Human Gene CRH (ENST00000276571.5_7) from GENCODE V47lift37
  Description: corticotropin releasing hormone (from RefSeq NM_000756.4)
Gencode Transcript: ENST00000276571.5_7
Gencode Gene: ENSG00000147571.5_9
Transcript (Including UTRs)
   Position: hg19 chr8:67,088,611-67,090,699 Size: 2,089 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr8:67,089,122-67,089,712 Size: 591 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:67,088,611-67,090,699)mRNA (may differ from genome)Protein (196 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CRF_HUMAN
DESCRIPTION: RecName: Full=Corticoliberin; AltName: Full=Corticotropin-releasing factor; Short=CRF; AltName: Full=Corticotropin-releasing hormone; Flags: Precursor;
FUNCTION: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.
SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).
INTERACTION: P34998:CRHR1; NbExp=2; IntAct=EBI-3870390, EBI-3870393;
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
WEB RESOURCE: Name=Wikipedia; Note=Corticotropin-releasing hormone entry; URL="http://en.wikipedia.org/wiki/Corticotropin-releasing_hormone";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CRH
Diseases sorted by gene-association score: crh-related related nocturnal frontal lobe epilepsy, autosomal dominant* (100), autosomal dominant nocturnal frontal lobe epilepsy* (74), post-traumatic stress disorder (33), postpartum depression (28), adrenal carcinoma (28), acth deficiency (26), cushing's syndrome (25), melancholia (23), hypothalamic disease (23), adrenal gland hyperfunction (21), endogenous depression (20), chronic fatigue syndrome (16), hypoadrenalism (16), mood disorder (15), adrenal cortex disease (14), adrenal gland disease (14), panic disorder (12), nelson syndrome (11), anorexia nervosa (11), atypical depressive disorder (11), pituitary adenoma, acth-secreting (11), irritable bowel syndrome (11), pituitary carcinoma (10), adrenal adenoma (10), pituitary-dependent cushing's disease (10), hypoglycemia (10), addison's disease (10), pituitary adenoma (9), sheehan syndrome (8), major depressive disorder and accelerated response to antidepressant drug treatment (8), adrenal cortical hypofunction (8), hypopituitarism (8), gonadal disease (8), olivopontocerebellar atrophy (8), burns (7), fasting hypoglycemia (7), persistent fetal circulation syndrome (7), pituitary gland disease (7), diabetes insipidus (7), drug dependence (7), anxiety disorder (6), allergic urticaria (6), amenorrhea (6), gangliocytoma (6), mental depression (5), ectopic cushing syndrome (5), benign familial neonatal epilepsy (5), endocrine organ benign neoplasm (5), withdrawal disorder (4), premenstrual tension (4), binswanger's disease (4), epilepsy, nocturnal frontal lobe, 1 (4), pulmonary immaturity (4), avoidant personality disorder (4), west syndrome (4), metaphyseal chondrodysplasia, murk jansen type (4), alzheimer disease (3), pheochromocytoma (2), gastrointestinal system disease (2), obesity (1), disease of mental health (1), organ system benign neoplasm (1), urinary system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.46 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 32.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.50186-0.239 Picture PostScript Text
3' UTR -114.00511-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018446 - Corticotropin-releasing_fac_CS
IPR000187 - Corticotropin-releasing_factor
IPR003620 - Urocortin_CRF

Pfam Domains:
PF00473 - Corticotropin-releasing factor family

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3EHT - X-ray 3EHU - X-ray


ModBase Predicted Comparative 3D Structure on P06850
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0017045 corticotropin-releasing hormone activity
GO:0051430 corticotropin-releasing hormone receptor 1 binding
GO:0051431 corticotropin-releasing hormone receptor 2 binding

Biological Process:
GO:0001934 positive regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0006704 glucocorticoid biosynthetic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0007611 learning or memory
GO:0008202 steroid metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008306 associative learning
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010700 negative regulation of norepinephrine secretion
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0010942 positive regulation of cell death
GO:0014062 regulation of serotonin secretion
GO:0016101 diterpenoid metabolic process
GO:0021854 hypothalamus development
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0032811 negative regulation of epinephrine secretion
GO:0033685 negative regulation of luteinizing hormone secretion
GO:0035641 locomotory exploration behavior
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035902 response to immobilization stress
GO:0042220 response to cocaine
GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045471 response to ethanol
GO:0045472 response to ether
GO:0048265 response to pain
GO:0050801 ion homeostasis
GO:0051412 response to corticosterone
GO:0051461 positive regulation of corticotropin secretion
GO:0051464 positive regulation of cortisol secretion
GO:0060291 long-term synaptic potentiation
GO:0060456 positive regulation of digestive system process
GO:0060548 negative regulation of cell death
GO:0070093 negative regulation of glucagon secretion
GO:0071314 cellular response to cocaine
GO:0071549 cellular response to dexamethasone stimulus
GO:0090280 positive regulation of calcium ion import
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000854 positive regulation of corticosterone secretion
GO:2000987 positive regulation of behavioral fear response

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0043025 neuronal cell body
GO:0043196 varicosity
GO:0043204 perikaryon


-  Descriptions from all associated GenBank mRNAs
  KJ896643 - Synthetic construct Homo sapiens clone ccsbBroadEn_06037 CRH gene, encodes complete protein.
AK075431 - Homo sapiens cDNA PSEC0122 fis, clone PLACE1003337, highly similar to CORTICOLIBERIN PRECURSOR.
LF206082 - JP 2014500723-A/13585: Polycomb-Associated Non-Coding RNAs.
JD377206 - Sequence 358230 from Patent EP1572962.
BC011031 - Homo sapiens corticotropin releasing hormone, mRNA (cDNA clone MGC:13636 IMAGE:4280754), complete cds.
JD219200 - Sequence 200224 from Patent EP1572962.
JD038032 - Sequence 19056 from Patent EP1572962.
LF351191 - JP 2014500723-A/158694: Polycomb-Associated Non-Coding RNAs.
JD445453 - Sequence 426477 from Patent EP1572962.
JD434315 - Sequence 415339 from Patent EP1572962.
JD491368 - Sequence 472392 from Patent EP1572962.
BC002599 - Homo sapiens corticotropin releasing hormone, mRNA (cDNA clone MGC:1770 IMAGE:3160933), complete cds.
JD409994 - Sequence 391018 from Patent EP1572962.
BT007453 - Homo sapiens corticotropin releasing hormone mRNA, complete cds.
AB590736 - Synthetic construct DNA, clone: pFN21AE1683, Homo sapiens CRH gene for corticotropin releasing hormone, without stop codon, in Flexi system.
KU177994 - Homo sapiens corticotropin releasing hormone isoform 1 (CRH) mRNA, partial cds.
KU177995 - Homo sapiens corticotropin releasing hormone isoform 2 (CRH) mRNA, complete cds, alternatively spliced.
JD318651 - Sequence 299675 from Patent EP1572962.
LF351192 - JP 2014500723-A/158695: Polycomb-Associated Non-Coding RNAs.
JD339575 - Sequence 320599 from Patent EP1572962.
JD214238 - Sequence 195262 from Patent EP1572962.
JD330197 - Sequence 311221 from Patent EP1572962.
MA586768 - JP 2018138019-A/158694: Polycomb-Associated Non-Coding RNAs.
MA586769 - JP 2018138019-A/158695: Polycomb-Associated Non-Coding RNAs.
MA441659 - JP 2018138019-A/13585: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P06850 (Reactome details) participates in the following event(s):

R-HSA-8937613 CRHBP binds CRH
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-420173 CRHR1,CRHR2-1 binds CRH,UCN
R-HSA-8937631 CRHR2-2 binds CRH,UCN,UCN2,UCN3
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-418555 G alpha (s) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQS4, CRF_HUMAN, ENST00000276571.1, ENST00000276571.2, ENST00000276571.3, ENST00000276571.4, NM_000756, P06850, uc317jku.1, uc317jku.2
UCSC ID: ENST00000276571.5_7
RefSeq Accession: NM_000756.4
Protein: P06850 (aka CRF_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene CRH:
adnfle (Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.