Human Gene CSNK1E (ENST00000396832.6_10) from GENCODE V47lift37
  Description: casein kinase 1 epsilon, transcript variant 1 (from RefSeq NM_152221.3)
Gencode Transcript: ENST00000396832.6_10
Gencode Gene: ENSG00000213923.13_15
Transcript (Including UTRs)
   Position: hg19 chr22:38,686,697-38,713,438 Size: 26,742 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr22:38,689,293-38,710,162 Size: 20,870 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:38,686,697-38,713,438)mRNA (may differ from genome)Protein (416 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CSNK1E
Diseases sorted by gene-association score: advanced sleep phase syndrome (12)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.99 RPKM in Cervix - Endocervix
Total median expression: 1148.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -179.70286-0.628 Picture PostScript Text
3' UTR -421.701280-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase
PF17667 - Fungal protein kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q5U045
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation


-  Descriptions from all associated GenBank mRNAs
  KJ890985 - Synthetic construct Homo sapiens clone ccsbBroadEn_00379 CSNK1E gene, encodes complete protein.
KJ905184 - Synthetic construct Homo sapiens clone ccsbBroadEn_14601 CSNK1E gene, encodes complete protein.
KR710027 - Synthetic construct Homo sapiens clone CCSBHm_00009046 CSNK1E (CSNK1E) mRNA, encodes complete protein.
BC013088 - Homo sapiens casein kinase 1, epsilon, mRNA (cDNA clone IMAGE:3452986), with apparent retained intron.
JD068818 - Sequence 49842 from Patent EP1572962.
JD391027 - Sequence 372051 from Patent EP1572962.
CR456429 - Homo sapiens CSNK1E full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.CSNK1E).
BC006490 - Homo sapiens casein kinase 1, epsilon, mRNA (cDNA clone MGC:10398 IMAGE:3937782), complete cds.
AB091043 - Homo sapiens CKIe mRNA for casein kinase I epsilon, complete cds.
AK223498 - Homo sapiens mRNA for casein kinase 1 epsilon variant, clone: FCC121A06.
AB024597 - Homo sapiens mRNA for casein kinase I epsilon, complete cds.
AK092269 - Homo sapiens cDNA FLJ34950 fis, clone NT2RP7017284, highly similar to Casein kinase I isoform epsilon (EC 2.7.11.1).
L37043 - Homo sapiens casein kinase I epsilon mRNA, complete cds.
JD277117 - Sequence 258141 from Patent EP1572962.
CU012990 - Homo sapiens CSNK1E, mRNA (cDNA clone IMAGE:100000151), complete cds, with stop codon, in Gateway system.
DQ895852 - Synthetic construct Homo sapiens clone IMAGE:100010312; FLH188311.01L; RZPDo839B0163D casein kinase 1, epsilon (CSNK1E) gene, encodes complete protein.
BT019831 - Homo sapiens casein kinase 1, epsilon mRNA, complete cds.
DQ892612 - Synthetic construct clone IMAGE:100005242; FLH188315.01X; RZPDo839B0173D casein kinase 1, epsilon (CSNK1E) gene, encodes complete protein.
CU013278 - Homo sapiens CSNK1E, mRNA (cDNA clone IMAGE:100000055), complete cds, without stop codon, in Gateway system.
AB384860 - Synthetic construct DNA, clone: pF1KB3818, Homo sapiens CSNK1E gene for casein kinase I isoform epsilon, complete cds, without stop codon, in Flexi system.
AK310303 - Homo sapiens cDNA, FLJ17345.
JD297407 - Sequence 278431 from Patent EP1572962.
JD378582 - Sequence 359606 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_circadianPathway - Circadian Rhythms

-  Other Names for This Gene
  Alternate Gene Symbols: CSNK1E , ENST00000396832.1, ENST00000396832.2, ENST00000396832.3, ENST00000396832.4, ENST00000396832.5, hCG_2014051 , NM_152221, Q5U045, Q5U045_HUMAN, uc318ynd.1, uc318ynd.2
UCSC ID: ENST00000396832.6_10
RefSeq Accession: NM_152221.3
Protein: Q5U045

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.