Human Gene CSNK2B (ENST00000375882.7_6) from GENCODE V47lift37
  Description: casein kinase 2 beta, transcript variant 1 (from RefSeq NM_001320.7)
Gencode Transcript: ENST00000375882.7_6
Gencode Gene: ENSG00000204435.15_9
Transcript (Including UTRs)
   Position: hg19 chr6:31,633,857-31,637,844 Size: 3,988 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr6:31,634,609-31,637,703 Size: 3,095 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,633,857-31,637,844)mRNA (may differ from genome)Protein (215 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CSK2B_HUMAN
DESCRIPTION: RecName: Full=Casein kinase II subunit beta; Short=CK II beta; AltName: Full=Phosvitin; AltName: Full=Protein G5a;
FUNCTION: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
SUBUNIT: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2.
INTERACTION: Self; NbExp=6; IntAct=EBI-348169, EBI-348169; O00257-3:CBX4; NbExp=2; IntAct=EBI-348169, EBI-4392727; P68400:CSNK2A1; NbExp=10; IntAct=EBI-348169, EBI-347804; P19784:CSNK2A2; NbExp=4; IntAct=EBI-348169, EBI-347451;
PTM: Phosphorylated by alpha subunit.
SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
SEQUENCE CAUTION: Sequence=CAI18393.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CSNK2B
Diseases sorted by gene-association score: egg allergy (12)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 181.44 RPKM in Testis
Total median expression: 3400.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.10140-0.315 Picture PostScript Text
3' UTR -26.90141-0.191 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016149 - Casein_kin_II_reg-sub_a-hlx
IPR016150 - Casein_kin_II_reg-sub_b-sht
IPR000704 - Casein_kinase_II_reg-sub

Pfam Domains:
PF01214 - Casein kinase II regulatory subunit

SCOP Domains:
89009 - GAT-like domain
52374 - Nucleotidylyl transferase
57798 - Casein kinase II beta subunit

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1DS5 - X-ray 1JWH - X-ray MuPIT 1QF8 - X-ray MuPIT 3EED - X-ray MuPIT 4DGL - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P67870
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0004674 protein serine/threonine kinase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019887 protein kinase regulator activity
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding

Biological Process:
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016055 Wnt signaling pathway
GO:0018107 peptidyl-threonine phosphorylation
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0033211 adiponectin-activated signaling pathway
GO:0033574 response to testosterone
GO:0034622 cellular macromolecular complex assembly
GO:0043312 neutrophil degranulation
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045859 regulation of protein kinase activity
GO:0051101 regulation of DNA binding
GO:0061154 endothelial tube morphogenesis
GO:0097421 liver regeneration
GO:1901796 regulation of signal transduction by p53 class mediator

Cellular Component:
GO:0000785 chromatin
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0005956 protein kinase CK2 complex
GO:0016363 nuclear matrix
GO:0034774 secretory granule lumen
GO:0042995 cell projection
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen
GO:0031519 PcG protein complex


-  Descriptions from all associated GenBank mRNAs
  BC112019 - Homo sapiens casein kinase 2, beta polypeptide, mRNA (cDNA clone MGC:138224 IMAGE:8327487), complete cds.
BC112017 - Homo sapiens casein kinase 2, beta polypeptide, mRNA (cDNA clone MGC:138222 IMAGE:8327485), complete cds.
AK310551 - Homo sapiens cDNA, FLJ17593.
AK308742 - Homo sapiens cDNA, FLJ98783.
AK300671 - Homo sapiens cDNA FLJ50688 complete cds, highly similar to Casein kinase II subunit beta.
X16312 - Human mRNA for phosvitin/casein kinase II beta subunit.
X16937 - Human mRNA for phosvitin/casein kinase type II beta subunit (EC 2.7.1.37).
AK310954 - Homo sapiens cDNA, FLJ17996.
AK311860 - Homo sapiens cDNA, FLJ92126, Homo sapiens casein kinase 2, beta polypeptide (CSNK2B), mRNA.
M30448 - Human casein kinase II beta subunit mRNA, complete cds.
HE864443 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 132 (CSNK2B gene).
HE864444 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 247 (CSNK2B gene).
HE864445 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 318 (CSNK2B gene).
HE864446 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 660 (CSNK2B gene).
HE864447 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 806 (CSNK2B gene).
HE864452 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 182 (CSNK2B-LY6G5B-182 gene).
HE864453 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 532 (CSNK2B-LY6G5B-532 gene).
HE864454 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 560 (CSNK2B-LY6G5B-560 gene).
HE864455 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 562 (CSNK2B-LY6G5B-562 gene).
HE864456 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 696 (CSNK2B-LY6G5B-696 gene).
HE864457 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 991 (CSNK2B-LY6G5B--991 gene).
HE864459 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1103 (CSNK2B-LY6G5B-1103 gene).
HE864460 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1181 (CSNK2B-LY6G5B-1181 gene).
HE864461 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1327 (CSNK2B-LY6G5B-1327 gene).
HE864458 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1072 (CSNK2B-LY6G5B-1072 gene).
AB590710 - Synthetic construct DNA, clone: pFN21AE1709, Homo sapiens CSNK2B gene for casein kinase 2, beta polypeptide, without stop codon, in Flexi system.
CR541699 - Homo sapiens full open reading frame cDNA clone RZPDo834F0628D for gene CSNK2B, casein kinase 2, beta polypeptide; complete cds, without stopcodon.
KJ896664 - Synthetic construct Homo sapiens clone ccsbBroadEn_06058 CSNK2B gene, encodes complete protein.
AY113186 - Homo sapiens casein kinase II beta subunit mRNA, complete cds.
JD189458 - Sequence 170482 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P67870 (Reactome details) participates in the following event(s):

R-HSA-392752 Phosphorylation of L1 by CK-II
R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-6805061 CK2 binds FACT
R-HSA-201717 CSNK2-mediated phosphorylation of DVL
R-HSA-2529020 CK2 phosphorylates condensin I subunits
R-HSA-6814409 CK2 phosphorylates PDCL
R-HSA-8948039 FUNDC1 is phosphorylated by CK2
R-HSA-8850945 Casein kinase II phosphorylates PTEN
R-HSA-8873929 Casein kinase II phosphorylates STARD10
R-HSA-6805059 CK2:FACT phosphorylates TP53
R-HSA-8937989 RUNX1 binds PRC1 complexes
R-HSA-445144 Signal transduction by L1
R-HSA-6798695 Neutrophil degranulation
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-373760 L1CAM interactions
R-HSA-201688 WNT mediated activation of DVL
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-1483191 Synthesis of PC
R-HSA-168249 Innate Immune System
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-422475 Axon guidance
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-68877 Mitotic Prometaphase
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-5205647 Mitophagy
R-HSA-6807070 PTEN Regulation
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-168256 Immune System
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-1266738 Developmental Biology
R-HSA-195721 Signaling by WNT
R-HSA-68886 M Phase
R-HSA-391251 Protein folding
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1483257 Phospholipid metabolism
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-212436 Generic Transcription Pathway
R-HSA-162582 Signal Transduction
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-392499 Metabolism of proteins
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-556833 Metabolism of lipids
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-1640170 Cell Cycle
R-HSA-1430728 Metabolism
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B0UXA9, CK2N, CSK2B_HUMAN, CSNK2B , ENST00000375882.1, ENST00000375882.2, ENST00000375882.3, ENST00000375882.4, ENST00000375882.5, ENST00000375882.6, G5A, NM_001320, P07312, P13862, P67870, Q4VX47, uc318mos.1, uc318mos.2
UCSC ID: ENST00000375882.7_6
RefSeq Accession: NM_001320.7
Protein: P67870 (aka CSK2B_HUMAN or KC2B_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene CSNK2B:
csnk2b-ndd (CSNK2B-Related Neurodevelopmental Disorder)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.