Human Gene CRIP2 (ENST00000329146.9_4) from GENCODE V47lift37
  Description: cysteine rich protein 2, transcript variant 1 (from RefSeq NM_001312.4)
Gencode Transcript: ENST00000329146.9_4
Gencode Gene: ENSG00000182809.11_6
Transcript (Including UTRs)
   Position: hg19 chr14:105,941,158-105,946,499 Size: 5,342 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr14:105,941,200-105,945,990 Size: 4,791 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:105,941,158-105,946,499)mRNA (may differ from genome)Protein (208 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CRIP2_HUMAN
DESCRIPTION: RecName: Full=Cysteine-rich protein 2; Short=CRP-2; AltName: Full=Protein ESP1;
SUBUNIT: Interacts with TGFB1I1 (By similarity).
TISSUE SPECIFICITY: Widespread tissue expression; highest levels in the heart.
SIMILARITY: Contains 2 LIM zinc-binding domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 170.17 RPKM in Heart - Atrial Appendage
Total median expression: 1998.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.2042-0.433 Picture PostScript Text
3' UTR -188.60509-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001781 - Znf_LIM

Pfam Domains:
PF00412 - LIM domain

SCOP Domains:
48695 - Multiheme cytochromes
57716 - Glucocorticoid receptor-like (DNA-binding domain)
161229 - E6 C-terminal domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CU8 - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P52943
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0008284 positive regulation of cell proliferation
GO:0030097 hemopoiesis

Cellular Component:
GO:0005938 cell cortex


-  Descriptions from all associated GenBank mRNAs
  AK300092 - Homo sapiens cDNA FLJ56946 complete cds, highly similar to Cysteine-rich protein 2.
AK057837 - Homo sapiens cDNA FLJ25108 fis, clone CBR01507.
BC034151 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:32803 IMAGE:4690443), complete cds.
AK315757 - Homo sapiens cDNA, FLJ96869, Homo sapiens cysteine-rich protein 2 (CRIP2), mRNA.
U36190 - Human cysteine-rich protein 2 (hCRP2) mRNA, complete cds.
BC128101 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:149180 IMAGE:40109449), complete cds.
BC034386 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone IMAGE:5198339), with apparent retained intron.
D42123 - Homo sapiens mRNA for cystein-rich protein 2, complete cds.
BC000434 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:8366 IMAGE:2819982), complete cds.
BC001931 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:3996 IMAGE:2819982), complete cds.
DQ894559 - Synthetic construct Homo sapiens clone IMAGE:100009019; FLH176392.01L; RZPDo839C10121D cysteine-rich protein 2 (CRIP2) gene, encodes complete protein.
DQ891382 - Synthetic construct clone IMAGE:100004012; FLH176396.01X; RZPDo839C10122D cysteine-rich protein 2 (CRIP2) gene, encodes complete protein.
AB528485 - Synthetic construct DNA, clone: pF1KB6939, Homo sapiens CRIP2 gene for cysteine-rich protein 2, without stop codon, in Flexi system.
KJ890970 - Synthetic construct Homo sapiens clone ccsbBroadEn_00364 CRIP2 gene, encodes complete protein.
BT019911 - Homo sapiens cysteine-rich protein 2 mRNA, complete cds.
AK223251 - Homo sapiens mRNA for cysteine-rich protein 2 variant, clone: STM06668.
AK091845 - Homo sapiens cDNA FLJ34526 fis, clone HLUNG2007433.
AX747217 - Sequence 742 from Patent EP1308459.
AK311402 - Homo sapiens cDNA, FLJ18444.
JD026057 - Sequence 7081 from Patent EP1572962.
JD034102 - Sequence 15126 from Patent EP1572962.
JD231045 - Sequence 212069 from Patent EP1572962.
JD474642 - Sequence 455666 from Patent EP1572962.
JD283801 - Sequence 264825 from Patent EP1572962.
JD390228 - Sequence 371252 from Patent EP1572962.
JD140984 - Sequence 122008 from Patent EP1572962.
JD161348 - Sequence 142372 from Patent EP1572962.
JD555017 - Sequence 536041 from Patent EP1572962.
JD482175 - Sequence 463199 from Patent EP1572962.
JD447918 - Sequence 428942 from Patent EP1572962.
JD197977 - Sequence 179001 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1A4U1, B7Z6C0, CRIP2_HUMAN, CRP2, E9PD13, ENST00000329146.1, ENST00000329146.2, ENST00000329146.3, ENST00000329146.4, ENST00000329146.5, ENST00000329146.6, ENST00000329146.7, ENST00000329146.8, NM_001312, P52943, uc317sra.1, uc317sra.2
UCSC ID: ENST00000329146.9_4
RefSeq Accession: NM_001312.4
Protein: P52943 (aka CRIP2_HUMAN or CRP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.