ID:CRNN_HUMAN DESCRIPTION: RecName: Full=Cornulin; AltName: Full=53 kDa putative calcium-binding protein; AltName: Full=53 kDa squamous epithelial-induced stress protein; AltName: Full=58 kDa heat shock protein; AltName: Full=Squamous epithelial heat shock protein 53; AltName: Full=Tumor-related protein; FUNCTION: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. COFACTOR: Binds calcium. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. Note=Does not colocalize with TGM1. TISSUE SPECIFICITY: Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). INDUCTION: Up-regulated after heat shock, ponasterone A and deoxycholic acid. DOMAIN: The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA. MISCELLANEOUS: Binds calcium with an affinity similar to that of the S100 proteins. SIMILARITY: Belongs to the S100-fused protein family. SIMILARITY: Contains 1 EF-hand domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBG3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
