Human Gene CREB5 (ENST00000357727.7_7) from GENCODE V47lift37
  Description: cAMP responsive element binding protein 5, transcript variant 1 (from RefSeq NM_182898.4)
Gencode Transcript: ENST00000357727.7_7
Gencode Gene: ENSG00000146592.17_11
Transcript (Including UTRs)
   Position: hg19 chr7:28,452,137-28,865,511 Size: 413,375 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr7:28,452,534-28,858,896 Size: 406,363 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:28,452,137-28,865,511)mRNA (may differ from genome)Protein (508 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CREB5_HUMAN
DESCRIPTION: RecName: Full=Cyclic AMP-responsive element-binding protein 5; Short=CREB-5; Short=cAMP-responsive element-binding protein 5; AltName: Full=CRE-BPa;
FUNCTION: Binds to the cAMP response element and activates transcription.
SUBUNIT: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the bZIP family.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
SIMILARITY: Contains 1 C2H2-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CREB5
Diseases sorted by gene-association score: ascariasis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.08 RPKM in Whole Blood
Total median expression: 93.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.80397-0.236 Picture PostScript Text
3' UTR -1599.306615-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR016378 - TF_cAMP-dep
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00170 - bZIP transcription factor
PF03131 - bZIP Maf transcription factor
PF07716 - Basic region leucine zipper

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
57959 - Leucine zipper domain

ModBase Predicted Comparative 3D Structure on Q02930
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  L05913 - Human cAMP responsive element binding protein gamma subunit (CREBPA) mRNA, complete cds.
L05515 - Homo sapiens cAMP response element-binding protein (CRE-BP1) mRNA, complete cds.
L05911 - Human cAMP responsive element binding protein beta subunit (CREBPA) mRNA, complete cds.
AB451409 - Homo sapiens CREB5 mRNA for cAMP responsive element binding protein 5 isoform alpha, partial cds, clone: FLJ08114AAAF.
AK292916 - Homo sapiens cDNA FLJ75156 complete cds, highly similar to Homo sapiens cAMP responsive element binding protein 5 (CREB5),mRNA.
L05912 - Human cAMP responsive element binding protein delta subunit (CREBPA) mRNA, complete cds.
AK300455 - Homo sapiens cDNA FLJ50677 complete cds, highly similar to cAMP response element-binding protein 5.
BC059400 - Homo sapiens cAMP responsive element binding protein 5, mRNA (cDNA clone MGC:71757 IMAGE:30343999), complete cds.
AK316187 - Homo sapiens cDNA, FLJ79086 complete cds, highly similar to cAMP response element-binding protein 5.
AB209262 - Homo sapiens mRNA for cAMP responsive element binding protein 5 isoform beta variant protein.
KJ901999 - Synthetic construct Homo sapiens clone ccsbBroadEn_11393 CREB5 gene, encodes complete protein.
CU687374 - Synthetic construct Homo sapiens gateway clone IMAGE:100021142 5' read CREB5 mRNA.
AK298121 - Homo sapiens cDNA FLJ50598 complete cds, highly similar to Homo sapiens cAMP responsive element binding protein 5 (CREB5), transcript variant 4, mRNA.
EF491798 - Homo sapiens clone CREB5 mRNA, partial sequence; alternatively spliced.
JD434492 - Sequence 415516 from Patent EP1572962.
JD089697 - Sequence 70721 from Patent EP1572962.
JD447779 - Sequence 428803 from Patent EP1572962.
JD550159 - Sequence 531183 from Patent EP1572962.
JD318709 - Sequence 299733 from Patent EP1572962.
JD177321 - Sequence 158345 from Patent EP1572962.
JD259813 - Sequence 240837 from Patent EP1572962.
JD150679 - Sequence 131703 from Patent EP1572962.
JD456812 - Sequence 437836 from Patent EP1572962.
JD456813 - Sequence 437837 from Patent EP1572962.
JD412071 - Sequence 393095 from Patent EP1572962.
JD240595 - Sequence 221619 from Patent EP1572962.
JD516125 - Sequence 497149 from Patent EP1572962.
JD053297 - Sequence 34321 from Patent EP1572962.
JD511916 - Sequence 492940 from Patent EP1572962.
JD036392 - Sequence 17416 from Patent EP1572962.
JD303541 - Sequence 284565 from Patent EP1572962.
JD468022 - Sequence 449046 from Patent EP1572962.
JD163100 - Sequence 144124 from Patent EP1572962.
JD288398 - Sequence 269422 from Patent EP1572962.
AK057151 - Homo sapiens cDNA FLJ32589 fis, clone SPLEN2000443.
JD123259 - Sequence 104283 from Patent EP1572962.
JD416850 - Sequence 397874 from Patent EP1572962.
JD391520 - Sequence 372544 from Patent EP1572962.
JD154451 - Sequence 135475 from Patent EP1572962.
JD154019 - Sequence 135043 from Patent EP1572962.
JD323303 - Sequence 304327 from Patent EP1572962.
JD459603 - Sequence 440627 from Patent EP1572962.
JD045827 - Sequence 26851 from Patent EP1572962.
JD437600 - Sequence 418624 from Patent EP1572962.
JD429736 - Sequence 410760 from Patent EP1572962.
JD113129 - Sequence 94153 from Patent EP1572962.
JD171264 - Sequence 152288 from Patent EP1572962.
JD235080 - Sequence 216104 from Patent EP1572962.
JD404252 - Sequence 385276 from Patent EP1572962.
JD312682 - Sequence 293706 from Patent EP1572962.
JD538528 - Sequence 519552 from Patent EP1572962.
JD440185 - Sequence 421209 from Patent EP1572962.
JD236115 - Sequence 217139 from Patent EP1572962.
JD313570 - Sequence 294594 from Patent EP1572962.
JD359079 - Sequence 340103 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA51, B4DU13, B5BUH3, C9JK47, CREB5_HUMAN, CREBPA, ENST00000357727.1, ENST00000357727.2, ENST00000357727.3, ENST00000357727.4, ENST00000357727.5, ENST00000357727.6, NM_182898, Q02930, Q05886, Q06246, Q75N02, Q86UJ9, uc318aew.1, uc318aew.2
UCSC ID: ENST00000357727.7_7
RefSeq Accession: NM_182898.4
Protein: Q02930 (aka CREB5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.