Human Gene CSH2 (ENST00000392886.7_7) from GENCODE V47lift37
  Description: chorionic somatomammotropin hormone 2, transcript variant 1 (from RefSeq NM_020991.4)
Gencode Transcript: ENST00000392886.7_7
Gencode Gene: ENSG00000213218.11_9
Transcript (Including UTRs)
   Position: hg19 chr17:61,949,376-61,951,037 Size: 1,662 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr17:61,949,486-61,950,974 Size: 1,489 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:61,949,376-61,951,037)mRNA (may differ from genome)Protein (217 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CSH2
Diseases sorted by gene-association score: choriocarcinoma (7), testicular trophoblastic tumor (4), juvenile type testicular granulosa cell tumor (2), testicular granulosa cell tumor (2), gestational trophoblastic neoplasm (2), germ cell and embryonal cancer (2), choriocarcinoma of the testis (2), non-gestational choriocarcinoma (2), uterine disease (2), choriocarcinoma of ovary (1), rh isoimmunization (1), female reproductive system disease (1), chronic salpingitis (1), breast metaplastic carcinoma (1), noonan syndrome 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.81 RPKM in Testis
Total median expression: 0.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.8063-0.203 Picture PostScript Text
3' UTR -26.00110-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  BC035965 - Homo sapiens chorionic somatomammotropin hormone 2, mRNA (cDNA clone MGC:32544 IMAGE:4731880), complete cds.
BC022044 - Homo sapiens chorionic somatomammotropin hormone 2, mRNA (cDNA clone MGC:27151 IMAGE:4769046), complete cds.
V00573 - Human mRNA encoding placental lactogen hormone.
JD255527 - Sequence 236551 from Patent EP1572962.
JD081364 - Sequence 62388 from Patent EP1572962.
JD081365 - Sequence 62389 from Patent EP1572962.
JD124037 - Sequence 105061 from Patent EP1572962.
BC119748 - Homo sapiens chorionic somatomammotropin hormone 2, mRNA (cDNA clone MGC:149869 IMAGE:40119242), complete cds.
JD146361 - Sequence 127385 from Patent EP1572962.
JD225459 - Sequence 206483 from Patent EP1572962.
DQ892826 - Synthetic construct clone IMAGE:100005456; FLH190067.01X; RZPDo839E0275D chorionic somatomammotropin hormone 2 (CSH2) gene, encodes complete protein.
KJ890980 - Synthetic construct Homo sapiens clone ccsbBroadEn_00374 CSH2 gene, encodes complete protein.
CU678142 - Synthetic construct Homo sapiens gateway clone IMAGE:100018593 5' read CSH1 mRNA.
DQ896072 - Synthetic construct Homo sapiens clone IMAGE:100010532; FLH190063.01L; RZPDo839E0265D chorionic somatomammotropin hormone 2 (CSH2) gene, encodes complete protein.
JD139944 - Sequence 120968 from Patent EP1572962.
JD096841 - Sequence 77865 from Patent EP1572962.
JD139706 - Sequence 120730 from Patent EP1572962.
JD512426 - Sequence 493450 from Patent EP1572962.
JD186554 - Sequence 167578 from Patent EP1572962.
JD131309 - Sequence 112333 from Patent EP1572962.
JD521211 - Sequence 502235 from Patent EP1572962.
JD145946 - Sequence 126970 from Patent EP1572962.
JD438144 - Sequence 419168 from Patent EP1572962.
JD049395 - Sequence 30419 from Patent EP1572962.
JD438161 - Sequence 419185 from Patent EP1572962.
JD438162 - Sequence 419186 from Patent EP1572962.
JD438159 - Sequence 419183 from Patent EP1572962.
JD438160 - Sequence 419184 from Patent EP1572962.
JD256205 - Sequence 237229 from Patent EP1572962.
JD324980 - Sequence 306004 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CSH2_HUMAN, ENST00000392886.1, ENST00000392886.2, ENST00000392886.3, ENST00000392886.4, ENST00000392886.5, ENST00000392886.6, NM_020991, P01243, P0DML3, Q0VDB1, Q14407, uc318vlh.1, uc318vlh.2
UCSC ID: ENST00000392886.7_7
RefSeq Accession: NM_020991.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.