ID:CTND2_HUMAN DESCRIPTION: RecName: Full=Catenin delta-2; AltName: Full=Delta-catenin; AltName: Full=GT24; AltName: Full=Neural plakophilin-related ARM-repeat protein; Short=NPRAP; AltName: Full=Neurojungin; FUNCTION: Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. SUBUNIT: Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). SUBCELLULAR LOCATION: Nucleus (By similarity). Cell junction, adherens junction (By similarity). Perikaryon. Note=Co-localizes with CDK5 in the cell body of neuronal cells. TISSUE SPECIFICITY: Predominantly expressed in brain; accumulates in cortical neurons (at protein level). PTM: O-glycosylated (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by CDK5. SIMILARITY: Belongs to the beta-catenin family. SIMILARITY: Contains 9 ARM repeats. SEQUENCE CAUTION: Sequence=AAB68599.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAB88185.1; Type=Frameshift; Positions=913; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ctnnd2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UQB3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
