ID:CTBP2_HUMAN DESCRIPTION: RecName: Full=C-terminal-binding protein 2; Short=CtBP2; FUNCTION: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). FUNCTION: Isoform 2 probably acts as a scaffold for specialized synapses. SUBUNIT: Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ. INTERACTION: P20749:BCL3; NbExp=2; IntAct=EBI-741533, EBI-958997; P51946:CCNH; NbExp=5; IntAct=EBI-741533, EBI-741406; Q14526:HIC1; NbExp=2; IntAct=EBI-741533, EBI-2507362; O75807:PPP1R15A; NbExp=2; IntAct=EBI-741533, EBI-714746; Q92786:PROX1; NbExp=2; IntAct=EBI-741533, EBI-3912635; Q9UN79:SOX13; NbExp=2; IntAct=EBI-741533, EBI-3928516; A2APF7:Zbp1 (xeno); NbExp=2; IntAct=EBI-741533, EBI-6115394; SUBCELLULAR LOCATION: Nucleus (Potential). Cell junction, synapse (By similarity). TISSUE SPECIFICITY: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas. PTM: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR at Thr-179; Ser-181 and Ser-185. Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation (By similarity). SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56545
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016618 hydroxypyruvate reductase activity GO:0019901 protein kinase binding GO:0030267 glyoxylate reductase (NADP) activity GO:0042803 protein homodimerization activity GO:0044877 macromolecular complex binding GO:0051287 NAD binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0008152 metabolic process GO:0008285 negative regulation of cell proliferation GO:0016032 viral process GO:0019079 viral genome replication GO:0030154 cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048386 positive regulation of retinoic acid receptor signaling pathway GO:0050872 white fat cell differentiation GO:0055114 oxidation-reduction process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
