Human Gene CREG1 (ENST00000370509.5_11) from GENCODE V47lift37
  Description: cellular repressor of E1A stimulated genes 1 (from RefSeq NM_003851.3)
Gencode Transcript: ENST00000370509.5_11
Gencode Gene: ENSG00000143162.9_14
Transcript (Including UTRs)
   Position: hg19 chr1:167,510,250-167,522,999 Size: 12,750 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:167,511,535-167,522,978 Size: 11,444 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:167,510,250-167,522,999)mRNA (may differ from genome)Protein (220 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CREG1_HUMAN
DESCRIPTION: RecName: Full=Protein CREG1; AltName: Full=Cellular repressor of E1A-stimulated genes 1; Flags: Precursor;
FUNCTION: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
SUBUNIT: Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.
SUBCELLULAR LOCATION: Secreted.
PTM: N-glycosylated.
SIMILARITY: Belongs to the CREG family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 79.52 RPKM in Adrenal Gland
Total median expression: 1877.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.0021-0.143 Picture PostScript Text
3' UTR -292.371285-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014631 - CREG
IPR012349 - Split_barrel_FMN-bd
IPR009002 - Split_barrel_FMN-bd-related

Pfam Domains:
PF13883 - Pyridoxamine 5'-phosphate oxidase

SCOP Domains:
50475 - FMN-binding split barrel

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1XHN - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O75629
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0048037 cofactor binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0008283 cell proliferation
GO:0040008 regulation of growth
GO:0043312 neutrophil degranulation
GO:1903507 negative regulation of nucleic acid-templated transcription

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005667 transcription factor complex
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF205433 - JP 2014500723-A/12936: Polycomb-Associated Non-Coding RNAs.
BC006786 - Homo sapiens cellular repressor of E1A-stimulated genes 1, mRNA (cDNA clone MGC:5274 IMAGE:2900817), complete cds.
BC008628 - Homo sapiens cellular repressor of E1A-stimulated genes 1, mRNA (cDNA clone MGC:17147 IMAGE:4339480), complete cds.
AK095456 - Homo sapiens cDNA FLJ38137 fis, clone D9OST2001433, highly similar to Homo sapiens cellular repressor of E1A-stimulated genes CREG mRNA.
LF213843 - JP 2014500723-A/21346: Polycomb-Associated Non-Coding RNAs.
AF084523 - Homo sapiens cellular repressor of E1A-stimulated genes CREG mRNA, complete cds.
AK130006 - Homo sapiens cDNA FLJ26496 fis, clone KDN06443, highly similar to Homo sapiens cellular repressor of E1A-stimulated genes (CREG).
AK075375 - Homo sapiens cDNA PSEC0065 fis, clone NT2RP2000997, highly similar to Protein CREG1 precursor.
JD326772 - Sequence 307796 from Patent EP1572962.
JD204259 - Sequence 185283 from Patent EP1572962.
JD311402 - Sequence 292426 from Patent EP1572962.
JD047151 - Sequence 28175 from Patent EP1572962.
JD091122 - Sequence 72146 from Patent EP1572962.
JD486999 - Sequence 468023 from Patent EP1572962.
JD049973 - Sequence 30997 from Patent EP1572962.
JD511371 - Sequence 492395 from Patent EP1572962.
JD555426 - Sequence 536450 from Patent EP1572962.
JD253531 - Sequence 234555 from Patent EP1572962.
JD360246 - Sequence 341270 from Patent EP1572962.
JD246152 - Sequence 227176 from Patent EP1572962.
JD357452 - Sequence 338476 from Patent EP1572962.
JD332995 - Sequence 314019 from Patent EP1572962.
JD182058 - Sequence 163082 from Patent EP1572962.
JD074276 - Sequence 55300 from Patent EP1572962.
JD115066 - Sequence 96090 from Patent EP1572962.
JD324220 - Sequence 305244 from Patent EP1572962.
JD229789 - Sequence 210813 from Patent EP1572962.
JD381754 - Sequence 362778 from Patent EP1572962.
LF320461 - JP 2014500723-A/127964: Polycomb-Associated Non-Coding RNAs.
JD493733 - Sequence 474757 from Patent EP1572962.
LF320460 - JP 2014500723-A/127963: Polycomb-Associated Non-Coding RNAs.
JD549598 - Sequence 530622 from Patent EP1572962.
JD362990 - Sequence 344014 from Patent EP1572962.
JD114356 - Sequence 95380 from Patent EP1572962.
JD563161 - Sequence 544185 from Patent EP1572962.
JD513187 - Sequence 494211 from Patent EP1572962.
AY359071 - Homo sapiens clone DNA71269 CREG (UNQ727) mRNA, complete cds.
JD539042 - Sequence 520066 from Patent EP1572962.
LF320459 - JP 2014500723-A/127962: Polycomb-Associated Non-Coding RNAs.
JD061262 - Sequence 42286 from Patent EP1572962.
JD068063 - Sequence 49087 from Patent EP1572962.
DQ891131 - Synthetic construct clone IMAGE:100003761; FLH169589.01X; RZPDo839D1296D cellular repressor of E1A-stimulated genes 1 (CREG1) gene, encodes complete protein.
DQ894310 - Synthetic construct Homo sapiens clone IMAGE:100008770; FLH169585.01L; RZPDo839D1295D cellular repressor of E1A-stimulated genes 1 (CREG1) gene, encodes complete protein.
AK315497 - Homo sapiens cDNA, FLJ96560, Homo sapiens cellular repressor of E1A-stimulated genes (CREG),mRNA.
AB463481 - Synthetic construct DNA, clone: pF1KB8119, Homo sapiens CREG1 gene for cellular repressor of E1A-stimulated genes 1, without stop codon, in Flexi system.
LF320457 - JP 2014500723-A/127960: Polycomb-Associated Non-Coding RNAs.
LF211766 - JP 2014500723-A/19269: Polycomb-Associated Non-Coding RNAs.
JD261375 - Sequence 242399 from Patent EP1572962.
MA441010 - JP 2018138019-A/12936: Polycomb-Associated Non-Coding RNAs.
MA449420 - JP 2018138019-A/21346: Polycomb-Associated Non-Coding RNAs.
MA556038 - JP 2018138019-A/127964: Polycomb-Associated Non-Coding RNAs.
MA556037 - JP 2018138019-A/127963: Polycomb-Associated Non-Coding RNAs.
MA556036 - JP 2018138019-A/127962: Polycomb-Associated Non-Coding RNAs.
MA556034 - JP 2018138019-A/127960: Polycomb-Associated Non-Coding RNAs.
MA447343 - JP 2018138019-A/19269: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75629 (Reactome details) participates in the following event(s):

R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDD4, CREG, CREG1_HUMAN, ENST00000370509.1, ENST00000370509.2, ENST00000370509.3, ENST00000370509.4, NM_003851, O75629, Q8N9A3, uc318ilb.1, uc318ilb.2, UNQ727/PRO1409
UCSC ID: ENST00000370509.5_11
RefSeq Accession: NM_003851.3
Protein: O75629 (aka CREG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.