Human Gene CSRP1 (ENST00000340006.7_8) from GENCODE V47lift37

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Description: cysteine and glycine rich protein 1, transcript variant 1 (from RefSeq NM_004078.3)
Gencode Transcript: ENST00000340006.7_8
Gencode Gene: ENSG00000159176.14_10
Transcript (Including UTRs)
Position: hg19 chr1:201,452,658-201,476,251 Size: 23,594 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr1:201,453,841-201,465,431 Size: 11,591 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:201,452,658-201,476,251)			mRNA (may differ from genome)		Protein (193 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CSRP1_HUMAN DESCRIPTION: RecName: Full=Cysteine and glycine-rich protein 1; AltName: Full=Cysteine-rich protein 1; Short=CRP; Short=CRP1; FUNCTION: Could play a role in neuronal development. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 2 LIM zinc-binding domains.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CSRP1 Diseases sorted by gene-association score: pontiac fever (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C006253 pirinixic acid D003993 Dibutyl Phthalate C014211 2,3,7,8-tetrachlorodibenzofuran C430898 AGN 194204 D000393 Air Pollutants D000638 Amiodarone D000643 Ammonium Chloride D001205 Ascorbic Acid D001553 Benzbromarone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 935.74 RPKM in Colon - Sigmoid Total median expression: 9063.07 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-10.10	55	-0.184	Picture	PostScript	Text
3' UTR	-433.10	1183	-0.366	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001781 - Znf_LIM

Pfam Domains:
PF00412 - LIM domain

SCOP Domains:
48695 - Multiheme cytochromes
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on P21291


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0008270 zinc ion binding GO:0046872 metal ion binding Biological Process: GO:0070527 platelet aggregation Cellular Component: GO:0005634 nucleus GO:0005925 focal adhesion GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BX537488 - Homo sapiens mRNA; cDNA DKFZp686P2249 (from clone DKFZp686P2249). CR627407 - Homo sapiens mRNA; cDNA DKFZp686M148 (from clone DKFZp686M148). BC004265 - Homo sapiens, Similar to cysteine and glycine-rich protein 1, clone IMAGE:3611639, mRNA, partial cds. GQ472204 - Homo sapiens epididymis secretory protein Li 286 (HEL-S-286) mRNA, partial cds. BC007492 - Homo sapiens cysteine and glycine-rich protein 1, mRNA (cDNA clone IMAGE:2966961). BC032493 - Homo sapiens cysteine and glycine-rich protein 1, mRNA (cDNA clone MGC:40335 IMAGE:5244276), complete cds. GQ891413 - Homo sapiens clone HEL-S-134 epididymis secretory sperm binding protein mRNA, complete cds. BC018806 - Homo sapiens cysteine and glycine-rich protein 1, mRNA (cDNA clone IMAGE:4872630). M33146 - Human cysteine-rich peptide mRNA, complete cds. AK131508 - Homo sapiens cDNA FLJ16726 fis, clone UTERU3014791. AB209756 - Homo sapiens mRNA for cysteine and glycine-rich protein 1 variant protein. EU668320 - Homo sapiens epididymis luminal protein 141 (HEL-141) mRNA, complete cds. AK057876 - Homo sapiens cDNA FLJ25147 fis, clone CBR07369. AK122812 - Homo sapiens cDNA FLJ16406 fis, clone UTERU2026142, highly similar to Cysteine and glycine-rich protein 1. AK293053 - Homo sapiens cDNA FLJ75177 complete cds, highly similar to Homo sapiens cysteine and glycine-rich protein 1 (CSRP1), mRNA. AK302237 - Homo sapiens cDNA FLJ61189 complete cds, highly similar to Cysteine and glycine-rich protein 1. AK290133 - Homo sapiens cDNA FLJ77815 complete cds, highly similar to Homo sapiens cysteine and glycine-rich protein 1 (CSRP1), mRNA. KJ896665 - Synthetic construct Homo sapiens clone ccsbBroadEn_06059 CSRP1 gene, encodes complete protein. BT019520 - Homo sapiens cysteine and glycine-rich protein 1 mRNA, complete cds. AB527927 - Synthetic construct DNA, clone: pF1KB0961, Homo sapiens CSRP1 gene for cysteine and glycine-rich protein 1, without stop codon, in Flexi system. AK304415 - Homo sapiens cDNA FLJ54121 complete cds, highly similar to Cysteine and glycine-rich protein 1. BX641046 - Homo sapiens mRNA; cDNA DKFZp686O2015 (from clone DKFZp686O2015). JD086611 - Sequence 67635 from Patent EP1572962. AK126445 - Homo sapiens cDNA FLJ44481 fis, clone UTERU2032726. AK126507 - Homo sapiens cDNA FLJ44543 fis, clone UTERU3005767. JD214270 - Sequence 195294 from Patent EP1572962. JD074038 - Sequence 55062 from Patent EP1572962. JD190796 - Sequence 171820 from Patent EP1572962. JD148902 - Sequence 129926 from Patent EP1572962. JD324742 - Sequence 305766 from Patent EP1572962. JD163312 - Sequence 144336 from Patent EP1572962. JD324744 - Sequence 305768 from Patent EP1572962. JD424494 - Sequence 405518 from Patent EP1572962. JD134262 - Sequence 115286 from Patent EP1572962. JD538125 - Sequence 519149 from Patent EP1572962. JD030200 - Sequence 11224 from Patent EP1572962. JD025278 - Sequence 6302 from Patent EP1572962. JD183235 - Sequence 164259 from Patent EP1572962. JD046575 - Sequence 27599 from Patent EP1572962. JD044275 - Sequence 25299 from Patent EP1572962. JD191658 - Sequence 172682 from Patent EP1572962. JD273536 - Sequence 254560 from Patent EP1572962. JD180450 - Sequence 161474 from Patent EP1572962. JD467817 - Sequence 448841 from Patent EP1572962. JD300870 - Sequence 281894 from Patent EP1572962. JD094829 - Sequence 75853 from Patent EP1572962. JD067132 - Sequence 48156 from Patent EP1572962. JD540944 - Sequence 521968 from Patent EP1572962. JD338474 - Sequence 319498 from Patent EP1572962. JD136790 - Sequence 117814 from Patent EP1572962. JD225512 - Sequence 206536 from Patent EP1572962. JD478886 - Sequence 459910 from Patent EP1572962. JD121488 - Sequence 102512 from Patent EP1572962. JD325692 - Sequence 306716 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P21291 (Reactome details) participates in the following event(s): R-HSA-5660489 MTF1 activates gene expression R-HSA-5660526 Response to metal ions R-HSA-8953897 Cellular responses to external stimuli

Other Names for This Gene


	Alternate Gene Symbols: A8K268, CSRP, CSRP1_HUMAN, CYRP, ENST00000340006.1, ENST00000340006.2, ENST00000340006.3, ENST00000340006.4, ENST00000340006.5, ENST00000340006.6, NM_004078, P21291, Q5U0J2, uc317vnn.1, uc317vnn.2 UCSC ID: ENST00000340006.7_8 RefSeq Accession: NM_004078.3 Protein: P21291 (aka CSRP1_HUMAN or CSR1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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