ID:KC1A_HUMAN DESCRIPTION: RecName: Full=Casein kinase I isoform alpha; Short=CKI-alpha; EC=2.7.11.1; AltName: Full=CK1; FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. INTERACTION: Q00987:MDM2; NbExp=3; IntAct=EBI-2040168, EBI-389668; Q13546:RIPK1; NbExp=5; IntAct=EBI-1383726, EBI-358507; SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. SIMILARITY: Contains 1 protein kinase domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/CSNK1A1ID40168ch5q32.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase PF17667 - Fungal protein kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P48729
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC008717 - Homo sapiens casein kinase 1, alpha 1, mRNA (cDNA clone MGC:8504 IMAGE:2822250), complete cds. AK294099 - Homo sapiens cDNA FLJ51815 complete cds, highly similar to Homo sapiens casein kinase 1, alpha 1 (CSNK1A1), transcript variant 1, mRNA. AK293761 - Homo sapiens cDNA FLJ55317 complete cds, highly similar to Homo sapiens casein kinase 1, alpha 1 (CSNK1A1), transcript variant 1, mRNA. AK303794 - Homo sapiens cDNA FLJ55318 complete cds, highly similar to Casein kinase I isoform alpha (EC 2.7.11.1). AF218004 - Homo sapiens clone PP2684 unknown mRNA. AK294942 - Homo sapiens cDNA FLJ56335 complete cds, highly similar to Casein kinase I isoform alpha (EC 2.7.11.1). L37042 - Homo sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds. X80693 - H.sapiens mRNA for protein kinase CK1. BT019829 - Homo sapiens casein kinase 1, alpha 1 mRNA, complete cds. BT019830 - Homo sapiens casein kinase 1, alpha 1 mRNA, complete cds. CR542206 - Homo sapiens full open reading frame cDNA clone RZPDo834H1224D for gene CSNK1A1, casein kinase 1, alpha 1; complete cds, incl. stopcodon. DQ082865 - Homo sapiens casein kinase 1 alpha 1 (CSNK1A1) mRNA, complete cds, alternatively spliced. EU668329 - Homo sapiens epididymis secretory sperm binding protein Li 77p (HEL-S-77p) mRNA, partial cds. KJ896661 - Synthetic construct Homo sapiens clone ccsbBroadEn_06055 CSNK1A1 gene, encodes complete protein. AB385127 - Synthetic construct DNA, clone: pF1KB5585, Homo sapiens CSNK1A1 gene for casein kinase I isoform alpha, complete cds, without stop codon, in Flexi system. BC021971 - Homo sapiens casein kinase 1, alpha 1, mRNA (cDNA clone IMAGE:3936929), partial cds. BC025371 - Homo sapiens casein kinase 1, alpha 1, mRNA (cDNA clone IMAGE:4025440), partial cds. BC007246 - Homo sapiens casein kinase 1, alpha 1, mRNA (cDNA clone IMAGE:2966714), partial cds. JD413482 - Sequence 394506 from Patent EP1572962. JD198177 - Sequence 179201 from Patent EP1572962. JD337481 - Sequence 318505 from Patent EP1572962. BC029454 - Homo sapiens cDNA clone IMAGE:4044084. AF447582 - Homo sapiens HLCDGP1 mRNA, complete cds. BX647478 - Homo sapiens mRNA; cDNA DKFZp686D05110 (from clone DKFZp686D05110). BC040473 - Homo sapiens, clone IMAGE:4769127, mRNA. AF119911 - Homo sapiens PRO2975 mRNA, complete cds. BC105984 - Homo sapiens cDNA clone IMAGE:3448600. BC020446 - Homo sapiens cDNA clone IMAGE:3448942. BC009186 - Homo sapiens cDNA clone IMAGE:4079854, partial cds. JD273380 - Sequence 254404 from Patent EP1572962. JD267264 - Sequence 248288 from Patent EP1572962. JD086163 - Sequence 67187 from Patent EP1572962. JD113665 - Sequence 94689 from Patent EP1572962. JD454872 - Sequence 435896 from Patent EP1572962. JD332529 - Sequence 313553 from Patent EP1572962. BX648552 - Homo sapiens mRNA; cDNA DKFZp779B1535 (from clone DKFZp779B1535). JD420614 - Sequence 401638 from Patent EP1572962. JD425518 - Sequence 406542 from Patent EP1572962. JD469766 - Sequence 450790 from Patent EP1572962. JD552526 - Sequence 533550 from Patent EP1572962. JD290056 - Sequence 271080 from Patent EP1572962. JD562353 - Sequence 543377 from Patent EP1572962. JD205492 - Sequence 186516 from Patent EP1572962. JD176959 - Sequence 157983 from Patent EP1572962. JD168723 - Sequence 149747 from Patent EP1572962. JD091860 - Sequence 72884 from Patent EP1572962. JD048675 - Sequence 29699 from Patent EP1572962. JD088276 - Sequence 69300 from Patent EP1572962. JD164425 - Sequence 145449 from Patent EP1572962. JD261436 - Sequence 242460 from Patent EP1572962. JD190727 - Sequence 171751 from Patent EP1572962. JD029411 - Sequence 10435 from Patent EP1572962. JD019652 - Sequence 676 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
Reactome (by CSHL, EBI, and GO)
Protein P48729 (Reactome details) participates in the following event(s):
R-HSA-195251 Assembly of the destruction complex R-HSA-201685 Beta-catenin is released from the destruction complex R-HSA-5632671 CSNK1A1 binds SMO dimer R-HSA-5633040 CSNK1A1 and ADRBK1 dissociate from p-SMO dimer R-HSA-5229343 AXIN is phosphorylated in the destruction complex R-HSA-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex R-HSA-195275 Phosphorylation of APC component of the destruction complex R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex R-HSA-195304 Association of beta-catenin with the destruction complex R-HSA-5610718 CK1 phosphorylates p-GLI2 R-HSA-5610722 CK1 phosphorylates p-GLI3 R-HSA-5632670 CSNK1A1 phosphorylates SMO dimer R-HSA-5632672 ADRBK1 phosphorylates SMO dimer R-HSA-5632674 ADRBK1 binds phosphorylated SMO dimer R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-5467337 APC truncation mutants have impaired AXIN binding R-HSA-5467340 AXIN missense mutants destabilize the destruction complex R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5635838 Activation of SMO R-HSA-195721 Signaling by WNT R-HSA-4839744 truncated APC mutants destabilize the destruction complex R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling R-HSA-4839748 AMER1 mutants destabilize the destruction complex R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-5610783 Degradation of GLI2 by the proteasome R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome R-HSA-5632684 Hedgehog 'on' state R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated R-HSA-196299 Beta-catenin phosphorylation cascade R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-162582 Signal Transduction R-HSA-4791275 Signaling by WNT in cancer R-HSA-5610787 Hedgehog 'off' state R-HSA-5358351 Signaling by Hedgehog R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
