Human Gene CTNNA3 (ENST00000433211.7_7) from GENCODE V47lift37
  Description: catenin alpha 3, transcript variant 1 (from RefSeq NM_013266.4)
Gencode Transcript: ENST00000433211.7_7
Gencode Gene: ENSG00000183230.18_12
Transcript (Including UTRs)
   Position: hg19 chr10:67,672,281-69,455,953 Size: 1,783,673 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr10:67,680,088-69,407,271 Size: 1,727,184 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:67,672,281-69,455,953)mRNA (may differ from genome)Protein (895 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CTNA3_HUMAN
DESCRIPTION: RecName: Full=Catenin alpha-3; AltName: Full=Alpha T-catenin; AltName: Full=Cadherin-associated protein;
FUNCTION: May be involved in formation of stretch-resistant cell- cell adhesion complexes.
SUBUNIT: Interacts with CTNNB1.
INTERACTION: P04591:gag (xeno); NbExp=2; IntAct=EBI-3937546, EBI-6179727;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Potential). Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2.
TISSUE SPECIFICITY: Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.
SIMILARITY: Belongs to the vinculin/alpha-catenin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CTNNA3
Diseases sorted by gene-association score: arrhythmogenic right ventricular dysplasia, familial, 13* (1242), arrhythmogenic right ventricular dysplasia/cardiomyopathy13* (500), arrhythmogenic right ventricular cardiomyopathy* (251), familial isolated arrhythmogenic ventricular dysplasia, right dominant form* (101), familial isolated arrhythmogenic ventricular dysplasia, biventricular form* (101), familial isolated arrhythmogenic ventricular dysplasia, left dominant form* (101)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.09 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 56.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.40201-0.216 Picture PostScript Text
3' UTR -1823.107807-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001033 - Alpha_catenin
IPR006077 - Vinculin/catenin

Pfam Domains:
PF01044 - Vinculin family

SCOP Domains:
109885 - I/LWEQ domain
47220 - alpha-catenin/vinculin-like
46955 - Putative DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q9UI47
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding

Biological Process:
GO:0007155 cell adhesion
GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098609 cell-cell adhesion
GO:0098911 regulation of ventricular cardiac muscle cell action potential

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005912 adherens junction
GO:0005916 fascia adherens
GO:0030027 lamellipodium


-  Descriptions from all associated GenBank mRNAs
  AK289756 - Homo sapiens cDNA FLJ78082 complete cds, highly similar to Homo sapiens alphaT-catenin (CTNNA3) mRNA.
AF091606 - Homo sapiens alphaT-catenin (CTNNA3) mRNA, complete cds.
AK313882 - Homo sapiens cDNA, FLJ94516, highly similar to Homo sapiens catenin (cadherin-associated protein), alpha 3 (CTNNA3), mRNA.
AB590769 - Synthetic construct DNA, clone: pFN21AB8536, Homo sapiens CTNNA3 gene for catenin (cadherin-associated protein), alpha 3, without stop codon, in Flexi system.
BC065819 - Homo sapiens catenin (cadherin-associated protein), alpha 3, mRNA (cDNA clone MGC:75041 IMAGE:6189390), complete cds.
KJ902506 - Synthetic construct Homo sapiens clone ccsbBroadEn_11900 CTNNA3 gene, encodes complete protein.
AK308726 - Homo sapiens cDNA, FLJ98767.
BC022004 - Homo sapiens catenin (cadherin-associated protein), alpha 3, mRNA (cDNA clone IMAGE:4823848), complete cds.
BC030646 - Homo sapiens catenin (cadherin-associated protein), alpha 3, mRNA (cDNA clone IMAGE:4825293), complete cds.
AY198183 - Homo sapiens alpha-T-catenin isoform 2 (CTNNA3) mRNA, partial cds, alternatively spliced.
JD172500 - Sequence 153524 from Patent EP1572962.
JD244732 - Sequence 225756 from Patent EP1572962.
JD094354 - Sequence 75378 from Patent EP1572962.
JD174516 - Sequence 155540 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_cell2cellPathway - Cell to Cell Adhesion Signaling

-  Other Names for This Gene
  Alternate Gene Symbols: CTNA3_HUMAN, CTNNA3 , ENST00000433211.1, ENST00000433211.2, ENST00000433211.3, ENST00000433211.4, ENST00000433211.5, ENST00000433211.6, NM_013266, Q5VSR2, Q6P056, Q9UI47, uc320bum.1, uc320bum.2
UCSC ID: ENST00000433211.7_7
RefSeq Accession: NM_013266.4
Protein: Q9UI47 (aka CTNA3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.