126342 - Homo sapiens cDNA FLJ44370 fis, clone TRACH3008902.
LF318207 - JP 2014500723-A/125710: Polycomb-Associated Non-Coding RNAs.
AK123952 - Homo sapiens cDNA FLJ41958 fis, clone PUAEN2001345.
LF318208 - JP 2014500723-A/125711: Polycomb-Associated Non-Coding RNAs.
LF318210 - JP 2014500723-A/125713: Polycomb-Associated Non-Coding RNAs.
LF318211 - JP 2014500723-A/125714: Polycomb-Associated Non-Coding RNAs.
AK091534 - Homo sapiens cDNA FLJ34215 fis, clone FCBBF3021985.
LF318212 - JP 2014500723-A/125715: Polycomb-Associated Non-Coding RNAs.
AK095116 - Homo sapiens cDNA FLJ37797 fis, clone BRSSN1000153.
MA553776 - JP 2018138019-A/125702: Polycomb-Associated Non-Coding RNAs.
MA553777 - JP 2018138019-A/125703: Polycomb-Associated Non-Coding RNAs.
MA553781 - JP 2018138019-A/125707: Polycomb-Associated Non-Coding RNAs.
MA553782 - JP 2018138019-A/125708: Polycomb-Associated Non-Coding RNAs.
MA553783 - JP 2018138019-A/125709: Polycomb-Associated Non-Coding RNAs.
MA553784 - JP 2018138019-A/125710: Polycomb-Associated Non-Coding RNAs.
MA553785 - JP 2018138019-A/125711: Polycomb-Associated Non-Coding RNAs.
MA553787 - JP 2018138019-A/125713: Polycomb-Associated Non-Coding RNAs.
MA553788 - JP 2018138019-A/125714: Polycomb-Associated Non-Coding RNAs.
MA553789 - JP 2018138019-A/125715: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1
h_hifPathway - Hypoxia-Inducible Factor in the Cardiovascular System
h_melanocytepathway - Melanocyte Development and Pigmentation Pathway
h_crebPathway - Transcription factor CREB and its extracellular signals
h_CaCaMPathway - Ca++/ Calmodulin-dependent Protein Kinase Activation
h_HuntingtonPathway - Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors
h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM
h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus
h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways
h_mapkPathway - MAPKinase Signaling Pathway
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R437, CREB1 , ENST00000353267.1, ENST00000353267.2, ENST00000353267.3, ENST00000353267.4, ENST00000353267.5, ENST00000353267.6, ENST00000353267.7, hCG_15208 , NR_163947, Q53X93, Q53X93_HUMAN, uc317yjg.1, uc317yjg.2
UCSC ID: ENST00000353267.8_7
RefSeq Accession: NM_004379.5
Protein: Q53X93

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.